scholarly journals Diagnostic Accuracy of Xpert MTB/RIF in Sputum Smear-Negative Pulmonary Tuberculosis

Cureus ◽  
2019 ◽  
Author(s):  
Waqas Rasheed ◽  
Nisar Ahmed Rao ◽  
Hatem Adel ◽  
Mirza Saifullah Baig ◽  
Syed Omair Adil
Keyword(s):  
Pulmonary Tuberculosis ◽  
Diagnostic Accuracy ◽  
Sputum Smear ◽  
Smear Negative

scholarly journals Diagnosing sputum smear negative pulmonary tuberculosis patients by transbronchial biopsy and bronchoalveolar lavage smear.

2020 ◽  
Vol 27 (03) ◽  
pp. 499-505
Author(s):  
Mahwish Niaz ◽  
Mumtaz Ahmad ◽  
Kanwal Fatima ◽  
Faiza Kazi ◽  
Hassan Salim ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Diagnostic Accuracy ◽  
Bronchoalveolar Lavage ◽  
Disease Transmission ◽  
Predictive Value ◽  
Transbronchial Biopsy ◽  
Sputum Smear ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Smear Negative

Pulmonary tuberculosis is one of the leading causes of infectious disease related mortality. Transbonchial biopsy and bronchoalveolar lavage smear obtained by bronchoscopy provides greater quantity of material for analysis, thus increases the chances of diagnosing the disease. Objectives: To diagnose sputum smear negative pulmonary tuberculosis patients by Transbronchial Biopsy and Bronchoalveolar smear keeping bronchoalvelar lavage culture as gold standard. To calculate and compare the diagnostic accuracy of transbronchial biopsy and bronchoalveolar lavage smear in sputum negative patients. Study Design: Cross-sectional validation study. Setting: Department of histopathology, Foundation University Medical College, Islamabad and Department of Pulmonology and Microbiology, Fauji Foundation Hospital, Rawalpindi. Period: From May 2016 to May 2017. Materials & Methods: It comprised 96 patients who underwent bronchoscopy. Transbronchial biopsy, bronchoalveolar lavage smear preparation and bronchoalveolar lavage culture was performed on specimens of all patients. Results: Out of 96 patients 22 (22.91%) patients were actually having tuberculosis whereas 74 (77%) had only clinical and radiological suspicion of tuberculosis. The mean age of patients was 43 years with a standard deviation of ±19.1 .The age range was 12-80 years. The sensitivity, specificity, positive predictive value, negative predictive value and true positives of transbronchial biopsy were 68.1%, 77%, 46.8%, 89% and15.62% while the values for bronchoalveolar lavage were 50%, 97.29%, 84.6%, 86.7% and 11.45% respectively. Thus, the diagnostic accuracy calculated for transbronchial biopsy and bronchoalveolar lavage was 75% and 13.54% respectively. Conclusions: Bronchoscopy should be done in all sputum negative tuberculosis patients having strong clinical and radiological suspicion to obtain transbronchial biopsy and bronchoalveolar lavage for timely diagnosis, treatment and prevention of disease transmission as well as to avoid empirical treatment and its side effects in patients having no tuberculosis. The diagnostic accuracy of transbronchial biopsy is almost 5 times more compared to bronchoalveolar lavage smear.

scholarly journals Contribution of Gene-Xpert in the Diagnosis of Negative Microscopy Pulmonary Tuberculosis in Brazzaville, Republic Of Congo

2020 ◽  
pp. 1-8
Author(s):  
Laure Stella Ghoma Linguissi ◽  
◽  
Clément Armand Nyanga-Koumou ◽  
Christ Eya ◽  
◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Diagnostic Accuracy ◽  
World Health ◽  
Sputum Smear ◽  
Published Data ◽  
National Guidelines ◽  
Republic Of Congo ◽  
Middle Income ◽  
Standard Design ◽  
Smear Negative

Setting: Xpert MTB/Rif has become an integral part of tuberculosis diagnostic algorithms in many low- and middle-income countries and no published data was retrieved regarding the diagnostic accuracy of Xpert MTB/RIF in sputum smear-negative pulmonary TB in RoC. Objectives: This study aimed at determining the diagnostic accuracy of Xpert MTB/RIF in diagnosing sputum smear-negative pulmonary tuberculosis keeping AFB microscopy as the gold standard. Design: For 4 months, one morning sputum smear was performed for every TB suspect (cough lasting >3 weeks, as defined in Congolese’s national guidelines) with AFB microscopy and GeneXpert. Results: Of 90 TB suspects for whom AFB microscopy and GeneXpert were performed, 79 (87.78%) sputum smear-negative 17 (21.52%) GeneXpert positive cases were identified. During the study, 11 (12.22%) sputum smear-positive cases were diagnosed. GeneXpert has greatly contributed to increasing the total number of bacteriologically proven cases. Conclusion: These results confirms the utility of GeneXpert in the diagnosis of tuberculosis especially smear negative pulmonary tuberculosis, and demonstrates that the expected number of smear-negative TB cases in Republic of Congo is probably much higher than the World Health Organization’s current annual estimates

Role of fibreoptic bronchoscopy in sputum smear negative pulmonary tuberculosis

1994 ◽  
Vol 75 ◽  
pp. 29
Author(s):  
A. McDaniel ◽  
N. Schoenfeld ◽  
W. Frank ◽  
A. Grassot ◽  
H. Mauch ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Fibreoptic Bronchoscopy ◽  
Sputum Smear ◽  
Smear Negative

Diagnosis of sputum smear-negative forms of pulmonary tuberculosis by transthoracic fine-needle aspiration

Tubercle ◽  
1991 ◽  
Vol 72 (3) ◽  
pp. 210-213 ◽  
Author(s):  
I. Gomes ◽  
E. Trindade ◽  
O. Vidal ◽  
O. Yeep ◽  
I. Amendoeirai ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Sputum Smear ◽  
Fine Needle ◽  
Smear Negative

Evaluation of a Diagnostic Algorithm for Sputum Smear–Negative Pulmonary Tuberculosis in HIV-Infected Adults

2013 ◽  
Vol 63 (3) ◽  
pp. 331-338 ◽  
Author(s):  
Chandrasekaran Padmapriyadarsini ◽  
Srikanth Tripathy ◽  
Lakshmanan Sekar ◽  
Perumal Kannabiran Bhavani ◽  
Nitin Gaikwad ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Diagnostic Algorithm ◽  
Sputum Smear ◽  
Smear Negative
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