scholarly journals Cryosurgery Versus Primary Androgen Deprivation Therapy for Locally Recurrent Prostate Cancer After Primary Radiotherapy: A Propensity-Matched Survival Analysis

Cureus ◽  
2020 ◽  
Author(s):  
Glenn Bauman ◽  
Keyue Ding ◽  
Joseph Chin ◽  
Shiva Nair ◽  
Alessandra Iaboni ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Survival Analysis ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Recurrent Prostate Cancer ◽  
Primary Androgen Deprivation Therapy ◽  
Primary Radiotherapy ◽  
Locally Recurrent ◽  
Primary Androgen Deprivation

scholarly journals Is Primary Androgen Deprivation Therapy a Suitable Option for Asian Patients With Prostate Cancer Compared With Radical Prostatectomy?

2019 ◽  
Vol 17 (5) ◽  
pp. 441-449 ◽  
Author(s):  
U-Syn Ha ◽  
Jin Bong Choi ◽  
Jung Im Shim ◽  
Minjoo Kang ◽  
Eunjung Park ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Survival Analysis ◽  
Radical Prostatectomy ◽  
Androgen Deprivation Therapy ◽  
Locally Advanced ◽  
Androgen Deprivation ◽  
Primary Androgen Deprivation Therapy ◽  
Risk Of Death ◽  
Increased Risk ◽  
Primary Androgen Deprivation

Background: We conducted a comparative survival analysis between primary androgen deprivation therapy (PADT) and radical prostatectomy (RP) based on nationwide Korean population data that included all patients with prostate cancer. Materials and Methods: This study enrolled 4,538 patients with prostate cancer from the National Health Insurance Service (NHIS) database linked with Korean Central Cancer Registry data who were treated with PADT or RP between January 1, 2007, and December 31, 2014. Kaplan-Meier and multivariate survival analyses stratified by stage (localized and locally advanced) and age (<75 and ≥75 years) were performed using a Cox proportional hazards model to evaluate treatment effects. Results: Among 18,403 patients from the NHIS database diagnosed with prostate cancer during the study period, 4,538 satisfied inclusion criteria and were included in the analyses. Of these, 3,136 and 1,402 patients underwent RP or received PADT, respectively. Risk of death was significantly increased for patients who received PADT compared with those who underwent RP in the propensity score–matched cohort. In subgroup analyses stratified by stage and age, in every subgroup, patients who received PADT had a significantly increased risk of death compared with those who underwent RP. In particular, a much greater risk was observed for patients with locally advanced prostate cancer. Conclusions: Based on a nationwide survival analysis of nonmetastatic prostate cancer, this study provides valuable clinical implications that favor RP over PDAT for treatment of Asian populations. However, the possibility that survival differences have been overestimated due to not accounting for potential confounding characteristics must be considered.

Associations between statin use and progression in men with prostate cancer treated with primary androgen deprivation therapy

2017 ◽  
Vol 51 (6) ◽  
pp. 464-469 ◽  
Author(s):  
Marta Kramer Mikkelsen ◽  
Frederik Birkebæk Thomsen ◽  
Kasper Drimer Berg ◽  
Mary Jarden ◽  
Signe Benzon Larsen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Primary Androgen Deprivation Therapy ◽  
Statin Use ◽  
Primary Androgen Deprivation

scholarly journals Trans-Pacific variation in outcomes for men treated with primary androgen-deprivation therapy (ADT) for prostate cancer

2015 ◽  
Vol 117 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Matthew R. Cooperberg ◽  
Shiro Hinotsu ◽  
Mikio Namiki ◽  
Peter R. Carroll ◽  
Hideyuki Akaza
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Primary Androgen Deprivation Therapy ◽  
Primary Androgen Deprivation
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