scholarly journals A Multidisciplinary Approach to the Management of Severe Purpura Fulminans in a Burn Center: A Case Series

Cureus ◽  
2019 ◽  
Author(s):  
Mohammed Asif ◽  
Luis Quiroga ◽  
Tomer Lagziel ◽  
Seth B Ladd ◽  
Julie Caffrey
2008 ◽  
Vol 29 (2) ◽  
pp. 411-415 ◽  
Author(s):  
Zaheed Hassan ◽  
Robert F. Mullins ◽  
Bruce C. Friedman ◽  
Joseph R. Shaver ◽  
Badrul Alam ◽  
...  

2021 ◽  
Author(s):  
Mya Abousy ◽  
Scott Sylvester ◽  
David Milek ◽  
C. Scott Hultman ◽  
Julie Caffrey

2010 ◽  
Vol 86 ◽  
pp. S32-S33
Author(s):  
Melek Akar ◽  
Gamze Demirel ◽  
Gonca Sandal ◽  
Omer Erdeve ◽  
Nurdan Uras ◽  
...  

Burns ◽  
2019 ◽  
Vol 45 (1) ◽  
pp. 241-246 ◽  
Author(s):  
David N. Dado ◽  
Benjamin Huang ◽  
Daniel V. Foster ◽  
Jamison S. Nielsen ◽  
Jennifer M. Gurney ◽  
...  

F1000Research ◽  
2020 ◽  
Vol 8 ◽  
pp. 756
Author(s):  
Gleicy Gabriela Vitória Spinola Carneiro Falcão ◽  
Liliane Lins-Kusterer ◽  
Patricia Miranda Leite-Ribeiro ◽  
Viviane Almeida Sarmento

Dentists play a fundamental role in the early diagnosis of oral leishmaniasis. Although these lesions are rare at oral mucosa, this is one of the manifestations sites of the disease This study reports seven clinical cases of orofacial mucocutaneous leishmaniasis. All had leishmaniasis diagnosis confirmed by laboratory tests, with orofacial involvement. Five out of the seven cases were males, and in four cases, patients had associated comorbidities. Late diagnosis was observed, resulting in treatment delay and increased hospitalization stay. One patient had severe psychological consequences due to facial deformity. The lack of differential diagnosis due the great variability of clinical presentation of the lesions and frequent unspecific histopathology represent a challenge for the dentist. In two reported cases, there were unspecific biopsy results. This series of cases highlights the importance of a multidisciplinary approach in the diagnosis and treatment of oral and perioral leishmaniasis. Patients with atypical lesions, originating from or living in endemic regions, should be investigated for leishmaniasis. These procedures could avoid delays in diagnosis and decrease the risk of disease dissemination.


CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A1023
Author(s):  
Nicholas Hodgeman ◽  
Kevin Loudermilk ◽  
Anthony Basel

2020 ◽  
Vol 50 (4) ◽  
pp. 330-334
Author(s):  
Sumayya Abdul Kalam ◽  
Ronald AB Carey ◽  
John Antony ◽  
OC Abraham

Acute infectious purpura fulminans is a serious, potentially fatal condition. We present a case series of 11 patients from March 2005 to March 2017, whose clinical symptoms were fever (100%), confusion (63.6%) and headache (55%), and whose common laboratory abnormalities were thrombocytopenia (100%), elevated alkaline phosphatase (70%) and anaemia (63.6%). Three patients (27%) developed gangrene and two presented in shock. Only one grew Neisseria meningitidis in cerebrospinal fluid (CSF) culture and another confirmed by latex agglutination and polymerase chain reaction in CSF. Five others had serology confirmed spotted fever rickettsioses (SFG). All received broad spectrum antibiotics; in 9/11 patients, this included doxycycline or azithromycin. The mean hospital stay was 10.2 days and overall mortality was 18.2%.


Neurosurgery ◽  
2015 ◽  
Vol 77 (5) ◽  
pp. 718-725 ◽  
Author(s):  
Lida Mirzaei ◽  
Suzanne E.J. Kaal ◽  
Hendrik W.B. Schreuder ◽  
Ronald H.M.A. Bartels

Abstract BACKGROUND: The vertebral column is an infrequent site of primary involvement in Ewing sarcoma. Yet when Ewing sarcoma is found in the spine, the urge for decompression is high because of the often symptomatic compression of neural structures. It is unclear in alleviating a neurological deficit whether chemotherapy is preferred over decompressive laminectomy. OBJECTIVE: To underline, in this case series, the efficiency of initial chemotherapy before upfront surgery in the setting of high-grade spinal cord or cauda equina compression of primary Ewing sarcoma. METHODS: Fifteen patients with Ewing sarcoma primarily located in the spine were treated at our institution between 1983 and 2015. Localization, neurological deficit expressed as Frankel grade, and outcome expressed as Rankin scale before and after initial chemotherapy, the recurrence rate, and overall survival were evaluated. The multidisciplinary approach of 1 case will be discussed in detail. RESULTS: Nine patients (60%) were female. The age at presentation was 15.0 ± 5.5 years (range: 0.9–22.8 years). Ten patients (67%) were initially treated with chemotherapy, and 1 patient (7%) was treated primarily with radiotherapy followed by chemotherapy. The remaining 4 patients (27%) were initially treated with decompressive surgery. All patients treated primarily nonsurgically improved neurologically at follow-up, showing the importance of chemotherapy as an effective initial treatment option. CONCLUSION: Adequate and quick decompression of neural structures with similar results can be achieved by chemotherapy and radiotherapy, avoiding the local spill of malignant cells.


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