scholarly journals Replication Study of Polymorphisms Associated With Brain Arteriovenous Malformation in a Population From South of Brazil

Cureus ◽  
2016 ◽  
Author(s):  
André Cerutti Franciscatto ◽  
Fernanda S Ludwig ◽  
Ursula S Matte ◽  
Simone Mota ◽  
Marco A Stefani
Keyword(s):  
Arteriovenous Malformation ◽  
Replication Study ◽  
Brain Arteriovenous Malformation ◽  
South Of Brazil

Susceptibility loci for sporadic brain arteriovenous malformation; a replication study and meta-analysis

2015 ◽  
Vol 87 (7) ◽  
pp. 693-696 ◽  
Author(s):  
P H C Kremer ◽  
B P C Koeleman ◽  
G JE Rinkel ◽  
F P Diekstra ◽  
L H van den Berg ◽  
...  
Keyword(s):  
Arteriovenous Malformation ◽  
Meta Analysis ◽  
Replication Study ◽  
Susceptibility Loci ◽  
Brain Arteriovenous Malformation

Value of cone beam computed tomography to evaluate complication of intracranial haemorrhage in endovascular treatment (evt): a case report

2019 ◽  
Vol 1 (1) ◽  
pp. 16-18 ◽  
Author(s):  
Norafida Bahari ◽  
Nik Azuan Nik Ismail ◽  
Jegan Thanabalan ◽  
Ahmad Sobri Muda
Keyword(s):  
Computed Tomography ◽  
Arteriovenous Malformation ◽  
Endovascular Treatment ◽  
Cone Beam Computed Tomography ◽  
Diagnostic Value ◽  
Cone Beam ◽  
Brain Arteriovenous Malformation ◽  
Embolic Materials

In this article, we evaluate the effectiveness of Cone Beam Computed Tomography, through a case study, in assessing the complication of intracranial bleeding during an endovascular treatment of brain arteriovenous malformation when compared to Multislice-Detector Computed Tomography performed immediately after the procedure. The image quality of Cone Beam Computed Tomography has enough diagnostic value in differentiating between haemorrhage, embolic materials and the arteriovenous malformation nidus to facilitate physicians to decide for further management of the patient.

Value of cone beam computed tomography to evaluate complication of intracranial haemorrhage in endovascular treatment (evt): a case report.

2019 ◽  
pp. 16-18
Author(s):  
Norafida Bahari ◽  
NikAzuan Nik Ismail ◽  
Jegan Thanabalan ◽  
Ahmad Sobri Muda
Keyword(s):  
Computed Tomography ◽  
Arteriovenous Malformation ◽  
Endovascular Treatment ◽  
Cone Beam Computed Tomography ◽  
Diagnostic Value ◽  
Cone Beam ◽  
Brain Arteriovenous Malformation ◽  
Embolic Materials

In this article, we evaluate the effectiveness of Cone Beam Computed Tomography, through a case study, in assessing the complication of intracranial bleeding during an endovascular treatment of brain arteriovenous malformation when compared to Multislice-Detector Computed Tomography performed immediately after the procedure. The image quality of Cone Beam Computed Tomography has enough diagnostic value in differentiating between haemorrhage, embolic materials and the arteriovenous malformation nidus to facilitate physicians to decide for further management of the patient.

Decision-Making in the Scheduling of Endovascular Treatment after Brain Arteriovenous Malformation Haemorrhage: A Retrospective Single Centre Study

2011 ◽  
Vol 24 (6) ◽  
pp. 879-885 ◽  
Author(s):  
J.J. Downer ◽  
M. Cellerini ◽  
R.A. Corkill ◽  
S. Lalloo ◽  
W. Küker ◽  
...  
Keyword(s):  
Early Intervention ◽  
High Risk ◽  
Arteriovenous Malformation ◽  
Endovascular Treatment ◽  
Complication Rate ◽  
Injury Severity ◽  
Endovascular Intervention ◽  
Brain Arteriovenous Malformation ◽  
Single Centre ◽  
Significant Difference

The appropriate timing for endovascular intervention after brain arteriovenous malformation (bAVM) rupture is not known. This paper aims to determine factors that lead to early endovascular intervention and to investigate whether early intervention has the same complication rate as late intervention in a single centre. All patients who underwent endovascular treatment for a ruptured bAVM at our institution in the period January 2007 and July 2010 were included in this retrospective observational study. Of 50 patients, 33 had early endovascular intervention, defined as within 30 days of haemorrhage and the remaining 17 patients had endovascular treatment at day 30 or beyond. A greater proportion of patients treated within the first 30 days were in neurointensive care preoperatively (51.5% vs. 23.5%, p=0.07). A ‘high-risk’ angioarchitectural feature was identified in more patients who had acute intervention (78.8% vs. 11.8%, p<0.0001) and targeted embolization was also more frequent in this group (48.5% vs. 5.9%, p=0.004). Nidal aneurysms, venous varices and impaired venous outflow (venous stenosis) were the principal ‘high risk’ features. Clinically apparent complications occurred in 10.8% of procedures with permanent neurological deficit in 3.6%. There was no directly procedure-related mortality. There was no statistically significant difference in the complication rate of early procedures compared with delayed interventions (12.5% vs. 7.4%, p=0.71). Greater initial injury severity and the presence of high-risk lesion characteristics are the factors that lead to early endovascular intervention. Early intervention is associated with a higher complication rate, but this difference is not statistically significant.

