scholarly journals Ischemic Stroke in a Patient With Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes Syndrome Treated With Lenalidomide

Cureus ◽  
2020 ◽  
Author(s):  
Soujanya Sodavarapu ◽  
Arshian Mahajan
Keyword(s):  
Ischemic Stroke ◽  
Skin Changes ◽  
Monoclonal Protein

scholarly journals POEMS-syndrome: diagnostic difficulties

2020 ◽  
Vol 92 (7) ◽  
pp. 104-108
Author(s):  
P. A. Lebedev ◽  
E. V. Paranina ◽  
V. A. Rossiyev ◽  
E. Y. Fedorova ◽  
A. S. Nikolaeva
Keyword(s):  
Paraneoplastic Syndrome ◽  
Early Onset ◽  
Clinical Case ◽  
Specific Treatment ◽  
Poems Syndrome ◽  
Skin Changes ◽  
Monoclonal Protein ◽  
Diagnostic Difficulties

POEMS syndrome is a rare paraneoplastic syndrome whose name is an acronym formed from the initial letters of the names of the symptoms originally used to determine it: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes. Due to the rarity of the disease and the small number of cases described in the literature, its diagnosis is difficult. The average time from onset of symptoms to diagnosis is 18 months. Moreover, the prognosis of the disease depends on the early onset of specific treatment. The article describes a clinical case of POEMS-syndrome in a 53-year-old man, which illustrates the difficulties associated with the timely recognition of this unusual disease.

Polyneuropathy, organomegaly, endocrine manifestations, monoclonal protein, and skin changes, POEMS

2013 ◽  
pp. 74-76
Author(s):  
John H. J. Wokke ◽  
Pieter A. van Doorn ◽  
Jessica E. Hoogendijk ◽  
Marianne de Visser
Keyword(s):  
Skin Changes ◽  
Monoclonal Protein

scholarly journals Atypical polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes syndrome without polyneuropathy

Medicine ◽  
2020 ◽  
Vol 99 (27) ◽  
pp. e20812
Author(s):  
Qiang Li ◽  
Fang Xu ◽  
Jing-Feng Duan ◽  
Yu-Feng Tang
Keyword(s):  
Skin Changes ◽  
Monoclonal Protein

scholarly journals Ischemic stroke in patients with POEMS syndrome

2020 ◽  
Vol 4 (14) ◽  
pp. 3427-3434
Author(s):  
Jun Feng ◽  
Xue-min Gao ◽  
Hao Zhao ◽  
Tian-hua He ◽  
Cong-li Zhang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Plasma Cell ◽  
Underlying Mechanism ◽  
Poems Syndrome ◽  
College Hospital ◽  
Skin Changes ◽  
Medical College ◽  
Increased Risk ◽  
Plasma Cell Disorder ◽  
And Control

Abstract Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is associated with increased risk for ischemic stroke (IS). Because POEMS syndrome is rare, little is known regarding the underlying mechanism and prognosis for IS in patients in whom it occurs. The medical records of patients with POEMS syndrome were screened between January 2018 and January 2000 at Peking Union Medical College Hospital to identify those with IS. The baseline characteristics, IS features, and patient outcomes were analyzed. Forty-one (8.0%) of 510 POEMS patients were documented to have IS. Patients with IS were older, had a higher percentage of Overall Neuropathy Limitation Scale score >4, and had a higher level of fibrinogen compared with those who did not have IS. Ninety-three percent of IS events occurred before or within 3 months after a diagnosis of POEMS. Of 41 occurrences of IS, 29 (46.3%) were multifocal. Recurrent IS was observed in 13 (31.7%) of 41 patients, but not in patients with successful anti-plasma cell therapy. The 3-year overall survival rate in patients with IS was 71.0% and for those without IS, it was 88.5% (P = .002). We showed that 8.0% of POEMS patients had IS, and most IS events occurred in POEMS patients not being treated effectively. Having IS was a predictor of unfavorable prognosis. Early diagnosis, immediate initiation of treatment for POEMS, and control of POEMS syndrome is key to reducing the occurrence of IS, improving survival, and preventing recurrence of IS.

scholarly journals A relapse of POEMS syndrome presenting as acute kidney injury

2019 ◽  
Vol 12 (8) ◽  
pp. e228894
Author(s):  
David Owen Rees ◽  
David Hywel Thomas ◽  
Nilima Parry-Jones ◽  
Gareth Roberts
Keyword(s):  
Acute Kidney Injury ◽  
Peripheral Neuropathy ◽  
Rare Disease ◽  
Blood Test ◽  
Renal Involvement ◽  
Kidney Injury ◽  
Poems Syndrome ◽  
Skin Changes ◽  
Monoclonal Protein ◽  
History Of

Peripheral neuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes (POEMS) syndrome is a rare disease, and only in a minority of cases, causes an impairment of kidney function. Here, we describe a case of a 55-year-old man with a history of POEMS syndrome who presented with acute kidney injury following a routine blood test. On further investigation, a relapse in POEMS syndrome was diagnosed, uniquely isolated to renal involvement.

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