scholarly journals Drug-Induced Immune Thrombocytopenia From Administration of a Local Anesthetic Agent Resulting in Splenectomy

Cureus ◽  
2020 ◽  
Author(s):  
Safwan Muhammad ◽  
Ammad Naeem ◽  
Amna Shaukat ◽  
Subas Javaid ◽  
Saqib Alvi
Keyword(s):  
Local Anesthetic ◽  
Immune Thrombocytopenia ◽  
Anesthetic Agent ◽  
Drug Induced ◽  
Local Anesthetic Agent

Rhabdomyolysis following Accidental Intra-arterial Injection of Local Anesthetic

Angiology ◽  
2008 ◽  
Vol 60 (1) ◽  
pp. 120-121 ◽  
Author(s):  
Ozer Selimoglu ◽  
Murat Basaran ◽  
Murat Ugurlucan ◽  
Temucin Noyan Ogus
Keyword(s):  
Coronary Angiography ◽  
Femoral Artery ◽  
Local Anesthetic ◽  
Intramuscular Injection ◽  
Anesthetic Agent ◽  
Drug Induced ◽  
Local Anesthetic Agent ◽  
Nicolau Syndrome

Drug-induced myopathy, also named Nicolau syndrome, is a well-known phenomenon following intramuscular injection of certain agents, most commonly reported with penicillin or diclofenac. The mechanism responsible for the pathology is proposed to be incidental administration of the drug into the small arterioles. In this report, we present a Nicolau syndrome-like case that developed following accidental injection of a local anesthetic agent into the femoral artery during coronary angiography.

Amitriptyline Neurotoxicity

2004 ◽  
Vol 100 (6) ◽  
pp. 1519-1525 ◽  
Author(s):  
Jean-Pierre Estebe ◽  
Robert R. Myers
Keyword(s):  
Nervous System ◽  
Sciatic Nerve ◽  
Local Anesthetic ◽  
Dose Range ◽  
Antidepressant Drug ◽  
Nerve Fibers ◽  
Anesthetic Agent ◽  
Sprague Dawley ◽  
Neurotoxic Effect ◽  
Local Anesthetic Agent

Background Amitriptyline is a tricyclic antidepressant drug used systemically for the management of neuropathic pain. Antidepressants, as a class of drugs with direct neurologic actions, are becoming widely used for the management of chronic pain, although their mechanisms are not entirely understood. Amitriptyline exerts potent effects on reuptake of norepinephrine and serotonin and blocks alpha 2A adrenoreceptors and N-methyl-D-aspartate receptors. Because amitriptyline is also a particularly potent blocker of sodium channels and voltage-gated potassium and calcium channels, it has been recommended as a long-acting local anesthetic agent. Unfortunately, amitriptyline has significant toxic side effects in the central nervous system and cardiovascular system that are dose-related to its systemic administration. Therefore, before amitriptyline can be used clinically as a local anesthetic agent, it should be thoroughly explored with respect to its direct neurotoxic effect in the peripheral nervous system. Methods The left sciatic nerve of Sprague-Dawley rats (12/ group) received a single topical amitriptyline dose of 0.625, 1.25, 2.5, or 5 mg; a saline group (n = 2) was used as control. Neuropathologic evaluations were conducted in separate animals (n = 4) 1, 3, and 7 days later. Results Amitriptyline topically applied in vivo to rat sciatic nerve causes a dose-related neurotoxic effect. Drug doses of 0.625-5 mg all caused Wallerian degeneration of peripheral nerve fibers, with the number of affected fibers and the severity of the injury directly related to the dose. Conclusion Because the effective local anesthetic dose is within this dose range, the authors strongly recommend that amitriptyline not be used as a local anesthetic agent.

DYCLONINE—A NEW LOCAL ANESTHETIC AGENT

1956 ◽  
Vol 17 (5) ◽  
pp. 648-652 ◽  
Author(s):  
Leroy C. Harris ◽  
John C. Parry ◽  
F. E. Greifenstein
Keyword(s):  
Local Anesthetic ◽  
Anesthetic Agent ◽  
Local Anesthetic Agent

Subdural Spread of Local Anesthetic Agent following Thoracic Paravertebral Block and Cannulation

2003 ◽  
Vol 98 (4) ◽  
pp. 1005-1007 ◽  
Author(s):  
Ignacio Garutti ◽  
Monica Hervias ◽  
Jose Maria Barrio ◽  
Fernando Fortea ◽  
Jesus de la Torre
Keyword(s):  
Local Anesthetic ◽  
Paravertebral Block ◽  
Anesthetic Agent ◽  
Thoracic Paravertebral Block ◽  
Local Anesthetic Agent

ETIDOCAINE-A NEW LONG-ACTING LOCAL ANESTHETIC AGENT

1974 ◽  
Vol 18 (2) ◽  
pp. 182
Author(s):  
P. C. LUND ◽  
J. C. CWIK ◽  
R. T. PAGDANGANAN
Keyword(s):  
Local Anesthetic ◽  
Anesthetic Agent ◽  
Local Anesthetic Agent ◽  
Long Acting
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