scholarly journals Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

Cureus ◽  
2020 ◽  
Author(s):  
Yahya A Alzahrani ◽  
Malak A Algarni ◽  
Maryam M Alnashri ◽  
Hanan M AlSayyad ◽  
Khadijah M Aljahdali ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sectional Study ◽  
Cell Disease ◽  
Cross Sectional ◽  
King Abdulaziz University

scholarly journals Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease in the King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

2019 ◽  
Author(s):  
Yahya A Alzahrani ◽  
Malak Ali Algarni ◽  
Maryam Mohammed Alnashri ◽  
Hanan Mohammad AlSayyad ◽  
Khadijah Mohammed Aljahdali ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Pediatric Population ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Cross Sectional ◽  
King Abdulaziz University

Abstract Objectives Studies have not addressed microalbuminuria in the sickle cell disease (SCD) pediatric population in Jeddah, Saudi Arabia. This study aimed to determine the prevalence of microalbuminuria and to identify associated risk factors in children with SCD in the King Abdulaziz University Hospital.Results Overall, 42.5% of the patients enrolled were Saudi Arabian and 51% were boys. Patients’ mean age was 12.4 years, and the highest percentage (40%) was in the age group of 15–18 years. The prevalence of microalbuminuria was 9.6%, and hematuria was present in 8% of cases. The percentage of patients with hematuria in the microalbuminuria group (22.6%) was significantly higher than that in the non-microalbuminuria group (6.5%) (P=.007). The percentage of patients with acute chest syndrome was higher in the microalbuminuria group (26%) than in the non-microalbuminuria group (8%) (P=0.005). The percentage of patients with gallbladder stones was higher in the microalbuminuria group (13%) than in the non-microalbuminuria group (2.4%) (P=.014). The mean number of blood transfusions was higher in the non-microalbuminuria group than in the microalbuminuria group (P=.002). Sickle cell nephropathy manifests as microalbuminuria, begins in the early ages of life, occurs in all types of SCD, and is associated with disease severity.

scholarly journals Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

2019 ◽  
Author(s):  
Yahya A Alzahrani ◽  
Malak Ali Algarni ◽  
Maryam Mohammed Alnashri ◽  
Hanan Mohammad AlSayyad ◽  
Khadijah Mohammed Aljahdali ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
Cross Sectional ◽  
King Abdulaziz University ◽  
Associated Risk Factors

Abstract Objectives Previous studies have not addressed microalbuminuria in pediatric patients with sickle cell disease (SCD) in Jeddah, Saudi Arabia. This study aimed to determine the prevalence of microalbuminuria and identify associated risk factors in children with SCD at King Abdulaziz University Hospital.Results Overall, 42.5% of the patients enrolled were Saudi Arabian and 51% were male. The patients’ mean age was 12.4 years, and the highest percentage (40%) was in the age group of 15–18 years. The prevalence of microalbuminuria was 9.6%, and hematuria was present in 8% of cases. The percentage of patients with hematuria was significantly higher in the microalbuminuria group (22.6%) than in the non-microalbuminuria group (6.5%; P=.007). The percentage of patients with acute chest syndrome was also higher in the microalbuminuria group (26%) than in the non-microalbuminuria group (8%; P=0.005). The percentage of patients with gallbladder stones was higher in the microalbuminuria group (13%) than in the non-microalbuminuria group (2.4%; P=.014). However, the mean number of blood transfusions was higher in the non-microalbuminuria group than in the microalbuminuria group (P=.002). Sickle cell nephropathy manifests as microalbuminuria, begins at an early age, occurs in all types of SCD, and is associated with disease severity.

scholarly journals Sexual Maturity in Adolescents Suffering from Sickle Cell Disease: A Cross-sectional Study

2021 ◽  
Author(s):  
Vijay Shah ◽  
Akash Patel ◽  
Praful Bambharoliya ◽  
Jigisha Patadia
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sexual Maturity ◽  
Tanner Stage ◽  
Cross Sectional Study ◽  
Reproductive Capacity ◽  
Sectional Study ◽  
Cell Disease ◽  
Cross Sectional ◽  
The Mean

Introduction: Sickle Cell Disease (SCD) is an inherited chronic haemolytic anaemia. The diseased person suffers from various complications such as anaemia, frequent infection, fever, hand-foot syndrome, stroke, etc. Puberty changes includes the appearance of the secondary sexual characteristics, increase in height, change in body composition and development of reproductive capacity. Aim: To study the sexual maturity and effect of multiple blood transfusions in adolescents suffering from SCD. Materials and Methods: It was a cross-sectional study conducted on 35 adolescents of age group 11 to 15 years, suffering from SCD. Study was conducted over a period of six months from March 2018 to September 2018 at Department of Paediatrics. SCD was diagnosed by Haemoglobin (Hb) electrophoresis. Weight and height were measured of all the participants. For assessing the sexual maturity, Tanners staging was used. Unpaired t-test was done for data analysis. Results: The mean age of the patients was 13.03±1.7 years. There were 25 males and 10 females. The mean age of male patients between Tanner stage 2(14.63±0.52 years) and Tanner stage 3 (14.75±0.5 years) was significantly higher than the Indian data for males (11.3 and 12.8 years, respectively). The mean age of female patients between Tanner stages 2 (13.5±2.12 years) and Tanner stage 3 (14.33±1.16 years) was higher than the Indian reference data for girls (10.2 and 11.6 years respectively). Conclusion: This study concluded that adolescents with SCD were significantly shorter in height and weight than the standard reference population. Sexual maturity is delayed in adolescents with sickle cell anaemia.

