scholarly journals Clinical Outcomes of Mechanical Prosthetic Valve Thrombosis

Cureus ◽  
2020 ◽  
Author(s):  
Hamid Sharif Khan ◽  
Zainab Ijaz ◽  
Muhammad Ali ◽  
Mohsin Saif ◽  
Uzma Ishaq ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Prosthetic Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve

Fast versus ultra-slow thrombolytic infusion regimens in patients with obstructive mechanical prosthetic valve thrombosis: a pilot randomized clinical trial

2021 ◽  
Author(s):  
Parham Sadeghipour ◽  
Sedigheh Saedi ◽  
Leila Saneei ◽  
Farnaz Rafiee ◽  
Siamak Yoosefi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Prosthetic Valve ◽  
Randomized Clinical Trials ◽  
Absolute Risk ◽  
Tissue Type ◽  
Symptom Improvement ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve

Abstract Background Thrombolysis is an alternative to surgery for mechanical prosthetic valve thrombosis (MPVT). Randomized clinical trials have yet to test safety and efficacy of a proposed ultraslow thrombolytic infusion regimen. Methods and Results This single-center, open-label, pilot randomized clinical trial randomized adult patients with acute obstructive MPVT to an ultraslow thrombolytic regimen (25 mg of recombinant tissue-type plasminogen activator [rtPA] infused in 25h) and a fast thrombolytic regimen (50 mg of rtPA infused in 6h). If thrombolysis failed, a repeated dose of 25 mg of rtPA for 6h was administered in both groups up to a cumulative dose of 150 mg or the occurrence of a complication. Primary outcome was a complete MPVT resolution (>75% fall in the obstructive gradient by transthoracic echocardiography, <10° limitation in opening and closing valve motion angles by fluoroscopy, and symptom improvement). Key safety outcome was a BARC type III or V major bleeding. Overall, 120 patients, including 63 (52.5%) women, at a mean age of 36.3±15.3 years, were randomized. Complete thrombolysis success was achieved in 51 patients (85.0%) in the ultraslow-regimen group and 47 patients (78.3%) in the fast-regimen group (OR, 1.58; 95% CI, 0.25 to 1.63; P = 0.34). One case of transient ischemic attack and 3 cases of intracranial hemorrhage (absolute risk difference, −12.5%; 95% CI, −23.1% to −1.0%; P = 0.04). were observed only in the fast-regimen group. Conclusions The ultraslow thrombolytic regimen conferred a high thrombosis resolution rate without major complications. Such findings should be replicated in more adequately powered trials (IRCT20181022041406N2).

Massive On-X mitral mechanical prosthetic valve thrombosis in NYHA class I patient

2016 ◽  
pp. 1025-1025
Author(s):  
María Elena Arnáiz-García ◽  
José María González-Santos ◽  
Javier López-Rodríguez ◽  
Alberto Iscar-Galán ◽  
María José Dalmau-Sorlí ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Nyha Class ◽  
Class I ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve

scholarly journals MITRAL MECHANICAL PROSTHETIC VALVE THROMBOSIS FOUR YEARS AFTER DISCONTINUING ANTICOAGULATION: A CASE REPORT

2015 ◽  
Vol 4 (29) ◽  
pp. 5068-5072
Author(s):  
Ravi Venkatachelam Chitrapu ◽  
Srinivasa Rao D ◽  
Saheb Peer D ◽  
Ram Pakkira O ◽  
Subrahmanya Sarma P V R S
Keyword(s):  
Case Report ◽  
Prosthetic Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve

P2-7 FIBRINOLYTIC THRAPY FOR MECHANICAL PROSTHETIC VALVE THROMBOSIS

2007 ◽  
Vol 122 ◽  
pp. S83
Author(s):  
S.H. Hakim ◽  
J. Samadikhah ◽  
S. Gaffari ◽  
A. Alizadeh ◽  
R. Azarfarin
Keyword(s):  
Prosthetic Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve

scholarly journals Mechanical prosthetic valve thrombosis in current era: 5-year follow-up

2020 ◽  
Author(s):  
Supaksh Mahindru ◽  
Shantanu Pande ◽  
Pulkit Malhotra ◽  
Ankit Thukral ◽  
Ankush Singh Kotwal ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve

Nonobstructive mechanical prosthetic valve thrombosis with acute stroke

2013 ◽  
Vol 21 (2) ◽  
pp. 196-198
Author(s):  
Prashanth Panduranga ◽  
Taha Al-Delamie ◽  
Mohammed Al-Mukhaini
Keyword(s):  
Acute Stroke ◽  
Prosthetic Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve

scholarly journals P4517Long-term treatment in survivors after an acute prosthetic valve thrombosis: is it possible to improve clinical outcomes?

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
R Fernandez-Galera ◽  
J F Rodriguez-Palomares ◽  
L Gutierrez Garcia-Moreno ◽  
L Galian Gay ◽  
G Teixido Tura ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Prosthetic Valve ◽  
Term Treatment ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis

scholarly journals Fibrinolysis of mechanical prosthetic valve thrombosis

2003 ◽  
Vol 41 (4) ◽  
pp. 653-658 ◽  
Author(s):  
Raymond Roudaut ◽  
S.téphane Lafitte ◽  
Marie-Françoise Roudaut ◽  
Carine Courtault ◽  
Jean-Marie Perron ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis ◽  
Mechanical Prosthetic Valve
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