scholarly journals Morbilliform Rash: An Uncommon Herald of SARS-CoV-2

Cureus ◽  
2020 ◽  
Author(s):  
Radhika B Kulkarni ◽  
Yitzchok Lederman ◽  
Agura Afiari ◽  
Jacqueline A Savage ◽  
Jason Jacob
Keyword(s):  
Morbilliform Rash

scholarly journals Not your typical morbilliform rash: Angioimmunoblastic T‐cell lymphoma

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Wendi Bao ◽  
Kendall L. Buchanan ◽  
Loretta S. Davis
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Morbilliform Rash

scholarly journals Skin Manifestations Associated with COVID-19: Current Knowledge and Future Perspectives

Dermatology ◽  
2020 ◽  
pp. 1-12 ◽  
Author(s):  
Giovanni Genovese ◽  
Chiara Moltrasio ◽  
Emilio Berti ◽  
Angelo Valerio Marzano
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Features ◽  
Current Knowledge ◽  
Future Perspectives ◽  
Cutaneous Manifestations ◽  
Skin Manifestations ◽  
Global Pandemic ◽  
Morbilliform Rash ◽  
First Time ◽  
Polymorphic Nature

<b><i>Background:</i></b> Coronavirus disease-19 (COVID-19) is an ongoing global pandemic caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), which was isolated for the first time in Wuhan (China) in December 2019. Common symptoms include fever, cough, fatigue, dyspnea and hypogeusia/hyposmia. Among extrapulmonary signs associated with COVID-19, dermatological manifestations have been increasingly reported in the last few months. <b><i>Summary:</i></b> The polymorphic nature of COVID-19-associated cutaneous manifestations led our group to propose a classification, which distinguishes the following six main clinical patterns: (i) urticarial rash, (ii) confluent erythematous/maculopapular/morbilliform rash, (iii) papulovesicular exanthem, (iv) chilblain-like acral pattern, (v) livedo reticularis/racemosa-like pattern, (vi) purpuric “vasculitic” pattern. This review summarizes the current knowledge on COVID-19-associated cutaneous manifestations, focusing on clinical features and therapeutic management of each category and attempting to give an overview of the hypothesized pathophysiological mechanisms of these conditions.

scholarly journals Incidence of scrub typhus in a tertiary care hospital in Kolkata, India

2020 ◽  
Vol 7 (5) ◽  
pp. 825
Author(s):  
Kausik Munsi ◽  
Sayonee Das ◽  
Ramiz Islam ◽  
Parvez Shahide Biswas ◽  
Satyabrata Ganguly ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Tertiary Care ◽  
Febrile Illness ◽  
Signs And Symptoms ◽  
Care Hospital ◽  
Female Ratio ◽  
Gi Symptoms ◽  
Ns1 Antigen ◽  
Morbilliform Rash ◽  
Almost All

Background: Authors aimed to identify incidence of scrub typhus among patients of fever. Scrub typhus is an endemic disease in India caused by Orientia tsutsugamushi, transmitted by trombiculid mites. It is an important cause of acute febrile illness in India. Signs and symptoms include fever, headache, myalgia and GI symptoms and is generally associated with morbilliform rash (<40%), eschar (<50%) which is due to bite of the mite. Abnormal LFTs and lymphocytosis are commonly seen in early phase of illness. It’s often labelled as PUO. Early diagnosis and prompt administration of therapy mostly leads to complete recoveryMethods: Authors screened 100 patients presenting with fever, malaise, headache, with or without rash for more than a week from the month of May to December 2019. Routine blood investigations with fever profile (Dengue NS1 antigen, MP, MPDA, TyphidotM) and cultures were done. Patients in whom no cause of fever could be established, having lymphocytosis, hyponatremia and transaminitis, they were tested for Scrub typhus by using Indirect immunofluorescence & detection of IgM antibody.Results: Total 22 patients were found positive for scrub typhus by using the aforementioned method (22%). Male: Female ratio was 3:4 (9 vs 12). Patients were in the age group of 16-76 years. Lymphocytosis, hyponatremia and transaminitis were cardinal features seen in almost all patients diagnosed with Scrub Typhus.Conclusions: This study will help clinicians to have a stronger suspicion of scrub typhus in undiagnosed febrile patients.

scholarly journals Drug rash with eosinophilia and systemic symptoms syndrome, a uncommon but fatal illness, paediatricians should be aware of: a case of 13 year old female child

2020 ◽  
Vol 7 (3) ◽  
pp. 716
Author(s):  
Jyoti Ranjan Behera ◽  
Sanjay Kumar Sahu ◽  
Abhas Gupta
Keyword(s):  
Adolescent Girl ◽  
Female Child ◽  
Anti Psychotic ◽  
Dress Syndrome ◽  
Systemic Involvement ◽  
Drug Rash ◽  
Fatal Illness ◽  
Systemic Symptoms ◽  
Morbilliform Rash

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a fatal illness manifested by fever, morbilliform rash, multi systemic involvement and eosinophilic leucocytosis with about 10% mortality. Authors report DRESS syndrome in an adolescent girl due to anti-depressant and anti-psychotic which improved dramatically after withdrawal of offending drugs and starting of steroids

scholarly journals Rapidly progressive neurologic decline and morbilliform rash presenting in a patient with lymphoma

