Can Renal Sonography Be a Reliable Diagnostic Tool in the Assessment of Chronic Kidney Disease?

2015 ◽  
Vol 34 (2) ◽  
pp. 299-306 ◽  
Author(s):  
Gaetano Lucisano ◽  
Nicolino Comi ◽  
Elena Pelagi ◽  
Paola Cianfrone ◽  
Laura Fuiano ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Diagnostic Tool ◽  
Renal Sonography

Pilot study to evaluate the potential use of the renal resistive index as a preliminary diagnostic tool for chronic kidney disease in cats

2017 ◽  
Vol 20 (10) ◽  
pp. 940-947 ◽  
Author(s):  
Ines Matos ◽  
Pedro Azevedo ◽  
L Miguel Carreira
Keyword(s):  
Chronic Kidney Disease ◽  
Body Weight ◽  
Kidney Disease ◽  
Diagnostic Tool ◽  
Resistive Index ◽  
The Body ◽  
Receiver Operating Curve ◽  
Control Group ◽  
Preliminary Diagnosis ◽  
Potential Use

Objectives Chronic kidney disease (CKD) is the most common renal pathology diagnosed in geriatric cats, and its prevalence increases with age. The arterial resistive index (RI) is important when evaluating vascular resistance and compliance, and can be applied in the kidney (renal RI [RRI]), allowing the evaluation of its vascular haemodynamics. The present study aimed to: (1) investigate in cats with CKD the relationships between the RRI and the following parameters: age, sex, body weight, plasmatic creatinine, blood urea nitrogen, potassium, urine specific gravity, urine protein:creatinine ratio and systolic arterial pressure; and (2) evaluate the potential use of the RRI as a preliminary diagnostic tool in cats with CKD. Methods The present study involved 24 cats of both sexes. Six were healthy cats (control group [CG]) and 18 had CKD, but did not have any concomitant diseases and were not being treated with any medications (study group [SG]). For RRI measurement we used colour Doppler ultrasound (CDUS). Results RRI differed significantly between the CG and SG ( P <0.01) and was higher in the SG. A statistically significant correlation was only achieved between the RRI and the body weight of the patients and it was negative. A strong and positive correlation was noted between the mean RRI of both kidneys (r = 0.66). Receiver–operating curve analysis allowed us to establish an admissible cut-off for the RRI value of 0.639 for a preliminary diagnosis of CKD for both kidneys. Conclusions and relevance No differences were found for the RRI between the left and right kidneys, suggesting that evaluation of only one kidney is sufficient to provide an estimate of the RRI value for both organs. RRI measurement, which can be achieved with CDUS, is an easy-to-use diagnostic tool that, with a cut-off value of 0.639 for both kidneys, is useful in establishing a preliminary diagnosis of CKD.

scholarly journals Salivary creatinine as a diagnostic tool for evaluating patients with chronic kidney disease

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Dada Oluwaseyi Temilola ◽  
Karla Bezuidenhout ◽  
Rajiv Timothy Erasmus ◽  
Lawrence Stephen ◽  
Mogamat Razeen Davids ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Diagnostic Tool ◽  
Linear Regression Analysis ◽  
Strong Positive Correlation ◽  
Western Cape ◽  
Operating Characteristics ◽  
Creatinine Concentration ◽  
Cross Sectional ◽  
Non Invasive

Abstract Background Preliminary studies have shown the potential use of salivary creatinine concentration in the diagnosis of chronic kidney disease (CKD). For saliva to replace serum as a diagnostic tool, studies must be done to determine its effectiveness in the diagnosis and staging of CKD. The aim of the present study was to evaluate the use of salivary creatinine as a safe and non-invasive alternative for identifying patients with CKD. Methods A cross-sectional study was conducted at Tygerberg Hospital in Cape Town, on 230 patients, across all stages of CKD. Ethical approval to conduct the study was obtained from the University of the Western Cape Biomedical Research Ethics Committee, and written informed consent was provided by each participant. Saliva and serum samples were collected for creatinine analysis and the correlation determined using Spearman’s correlation. Receiver operating characteristics (ROC) analysis was used to determine the diagnostic ability of salivary creatinine. A cut-off value for optimal sensitivity and specificity of salivary creatinine to diagnose CKD with glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 was obtained. Results Serum creatinine values ranged from 46 μmol/L to 1581 μmol/L, with a median value of 134 μmol/L. Salivary creatinine values ranged from 3 μmol/L to 400 μmol/L, with a median of 11 μmol/L. There was a strong positive correlation (r = 0.82) between serum and salivary creatinine values. Linear regression analysis of serum and salivary creatinine for CKD patients was significant in all CKD stages, except for stage 1. Area under the curve for salivary creatinine was 0.839. A cut-off value of 8.5 μmol/L yielded a sensitivity of 78.3% and specificity of 74.0% for classifying patients as having CKD based on estimated GFR < 60 mL/min/1.73 m2. Conclusions The results support the potential of salivary creatinine as a non-invasive diagnostic tool for estimating GFR and identifying patients with CKD.

Case 7.22

2014 ◽  
pp. 347-348
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Chronic Kidney Disease ◽  
Bile Duct ◽  
Kidney Disease ◽  
Common Bile Duct ◽  
Renal Parenchyma ◽  
Growth Delay ◽  
Renal Sonography ◽  
The Common ◽  
T2 Weighted Images

8-year-old girl with chronic kidney disease, hypertension, and growth delay; a dilated common bile duct was noted incidentally at renal sonography Axial fat-suppressed FSE T2-weighted images (Figure 7.22.1) demonstrate replacement of much of the renal parenchyma with small, fairly uniform cysts. The common bile duct is dilated, the liver has a mildly cirrhotic appearance, and the spleen is markedly enlarged. Axial fat-suppressed SSFP images (...

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