scholarly journals Systemic Review: Is an Intradiscal Injection of Platelet-Rich Plasma for Lumbar Disc Degeneration Effective?

Cureus ◽  
2020 ◽  
Author(s):  
Takashi Hirase ◽  
Robert A Jack II ◽  
Kyle R Sochacki ◽  
Joshua D Harris ◽  
Bradley K Weiner
Keyword(s):  
Disc Degeneration ◽  
Platelet Rich Plasma ◽  
Lumbar Disc ◽  
Systemic Review ◽  
Lumbar Disc Degeneration ◽  
Intradiscal Injection

scholarly journals Injection of platelet rich plasma for low backpain caused by lumbar disc degeneration: a prospective study

2020 ◽  
Vol 6 (5) ◽  
pp. 1032
Author(s):  
M. Shanmugam ◽  
Shivakumar .
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Disc Degeneration ◽  
Platelet Rich Plasma ◽  
Lumbar Disc ◽  
Functional Improvement ◽  
Low Back ◽  
Lumbar Disc Degeneration ◽  
Intradiscal Injection ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Though the etiologies of chronic low back pain can be diverse, lumbar disc degeneration is one of the important causes of low backpain. In intractable cases of low back pain surgical interventions may be warranted. Intradiscal injection of platelet rich plasma is emerging as a novel treatment modality for chronic backpain and has been reported to have good results in terms of reduction of pain and improvement in functional abilities.</p><p class="abstract"><strong>Methods:</strong> This was a prospective study in which 30 patients with chronic low back pain were included. Platelet rich plasma was injected in nucleus pulposus of the affected part of lumbar spine under fluoroscopic control. Patients were followed up for 3 months. Reduction in severity of pain and functional improvement was assessed by Visual Analogue Scores (VAS) and Roland-Morris Low Back Pain and Disability Questionnaire (RDQ) scores.<strong></strong></p><p class="abstract"><strong>Results:</strong> The Mean age of the male patients was found to be 50.05±9.04 while the mean age of females was found to be 48.50±10.19. 18 (60%) patients were either overweight or obese. Remaining 12 (40%) patients had a normal BMI. The difference between mean VAS scores and RDQ scores at presentation and 3 months after PRP injection was found to be statistically highly significant (p&lt;0.0001).</p><p class="abstract"><strong>Conclusions:</strong> The intradiscal injection of platelet rich plasma in patients with low back pain secondary to lumbar disc degeneration is effective in reducing back pain and causing significant functional improvement.</p>

Lumbar Disc Degeneration

1990 ◽  
Vol 31 (6) ◽  
pp. 551-554
Author(s):  
O. Tervonen ◽  
S. Lahde ◽  
J. Rydberg
Keyword(s):  
Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration

INTERVERTEBRAL DISC DEGENERATION LINKED TO STRUCTURAL GENE VARIATIONS

2019 ◽  
Author(s):  
Saeeda Baig
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
English Language ◽  
Tandem Repeats ◽  
Lumbar Disc ◽  
Disease Process ◽  
Nucleotide Polymorphisms ◽  
Structural Protein ◽  
Lumbar Disc Degeneration

During the recent past focus has shifted from identifying intervertebral disc degeneration as being caused by physical exposure and strain to being linked with a variety of genetic variations. The objective of this review is to provide an up to date review of the existing research data regarding the relation of intervertebral disc degeneration to structural protein genes and their polymorphisms and thus help clearly establish further avenues where research into causation and treatment is needed. A comprehensive search using the keywords “Collagen”, “COL”, “Aggrecan”, “AGC”, “IVDD”, “intervertebral disc degeneration”, and “lumbar disc degeneration” from PubMed and Google Scholar, where literature in the English language was selected spanning from 1991 to 2019. There are many genes involved in the production of structural components of an intervertebral disc. The issues in production of these components involve the over-expression or under-expression of their genes, and single nucleotide polymorphisms and variable number of tandem repeats affecting their structures. These structural genes include primarily the collagen and the aggrecan genes. While genetic and environmental factors all come into play with a disease process like disc degeneration, the bulk of research now shows the significantly larger impact of hereditary over exposure. While further research is needed into some of the lesser studied genes linked to IVDD and also the racial variations in genetic makeup, the focus in the near future should be on establishment of genetic testing to identify individuals at greater risk of disease and deliberation regarding the use of gene therapy to prevent disc degeneration.

Grading lumbar disc degeneration: a comparison between low- and high-field MRI

2019 ◽  
Vol 60 (12) ◽  
pp. 1636-1642 ◽  
Author(s):  
Bjarke B Hansen ◽  
Urszula M Ciochon ◽  
Charlotte R Trampedach ◽  
Anders F Christensen ◽  
Zoreh Rasti ◽  
...  
Keyword(s):  
Disc Degeneration ◽  
High Field ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
High Field Mri

Association between Measures of Vertebral Endplate Morphology and Lumbar Intervertebral Disc Degeneration

2017 ◽  
Vol 68 (2) ◽  
pp. 210-216 ◽  
Author(s):  
Semra Duran ◽  
Mehtap Cavusoglu ◽  
Hatice Gul Hatipoglu ◽  
Deniz Sozmen Cılız ◽  
Bulent Sakman
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Lumbar Disc ◽  
Lumbar Disc Degeneration ◽  
Vertebral Endplate ◽  
Lumbar Intervertebral Disc ◽  
Sagittal Diameter ◽  
Magnetic Resonance Imaging Mri ◽  
Vertebral Endplates

Purpose The aim of this study was to evaluate the association between vertebral endplate morphology and the degree of lumbar intervertebral disc degeneration via magnetic resonance imaging (MRI). Methods In total, 150 patients who met the inclusion criteria and were 20–60 years of age were retrospectively evaluated. Patients were evaluated for the presence of intervertebral disc degeneration or herniation, and the degree of degeneration was assessed at all lumbar levels. Vertebral endplate morphology was evaluated based on the endplate sagittal diameter, endplate sagittal concave angle (ECA), and endplate sagittal concave depth (ECD) on sagittal MRI. The association between intervertebral disc degeneration or herniation and endplate morphological measurements was analysed. Results In MRI, superior endplates ( ie, inferior endplates of the superior vertebra) were concave and inferior endplates ( ie, superior endplates of the inferior vertebra) were flat at all disc levels. A decrease in ECD and an increase in ECA were detected at all lumbar levels as disc degeneration increased ( P < .05). At the L4-L5 and L5-S1 levels, a decrease in ECD and an increase in ECA were detected in the group with herniated lumbar discs ( P < .05). There was no association between lumbar disc degeneration or herniation and endplate sagittal diameter at lumbar intervertebral levels ( P > .05). At all levels, ECD of women was significantly lesser than that of men and ECA of women was significantly greater than that of men ( P < .05). Conclusions There is an association between vertebral endplate morphology and lumbar intervertebral disc degeneration. Vertebral endplates at the degenerated disc level become flat; the severity of this flattening is correlated with the degree of disc degeneration.

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