scholarly journals Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease

Cureus ◽  
2020 ◽  
Author(s):  
Tony El Jabbour ◽  
Nicole Panarelli ◽  
Peter Muscarella ◽  
Garrison Pease
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Metastatic Disease ◽  
Lobular Carcinoma ◽  
Stromal Tumor ◽  
Calcifying Fibrous Pseudotumor

C-kit-positive gastric metastasis of lobular carcinoma of the breast masquerading as gastrointestinal stromal tumor

Breast Cancer ◽  
2009 ◽  
Vol 17 (4) ◽  
pp. 303-305 ◽  
Author(s):  
Bharathi Vennapusa ◽  
Sarah A. Oman ◽  
Gulshan Parasher ◽  
Lisa A. Cerilli
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Lobular Carcinoma ◽  
Stromal Tumor ◽  
Carcinoma Of The Breast ◽  
Gastric Metastasis

scholarly journals Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome

2018 ◽  
Vol 115 (25) ◽  
pp. E5746-E5755 ◽  
Author(s):  
Matthew L. Hemming ◽  
Matthew A. Lawlor ◽  
Rhamy Zeid ◽  
Tom Lesluyes ◽  
Jonathan A. Fletcher ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Gastrointestinal Stromal Tumor ◽  
Metastatic Disease ◽  
Tyrosine Kinases ◽  
Stromal Tumor ◽  
Primary Tumors ◽  
Transcription Factor Network ◽  
Activating Mutations ◽  
Kit Gene ◽  
Transcription Factor Expression

Activating mutations in the KIT or PDGFRA receptor tyrosine kinases are hallmarks of gastrointestinal stromal tumor (GIST). The biological underpinnings of recurrence following resection or disease progression beyond kinase mutation are poorly understood. Utilizing chromatin immunoprecipitation with sequencing of tumor samples and cell lines, we describe the enhancer landscape of GIST, highlighting genes that reinforce and extend our understanding of these neoplasms. A group of core transcription factors can be distinguished from others unique to localized and metastatic disease. The transcription factor HAND1 emerges in metastatic disease, binds to established GIST-associated enhancers, and facilitates GIST cell proliferation and KIT gene expression. The pattern of transcription factor expression in primary tumors is predictive of metastasis-free survival in GIST patients. These results provide insight into the enhancer landscape and transcription factor network underlying GIST, and define a unique strategy for predicting clinical behavior of this disease.

scholarly journals ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation:a case report

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Jun Fan ◽  
Ming Yang ◽  
Bo Huang ◽  
Zhenkao Wang ◽  
Danju Luo ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor
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