scholarly journals Post-Traumatic, Drug-Resistant Epilepsy and Review of Seizure Control Outcomes from Blinded, Randomized Controlled Trials of Brain Stimulation Treatments for Drug-Resistant Epilepsy

Cureus ◽  
2016 ◽  
Author(s):  
Michael Larkin ◽  
R. Michael Meyer ◽  
Nicholas S Szuflita ◽  
Meryl A Severson ◽  
Zachary T Levine
Keyword(s):  
Randomized Controlled Trials ◽  
Brain Stimulation ◽  
Seizure Control ◽  
Controlled Trials ◽  
Drug Resistant ◽  
Randomized Controlled ◽  
Post Traumatic ◽  
Drug Resistant Epilepsy

Interventions to Reduce Alcohol Harms in Low and Middle Income Countries: a Systematic Review and Meta Analysis

2018 ◽  
Author(s):  
Joao Ricardo Nickenig Vissoci
Keyword(s):  
Systematic Review ◽  
Alcohol Use ◽  
Randomized Controlled Trials ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
World Health ◽  
Controlled Trials ◽  
Middle Income ◽  
Brief Motivational Intervention ◽  
Randomized Controlled

BackgroundHarmful alcohol use leads to a large burden of disease and disability which disportionately impacts LMICs. The World Health Organization and the Lancet have issued calls for this burden to be addressed, but issues remain, primarily due to gaps in information. While a variety of interventions have been shown to be effective at reducing alcohol use in HICs, their efficacy in LMICs have yet to be assessed. This systematic review describes the current published literature on alcohol interventions in LMICs and conducts a meta analysis of clinical trials evaluating interventions to reduce alcohol use and harms in LMICs.MethodsIn accordance with PRISMA guidelines we searched the electronic databases Pubmed, EMBASE, Scopus,Web of Science, Cochrane, and Psych Info. Articles were eligible if they evaluated an intervention targeting alcohol-related harm in LMICs. After a reference and citation analysis, we conducted a quality assessment per PRISMA protocol. A meta-analysis was performed on the 39 randomized controlled trials that evaluated an alcohol-related outcome.ResultsOf the 3,801 articles from the literature search, 87 articles from 25 LMICs fit the eligibility and inclusion criteria. Of these studies, 39 randomized controlled trials were included in the meta-analysis. Nine of these studies focused specifically on medication, while the others focused on brief motivational intervention, brain stimulation, AUDIT-based brief interventions, WHO ASSIST-based interventions, group based education, basic screening and interventions, brief psychological or counseling, dyadic relapse prevention, group counseling, CBT, motivational + PTSD based interview, and health promotion/awareness. Conclusion Issues in determining feasible options specific to LMICs arise from unstandardized interventions, unequal geographic distribution of intervention implementation, and uncertain effectiveness over time. Current research shows that brain stimulation, psychotherapy, and brief motivational interviews have the potential to be effective in LMIC settings, but further feasibility testing and efforts to standardize results are necessary to accurately assess their effectiveness.

Characterization of the adverse events profile of placebo-treated patients in randomized controlled trials on drug-resistant focal epilepsies

2014 ◽  
Vol 262 (6) ◽  
pp. 1401-1406 ◽  
Author(s):  
Fabio Giovannelli ◽  
Gaetano Zaccara ◽  
Massimo Cincotta ◽  
Giulia Loiacono ◽  
Alberto Verrotti
Keyword(s):  
Adverse Events ◽  
Randomized Controlled Trials ◽  
Controlled Trials ◽  
Drug Resistant ◽  
Randomized Controlled

scholarly journals Deep brain stimulation for seizure control in drug-resistant epilepsy

2018 ◽  
Vol 45 (2) ◽  
pp. E4 ◽  
Author(s):  
Neil Klinger ◽  
Sandeep Mittal
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Seizure Control ◽  
Effective Means ◽  
Drug Resistant ◽  
Thalamic Nuclei ◽  
Stimulation Parameters ◽  
Number Of Patients ◽  
Drug Resistant Epilepsy ◽  
Deep Brain

Antiepileptic drugs prevent morbidity and death in a large number of patients suffering from epilepsy. However, it is estimated that approximately 30% of epileptic patients will not have adequate seizure control with medication alone. Resection of epileptogenic cortex may be indicated in medically refractory cases with a discrete seizure focus in noneloquent cortex. For patients in whom resection is not an option, deep brain stimulation (DBS) may be an effective means of seizure control. Deep brain stimulation targets for treating seizures primarily include the thalamic nuclei, hippocampus, subthalamic nucleus, and cerebellum. A variety of stimulation parameters have been studied, and more recent advances in electrical stimulation to treat epilepsy include responsive neurostimulation. Data suggest that DBS is effective for treating drug-resistant epilepsy.

Deep brain stimulation in Parkinson’s disease: meta-analysis of randomized controlled trials

2014 ◽  
Vol 261 (11) ◽  
pp. 2051-2060 ◽  
Author(s):  
L. Perestelo-Pérez ◽  
A. Rivero-Santana ◽  
J. Pérez-Ramos ◽  
P. Serrano-Pérez ◽  
J. Panetta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Randomized Controlled Trials ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Deep Brain

Adverse events of placebo-treated, drug-resistant, focal epileptic patients in randomized controlled trials: a systematic review

2014 ◽  
Vol 262 (3) ◽  
pp. 501-515 ◽  
Author(s):  
Gaetano Zaccara ◽  
Fabio Giovannelli ◽  
Massimo Cincotta ◽  
Giulia Loiacono ◽  
Alberto Verrotti
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Randomized Controlled Trials ◽  
Controlled Trials ◽  
Drug Resistant ◽  
Randomized Controlled ◽  
Epileptic Patients

scholarly journals Percutaneous epidural adhesiolysis – treatment method for drug-resistant back pain

2021 ◽  
Author(s):  
Andrzej Zawadzki ◽  
Marta Zawadzka ◽  
Mateusz Maciej Węclewicz ◽  
Wojciech Skrobot ◽  
Wojciech Kloc
Keyword(s):  
Back Pain ◽  
Randomized Controlled Trials ◽  
Treatment Method ◽  
Controlled Trials ◽  
Drug Resistant ◽  
Randomized Controlled ◽  
Canal Stenosis ◽  
Anesthetic Drugs ◽  
Post Surgery ◽  
Experienced Physician

Introduction: Percutaneous epidural adhesiolysis (epidural decompressive neuroplasty, percutaneous epidural neuroplasty) is treatment method for drug-resistant back pain, including post-surgery syndrome, sciatica or spinal canal stenosis. Aim: To describe the method and outcomes of epidural adhesiolysis. Material and methods: The review of the literature on the topic of epidural adhesiolysis. Results and discussion: This procedure is usually performed in the lumbo-sacral part of the spine, although it can be also done in the cervical or thoracic parts as well. Its purpose is to administer anesthetic drugs, steroids, saline solution or hyaluronidase into the epidural space via one of the three approaches: caudal, interlaminar and transforaminal. The efficacy of epidural adhesiolysis was proven in numerous randomized controlled trials. Conclusions: The efficacy of epidural adhesiolysis was proven in numerous randomized controlled trials. When performed by an experienced physician, epidural adhesiolysis is a safe and effective method with infrequent adverse events.

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