2018 ◽  
Vol 8 (4) ◽  
Author(s):  
Dean Ehrlich ◽  
Jennifer Phan ◽  
Gavin Hui ◽  
Alexandra Drakaki
Keyword(s):  
West Nile Virus ◽  
Lower Extremity ◽  
The United States ◽  
Immunoglobulin M ◽  
Initial Presentation ◽  
West Nile ◽  
Ongoing Research ◽  
Lower Extremity Weakness ◽  
Bilateral Lower Extremity ◽  
Morbilliform Rash

A 67-year-old male with past medical history of mantle cell lymphoma and atrial fibrillation presented with a truncal rash, bilateral lower extremity weakness, and confusion. Within three days of presentation, his condition rapidly deteriorated with the onset of diffuse flaccid paralysis, aphasia, and severe alteration in mental status. Initial results from serum studies, lumbar puncture, magnetic resonance imaging, and electroencephalogram were not diagnostic. However, on the ninth day after initial presentation, the West Nile Virus (WNV) immunoglobulin M antibody returned positive from the cerebrospinal fluid. West Nile Virus encephalitis is endemic worldwide, and is the most common viral encephalitis in the United States. WNV presents in a variety of ways, and the recognition by physicians is crucial due to the estimated 2- 12% mortality rate and significant longterm morbidity of neuroinvasive disease. The initial management and long term prognosis are points of ongoing research. This case represents a particularly profound example of neuroinvasive WNV. Our patient made a significant recovery after his initial presentation with aggressive supportive care, however still suffers from bilateral lower extremity weakness more than a year later.

scholarly journals Morbilliform rash

BMJ ◽  
2004 ◽  
Vol 329 (7468) ◽  
pp. 719.1 ◽  
Author(s):  
Caroline Furness ◽  
Rita Sharma ◽  
Anthony Harnden
Keyword(s):  
Morbilliform Rash

scholarly journals Clinical Features and Treatment Outcomes among Children with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A 20-Year Study in a Tertiary Referral Hospital

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Susheera Chatproedprai ◽  
Vanvara Wutticharoenwong ◽  
Therdpong Tempark ◽  
Siriwan Wananukul
Keyword(s):  
Supportive Care ◽  
Toxic Epidermal Necrolysis ◽  
Treatment Outcomes ◽  
Clinical Features ◽  
Systemic Therapy ◽  
Stevens Johnson Syndrome ◽  
Tertiary Referral Hospital ◽  
Systemic Corticosteroids ◽  
Johnson Syndrome ◽  
Morbilliform Rash

Aim. To determine the probable causative factors, clinical features, and treatment outcomes of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS-TEN overlap in children.Methods. A 20-year database review of all children diagnosed with SJS/TEN/SJS-TEN overlap at the King Chulalongkorn Memorial Hospital, Thailand.Results. 36 patients (M : F, 16 : 20) with the mean age of9.2±4.0years were identified. There were 20 cases of SJS, 4 cases of SJS-TEN overlap, and 12 cases of TEN. Drugs were the leading cause for the diseases (72.3%); antiepileptics were the most common culprits (36.1%). Cutaneous morphology at presentation was morbilliform rash (83.3%), blister (38.9%), targetoid lesions (25.0%), and purpuric macules (2.8%). Oral mucosa (97.2%) and eye (83.3%) were the 2 most common mucosal involvements. Majority of the cases (77.8%) were treated with systemic corticosteroids, intravenous immunoglobulin, or both. Treatment outcomes between those who received systemic therapy and those who received only supportive care were comparable. Skin and eye were the principal sites of short-term and long-term complications.Conclusions. SJS/TEN are not common but are serious diseases which lead to significant morbidities in children. Early withdrawal of suspicious causes and meticulous supportive care are very important. This study found that the systemic therapy was not superior to supportive care because the treatment outcomes for both groups were comparable.

scholarly journals A clinical study of cutaneous adverse drug reactions

2017 ◽  
Vol 6 (4) ◽  
pp. 919
Author(s):  
Riddhi Shah ◽  
Sakshi Agrawal ◽  
Neela Bhuptani
Keyword(s):  
Adverse Drug Reactions ◽  
Clinical Manifestations ◽  
Specific Treatment ◽  
Drug Reactions ◽  
Diagnostic Challenge ◽  
Female Ratio ◽  
Medical College ◽  
Causative Agents ◽  
Cutaneous Drug Reactions ◽  
Morbilliform Rash

Background: Adverse cutaneous drug reactions pose a diagnostic challenge due to a myriad of clinical manifestations and wide variety of causative agents. Present study aims to record various clinical patterns of adverse drug reactions, their causative agents and to study the pattern of morbidity and mortality in patients with severe cutaneous adverse drug reactions.Methods: 150 patients with adverse cutaneous drug reactions were included who came to Department of Dermatology, Venereology and Leprosy at PDU Govt. Medical College and Hospital, Rajkot, Gujarat from September 2009 to September 2011. Thorough history with all routine haematological and biochemical investigations, septic screening were done. HIV testing was done in severe reactions. Appropriate specific treatment was given with counselling regarding the offending drug.Results: The most common age group was 21-30 years (26.67%) with male to female ratio being 0.92:1. Morbilliform rash was the most common clinical type (42.67%) in both HIV reactive and non-reactive patients. Antimicrobials were the most common group (29.33%) and nevirapine was the most common offending drug (27.33%). Mortality rate was 2% (3 out of 150 cases) and all the patients were of toxic epidermal necrolysis.Conclusions: The pattern of cutaneous adverse drug reactions and the causative drugs are remarkably different in our study. Knowledge of the pattern and the causative agent helps in better management and reduced consequences in these patients particularly in severe adverse cutaneous drug reactions.

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