scholarly journals Asymmetric Dimethyl Arginine Level in Children with Sickle Cell Disease: A Cross Sectional Study

2021 ◽  
pp. 93-98
Author(s):  
Seham Fathy Khedr ◽  
Mohamed Hosny El Bradaey ◽  
Hala Mohamed Nagy ◽  
Mohamed Ramadan El-Shanshory ◽  
Eslam Elhawary
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cell Disease ◽  
Adma Level ◽  
Cross Sectional ◽  
Asymmetric Dimethyl Arginine ◽  
Dimethyl Arginine

Background: Sickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals inherit hemoglobin variants derived from single point mutations. Asymmetric dimethylarginine (ADMA) contributes to limiting Nitric Oxide (NO)  bioavailability in SCD. The aim of the present study was to assess the level of the Asymmetric Dimethyl Arginine in children with sickle cell. Methods: This cohort cross-sectional study was carried out on 60 children which were divided in to 3 equal groups. Group I: SCD children with sickle retinopathy. Group II: SCD children without retinopathy. Group III: healthy control children who were selected from the outpatient clinic. Results: There was a significant increase in ADMA level among participants withSCD. There was a positive significant correlation between ADMA  level and family history as well as the  incidence of hepatomegaly. There was no significant correlation between ADMA level and demographic and laboratory parameters except LDH. Conclusions: The level of ADMA is elevated in children with sickle cell anemia. High plasma ADMA level is a risk for hepatomegaly in children with sickle cell anemia.

scholarly journals A cross sectional study of growth of children with sickle cell disease, aged 2 to 5 years in Yaoundé, Cameroon

2019 ◽  
Vol 34 ◽  
Author(s):  
Suzanne Sap Ngo Um ◽  
Judith Seungue ◽  
Anastasie Yanda Alima ◽  
Ritha Mbono ◽  
Hubert Mbassi ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cell Disease ◽  
Cross Sectional

Perceptions about Sickle Cell Disease among Adults in Al Baha Region : A Cross-Sectional Study

2018 ◽  
Vol 70 (2) ◽  
pp. 357-363 ◽  
Author(s):  
Abdulrahman A. M. Alghamdi ◽  
Ali M. A. Alamri ◽  
Abdulrahman H. A. Alghamdi
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cell Disease ◽  
Cross Sectional

Osteonecrosis in sickle cell disease patients from Bahia, Brazil: a cross-sectional study

2018 ◽  
Vol 42 (7) ◽  
pp. 1527-1534 ◽  
Author(s):  
Gildasio Daltro ◽  
Bruno Adelmo Franco ◽  
Thiago Batista Faleiro ◽  
Davi Araujo Veiga Rosário ◽  
Paula Braga Daltro ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cell Disease ◽  
Cross Sectional

scholarly journals Mildly raised tricuspid regurgitant velocity 2.5–3.0 m/s in pregnant women with sickle cell disease is not associated with poor obstetric outcome – An observational cross-sectional study

2016 ◽  
Vol 9 (4) ◽  
pp. 160-163 ◽  
Author(s):  
May C Soh ◽  
Srividhya Sankaran ◽  
Natali YA Chung ◽  
Catherine Nelson-Piercy ◽  
Jo Howard ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Sickle Cell Disease ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cell Disease ◽  
Tertiary Referral Centre ◽  
Cross Sectional ◽  
In Pregnancy

Pulmonary hypertension is associated with 36% mortality in pregnancy, and 6–10% of patients with sickle cell disease have pulmonary hypertension. Tricuspid regurgitant velocity ≥2.5 m/s on echocardiography is a well validated means of screening for pulmonary hypertension in the non-pregnant population. This is a pilot study to determine if this is a useful non-invasive screening test for pulmonary hypertension in pregnancy, and whether raised tricuspid regurgitant velocity ≥2.5 m/s was associated with poor outcomes. This is a cross-sectional study over a five-year period in a tertiary referral centre with a specialised multidisciplinary clinic for pregnant women with sickle cell disease. Women with sickle cell disease, no prior pulmonary hypertension and singleton pregnancies who had echocardiography with a measurable tricuspid regurgitant velocity in pregnancy were included. There were 34 pregnancies, of which eight had tricuspid regurgitant velocity ≥2.5 m/s. There were no significant differences in their characteristics, sickle cell-related complications or medical co-morbidities. The women with tricuspid regurgitant velocity ≥2.5 m/s had similar obstetric and perinatal outcomes as those with a tricuspid regurgitant velocity <2.5 m/s.

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