scholarly journals Effect of Age on Clinical and Morphological Characteristics in Patients With Brain Arteriovenous Malformation

Stroke ◽  
2003 ◽  
Vol 34 (11) ◽  
pp. 2664-2669 ◽  
Author(s):  
C. Stapf ◽  
A.V. Khaw ◽  
R.R. Sciacca ◽  
C. Hofmeister ◽  
H.C. Schumacher ◽  
...  
Keyword(s):  
Arteriovenous Malformation ◽  
Morphological Characteristics ◽  
Brain Arteriovenous Malformation ◽  
Effect Of Age

scholarly journals Demographic, Morphological, and Clinical Characteristics of 1289 Patients With Brain Arteriovenous Malformation

Stroke ◽  
2000 ◽  
Vol 31 (6) ◽  
pp. 1307-1310 ◽  
Author(s):  
C. Hofmeister ◽  
C. Stapf ◽  
A. Hartmann ◽  
R. R. Sciacca ◽  
U. Mansmann ◽  
...  
Keyword(s):  
Arteriovenous Malformation ◽  
Clinical Characteristics ◽  
Brain Arteriovenous Malformation

A Reanalysis of Predictors for the Risk of Hemorrhage in Brain Arteriovenous Malformation

2018 ◽  
Vol 27 (8) ◽  
pp. 2082-2087 ◽  
Author(s):  
Zheng Huang ◽  
Kang Peng ◽  
Changqing Chen ◽  
Feiyue Zeng ◽  
Junyu Wang ◽  
...  
Keyword(s):  
Arteriovenous Malformation ◽  
Brain Arteriovenous Malformation ◽  
Risk Of Hemorrhage

Abstract 3666: Common Polymorphisms in Familial Vascular Malformation Genes do not Show Association with Sporadic Brain Arteriovenous Malformation

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Shantel Weinsheimer ◽  
Nasrine Bendjilali ◽  
Ludmila Pawlikowska ◽  
Pui-Yan Kwok ◽  
Michael T Lawton ◽  
...  
Keyword(s):  
Arteriovenous Malformation ◽  
Vascular Malformation ◽  
Multiple Testing ◽  
Nucleotide Polymorphisms ◽  
Brain Arteriovenous Malformation ◽  
Inherited Disorders ◽  
Venous Circulation ◽  
Snp Association ◽  
Number Variation ◽  
Genome Wide Data

Background: The genetic basis of brain arteriovenous malformation (BAVM), a tangle of abnormal vessels directly shunting blood from the arterial to venous circulation, is unknown. However, there are two rare vascular disorders with known familial mutations in which a subset of patients display a BAVM phenotype: hereditary hemorrhagic telangiectasia ( ACVRL1 , ENG , and SMAD4 mutations) and capillary malformation-arteriovenous malformation ( RASA1 mutations). To investigate whether variants in these four vascular malformation genes are associated with sporadic BAVM, we performed a case-control study, evaluating both single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Methods: We used genome-wide data (Affymetrix SNP 6.0) from 319 cases and 496 healthy controls. There were 27 unlinked SNPs (r 2 <0.8) on the array with minor allele frequency >1% and in Hardy-Weinberg equilibrium (p>0.01) mapping within 20kb of the four genes: ACVRL1 (n=16), ENG (n=6), SMAD4 (n=2), and RASA1 (n=3). Single SNP association was tested using multivariate logistic regression in PLINK, adjusting for age, gender, and top 3 principal components of ancestry (to control for population stratification). The Bonferroni method (p<0.0019) was used to correct for multiple comparisons. CNVs in these genes were called using the PennCNV algorithm. Results: Two SNPs located upstream and downstream of ACVRL1 were associated with BAVM at nominal p<0.05: rs10783480 (OR=0.69, 95% CI=0.50 - 0.96, p=0.029,) and rs11169956 (OR=0.69, 95% CI=0.48 - 0.99, p=0.046). However, these SNPs were not associated with BAVM after correction for multiple testing of all SNPs. Polymorphisms in the RASA1 , ENG , and SMAD4 genes were not significantly associated with BAVM (p>0.05). We observed one CNV, a duplication that mapped to the ACVRL1 gene, in one control. We did not observe any CNVs mapping to RASA1 , ENG , or SMAD4 . Conclusions: Common SNPs and CNVs in four vascular malformation genes associated with inherited disorders displaying BAVM were not significantly associated with sporadic BAVM. A previously reported ACVRL1 intronic SNP (rs2071219) was not on the Affymetrix array and none of the existing ACVRL1 SNPs tagged this SNP. Further, rare polymorphisms in these genes were not genotyped and may contribute to BAVM risk.

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