scholarly journals A Rare Case of Hemophagocytic Lymphohistiocytosis Associated with Parvovirus B19 Infection

Cureus ◽  
2016 ◽  
Author(s):  
Cai Yuan ◽  
FNU Asad-Ur-Rahman ◽  
Khalid Abusaada
2014 ◽  
Vol 124 ◽  
pp. 438-441 ◽  
Author(s):  
Michinori Mayama ◽  
Masato Yoshihara ◽  
Tetsuya Kokabu ◽  
Hidenori Oguchi

Cureus ◽  
2020 ◽  
Author(s):  
Neenu Kuruvilla ◽  
Vishnu Vinay ◽  
Rahul Rajendran ◽  
Irshad Ali KM ◽  
Sheela Kurian

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
C. J. Steffen ◽  
N. Koch ◽  
K. U. Eckardt ◽  
K. Amann ◽  
E. Seelow ◽  
...  

Abstract Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease characterized by hyperactivation of the immune system that causes hypercytokinemia and potentially multi organ failure. HLH can occur in patients with underlying rheumatic or autoinflammatory disorders. Additionally, HLH can develop in patients during infections or malignancies without a known genetic predisposition. Case presentation We herein report a patient, who presented with fever, both acute kidney and liver injury, anemia, thrombocytopenia and HSV stomatitis. HLH was diagnosed based on clinical criteria and qPCR revealed an acute parvovirus B19 infection as potential underlying infectious trigger. Treatment was started with both IVIG and dexamethasone. Subsequently, kidney biopsy demonstrated TMA. Conclusions In rare cases both HLH and aHUS can occur simultaneously in a patient as a consequence of viral infections. Insights from this unusual case might help physicians understand this complex symptom constellation.


2020 ◽  
Vol 13 (8) ◽  
pp. e234848
Author(s):  
Mazen Dajam ◽  
Yousef M Al Talhi ◽  
Jubara Alallah

We report a rare case of a preterm infant with a diagnosis of hydrops fetalis, associated with parvovirus B19 infection. At birth, the infant had severe ascites. She recovered and was discharged in later good condition. In follow-up at 10 years of age, she still had severe isolated hypoplasia of the abdominal muscles. Isolated hypoplasia of the abdominal muscles after parvovirus B19 infection appears to be a separate entity, which should be differentiated from other abdominal wall anomalies.


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