scholarly journals Chemical Colitis Induced by Low-dose Hydrogen Peroxide Enema in a Cocaine User

Cureus ◽  
2020 ◽  
Author(s):  
Jason Galo ◽  
Michelle Zaydlin ◽  
Diego A Celli-Cabada
Keyword(s):  
Hydrogen Peroxide ◽  
Low Dose ◽  
Cocaine User ◽  
Chemical Colitis

scholarly journals Cromoglycate and nedocromil enhanced the reactive oxygen species-dependent suppressions with, but not without, dexamethasone in ischaemic and histamine paw oedema of mice

1997 ◽  
Vol 6 (5-6) ◽  
pp. 369-374
Author(s):  
Y. Oyanagui
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Superoxide Dismutase ◽  
Glucocorticoid Receptor ◽  
Low Dose ◽  
Natural Antioxidant ◽  
Target Cells ◽  
Oxygen Species ◽  
Paw Oedema ◽  
Β Carotene

Anti-inflammatory actions of two anti-allergic drugs, alone or with dexamethasone (Dex) were examined in two models, because inflammation is claimed to be important for allergic events, especially for asthma. Cromoglycate and nedocromil were tested in ischaemic- and histamineinduced paw oedema models of mice. These antiallergic drugs (1–100 mg/kg, i.p.) failed to suppress these oedemata, but enhanced the suppressions by a low dose of dexamethasone (0.1 mg/kg, s.c.) at 3–8 h after Dex injection. The mode of effects by anti-allergic drugs resembled that of a natural antioxidant (α-tocopherol, β-carotene etc.), and was different from that of an immunosuppressant like FK506. The enhancing potencies of the two anti-allergic drugs were similar at 6 h after Dex in both oedemata, and were diminished by superoxide dismutase (SOD) or catalase (i.p.). Cycloheximide completely abolished suppressions. Nedocromil, but not cromoglycate, inhibits inflammatory events. Therefore, there are common unknown actions by which the two anti-allergics enhance suppression by Dex. A possible mechanism of this action was supposed to enhance the superoxide and/or hydrogen peroxide-dependent glucocorticoid receptor (GR) signalling in the target cells.

scholarly journals A Case of Chemical Colitis Caused by Hydrogen Peroxide Enema

2011 ◽  
Vol 58 (2) ◽  
pp. 100 ◽  
Author(s):  
Chul Hyun Lim ◽  
Hwa Young Lee ◽  
Won Chul Kim ◽  
Soung Hoon Cho ◽  
Hee Sun Jeong ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Chemical Colitis

scholarly journals Identification of Two Kinase Inhibitors with Synergistic Toxicity with Low-Dose Hydrogen Peroxide in Colorectal Cancer Cells In vitro

Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 122 ◽  
Author(s):  
Eric Freund ◽  
Kim-Rouven Liedtke ◽  
Lea Miebach ◽  
Kristian Wende ◽  
Amanda Heidecke ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Hydrogen Peroxide ◽  
Protein Kinase ◽  
Tumor Cells ◽  
Low Dose ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Colorectal Cancer Cells

Colorectal carcinoma is among the most common types of cancers. With this disease, diffuse scattering in the abdominal area (peritoneal carcinosis) often occurs before diagnosis, making surgical removal of the entire malignant tissue impossible due to a large number of tumor nodules. Previous treatment options include radiation and its combination with intraperitoneal heat-induced chemotherapy (HIPEC). Both options have strong side effects and are often poor in therapeutic efficacy. Tumor cells often grow and proliferate dysregulated, with enzymes of the protein kinase family often playing a crucial role. The present study investigated whether a combination of protein kinase inhibitors and low-dose induction of oxidative stress (using hydrogen peroxide, H2O2) has an additive cytotoxic effect on murine, colorectal tumor cells (CT26). Protein kinase inhibitors from a library of 80 substances were used to investigate colorectal cancer cells for their activity, morphology, and immunogenicity (immunogenic cancer cell death, ICD) upon mono or combination. Toxic compounds identified in 2D cultures were confirmed in 3D cultures, and additive cytotoxicity was identified for the substances lavendustin A, GF109203X, and rapamycin. Toxicity was concomitant with cell cycle arrest, but except HMGB1, no increased expression of immunogenic markers was identified with the combination treatment. The results were validated for GF109203X and rapamycin but not lavendustin A in the 3D model of different colorectal (HT29, SW480) and pancreatic cancer cell lines (MiaPaca, Panc01). In conclusion, our in vitro data suggest that combining oxidative stress with chemotherapy would be conceivable to enhance antitumor efficacy in HIPEC.

