scholarly journals The Neuroprotective Effects of Exercise on Cognitive Decline: A Preventive Approach to Alzheimer Disease

Cureus ◽  
2020 ◽  
Author(s):  
Muhammad Humayoun Rashid ◽  
Muhammad Farhan Zahid ◽  
Sarmad Zain ◽  
Ahmad Kabir ◽  
Sibt Ul Hassan
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Neuroprotective Effects ◽  
Preventive Approach

scholarly journals The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease

2015 ◽  
Vol 95 (7) ◽  
pp. 1046-1060 ◽  
Author(s):  
Cristy Phillips ◽  
Mehmet Akif Baktir ◽  
Devsmita Das ◽  
Bill Lin ◽  
Ahmad Salehi
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Cognitive Dysfunction ◽  
Physical Therapist ◽  
Disease Process ◽  
Sufficient Evidence ◽  
Brain Disorder ◽  
Neuroprotective Effects

Alzheimer disease (AD) is a primary cause of cognitive dysfunction in the elderly population worldwide. Despite the allocation of enormous amounts of funding and resources to studying this brain disorder, there are no effective pharmacological treatments for reducing the severity of pathology and restoring cognitive function in affected people. Recent reports on the failure of multiple clinical trials for AD have highlighted the need to diversify further the search for new therapeutic strategies for cognitive dysfunction. Thus, studies detailing the neuroprotective effects of physical activity (PA) on the brain in AD were reviewed, and mechanisms by which PA might mitigate AD-related cognitive decline were explored. A MEDLINE database search was used to generate a list of studies conducted between January 2007 and September 2014 (n=394). These studies, along with key references, were screened to identify those that assessed the effects of PA on AD-related biomarkers and cognitive function. The search was not limited on the basis of intensity, frequency, duration, or mode of activity. However, studies in which PA was combined with another intervention (eg, diet, pharmacotherapeutics, ovariectomy, cognitive training, behavioral therapy), and studies not written in English were excluded. Thirty-eight animal and human studies met entry criteria. Most of the studies suggested that PA attenuates neuropathology and positively affects cognitive function in AD. Although the literature lacked sufficient evidence to support precise PA guidelines, convergent evidence does suggest that the incorporation of regular PA into daily routines mitigates AD-related symptoms, especially when deployed earlier in the disease process. Here the protocols used to alter the progression of AD-related neuropathology and cognitive decline are highlighted, and the implications for physical therapist practice are discussed.

Activity Engagement in Cognitive Aging: A Review of the Evidence

2013 ◽  
Vol 23 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Yvonne Rogalski ◽  
Muriel Quintana
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Aging ◽  
Social Activity ◽  
Current Evidence ◽  
Omega 3 ◽  
Neuroprotective Effects ◽  
Activity Engagement ◽  
Age Related ◽  
Age Related Cognitive Decline

The population of older adults is rapidly increasing, as is the number and type of products and interventions proposed to prevent or reduce the risk of age-related cognitive decline. Advocacy and prevention are part of the American Speech-Language-Hearing Association’s (ASHA’s) scope of practice documents, and speech-language pathologists must have basic awareness of the evidence contributing to healthy cognitive aging. In this article, we provide a brief overview outlining the evidence on activity engagement and its effects on cognition in older adults. We explore the current evidence around the activities of eating and drinking with a discussion on the potential benefits of omega-3 fatty acids, polyphenols, alcohol, and coffee. We investigate the evidence on the hypothesized neuroprotective effects of social activity, the evidence on computerized cognitive training, and the emerging behavioral and neuroimaging evidence on physical activity. We conclude that actively aging using a combination of several strategies may be our best line of defense against cognitive decline.

Different rates of cognitive decline in autosomal dominant and late‐onset Alzheimer disease

2021 ◽  
Author(s):  
Virginia D. Buckles ◽  
Chengjie Xiong ◽  
Randall J. Bateman ◽  
Jason Hassenstab ◽  
Ricardo Allegri ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Autosomal Dominant ◽  
Late Onset

scholarly journals The Rate of Cognitive Decline and Risk of Reaching Clinical Milestones in Alzheimer Disease

2003 ◽  
Vol 60 (8) ◽  
pp. 1137 ◽  
Author(s):  
Roee Holtzer ◽  
Domonick J. Wegesin ◽  
Steven M. Albert ◽  
Karen Marder ◽  
Karen Bell ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline

scholarly journals Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease

2016 ◽  
Vol 73 (4) ◽  
pp. 431 ◽  
Author(s):  
Daniel C. Aguirre-Acevedo ◽  
Francisco Lopera ◽  
Eliana Henao ◽  
Victoria Tirado ◽  
Claudia Muñoz ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Autosomal Dominant

Cognitive decline in Alzheimer disease: Impact of spirituality, religiosity, and QOL

Neurology ◽  
2007 ◽  
Vol 68 (18) ◽  
pp. 1509-1514 ◽  
Author(s):  
Y. Kaufman ◽  
D. Anaki ◽  
M. Binns ◽  
M. Freedman
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Disease Impact

scholarly journals Effects of Diabetes Mellitus on Cognitive Decline in Patients with Alzheimer Disease: A Systematic Review

2017 ◽  
Vol 41 (1) ◽  
pp. 114-119 ◽  
Author(s):  
Jun Li ◽  
Matteo Cesari ◽  
Fei Liu ◽  
Birong Dong ◽  
Bruno Vellas
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Alzheimer Disease ◽  
Cognitive Decline

scholarly journals Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

Autophagy ◽  
2019 ◽  
Vol 16 (1) ◽  
pp. 52-69 ◽  
Author(s):  
Rongcan Luo ◽  
Ling-Yan Su ◽  
Guiyu Li ◽  
Jing Yang ◽  
Qianjin Liu ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Murine Model

scholarly journals Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease

2015 ◽  
Vol 72 (3) ◽  
pp. 284 ◽  
Author(s):  
Robert H. Pietrzak ◽  
Yen Ying Lim ◽  
Alexander Neumeister ◽  
David Ames ◽  
Kathryn A. Ellis ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Decline ◽  
Amyloid Β
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