scholarly journals Removal of Positively Buoyant Planktothrix rubescens in Lake Restoration

Toxins ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 700 ◽  
Author(s):  
Miquel Lürling ◽  
Maíra Mucci ◽  
Guido Waajen
Keyword(s):  
Hydrogen Peroxide ◽  
The Netherlands ◽  
Chlorophyll A ◽  
Lake Restoration ◽  
Low Dose ◽  
Cyanobacterial Blooms ◽  
Similar Species ◽  
Modified Bentonite ◽  
Planktothrix Rubescens ◽  
Polyaluminium Chloride

The combination of a low-dose coagulant (polyaluminium chloride—‘Floc’) and a ballast able to bind phosphate (lanthanum modified bentonite, LMB—‘Sink/Lock’) have been used successfully to manage cyanobacterial blooms and eutrophication. In a recent ‘Floc and Lock’ intervention in Lake de Kuil (the Netherlands), cyanobacterial chlorophyll-a was reduced by 90% but, surprisingly, after one week elevated cyanobacterial concentrations were observed again that faded away during following weeks. Hence, to better understand why and how to avoid an increase in cyanobacterial concentration, experiments with collected cyanobacteria from Lakes De Kuil and Rauwbraken were performed. We showed that the Planktothrix rubescens from Lake de Kuil could initially be precipitated using a coagulant and ballast but, after one day, most of the filaments resurfaced again, even using a higher ballast dose. By contrast, the P. rubescens from Lake Rauwbraken remained precipitated after the Floc and Sink/Lock treatment. We highlight the need to test selected measures for each lake as the same technique with similar species (P. rubescens) yielded different results. Moreover, we show that damaging the cells first with hydrogen peroxide before adding the coagulant and ballast (a ‘Kill, Floc and Lock/Sink’ approach) could be promising to keep P. rubescens precipitated.

Short-term pretreatment with low-dose hydrogen peroxide enhances the efficacy of bone marrow cells for therapeutic angiogenesis

2007 ◽  
Vol 292 (6) ◽  
pp. H2582-H2588 ◽  
Author(s):  
Masayuki Kubo ◽  
Tao-Sheng Li ◽  
Ryo Suzuki ◽  
Mako Ohshima ◽  
Shu-Lan Qin ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Bone Marrow ◽  
Low Dose ◽  
Bone Marrow Cells ◽  
Therapeutic Angiogenesis ◽  
Pcr Analysis ◽  
Endothelial Differentiation ◽  
Short Term ◽  
Marrow Cells

Therapeutic angiogenesis can be induced by the implantation of bone marrow cells (BMCs). Hydrogen peroxide (H2O2) has been shown to increase VEGF expression and to be involved in angiogenesis. We tested the hypothesis that pretreatment with H2O2 enhances the efficacy of BMCs for neovascularization. H2O2 pretreatment was done by incubating mouse BMCs in 5 μM H2O2 for 30 min, followed by washing twice with PBS. The H2O2-pretreated and untreated BMCs were then studied in vitro and in vivo. RT-PCR analysis showed that expression of VEGF and Flk-1 mRNA was significantly higher in H2O2-pretreated BMCs than in untreated BMCs after 12 and 24 h of culture ( P < 0.01). Pretreatment with H2O2 also effectively enhanced the VEGF production and endothelial differentiation from BMCs after 1 and 7 days of culture ( P < 0.05). To estimate the angiogenic potency in vivo, H2O2-pretreated or untreated BMCs were intramuscularly implanted into the ischemic hindlimbs of mice. After 14 days of treatment, many of the H2O2-pretreated BMCs were viable, showed endothelial differentiation, and were incorporated in microvessels. Conversely, the survival and incorporation of the untreated BMCs were relatively poor. Microvessel density and blood flow in the ischemic hindlimbs were significantly greater in the mice implanted with H2O2-pretreated BMCs than in those implanted with untreated BMCs ( P < 0.05). These results show that the short-term pretreatment of BMCs with low-dose H2O2 is a novel, simple, and feasible method of enhancing their angiogenic potency.

Severe Chemical Colitis Due to Hydrogen Peroxide Enema

2011 ◽  
Vol 106 ◽  
pp. S316
Author(s):  
Bryan Love ◽  
Saima Siddiqui ◽  
Richard Helman ◽  
Brown McCallum
Keyword(s):  
Hydrogen Peroxide ◽  
Chemical Colitis
Sign in / Sign up

Export Citation Format

Share Document