scholarly journals Clinical Behavior of Triple Negative Breast Cancer in a Cohort of Latin American Women

Cureus ◽  
2019 ◽  
Author(s):  
Sandra Diaz Casas ◽  
Eder Lancheros García ◽  
Andrés Sanchéz Campo ◽  
Ricardo Sanchez Pedraza ◽  
Vivian Roman Vasquez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Latin American ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Clinical Behavior ◽  
American Women

Abstract C092: Immune characteristics of triple-negative breast cancer (TNBC) in Latin American women from Colombia

2020 ◽  
Author(s):  
Valentina A. Zavala ◽  
Laura C. Carrasquilla ◽  
Silvia J. Serrano-Gomez ◽  
Maria C. Sanabria-Salas ◽  
Melody C. Baddoo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Latin American ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
American Women

Abstract 1465: Regulatory role of miRNA-661 in triple-negative breast cancer of African American women

2017 ◽  
Author(s):  
Aline S. Fonseca ◽  
Selene Elifio-Esposito ◽  
Marilesia F. Souza ◽  
Akanksha Mahajan ◽  
Yara R. Zabala ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Regulatory Role ◽  
American Women

scholarly journals LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women

2018 ◽  
Vol Volume 11 ◽  
pp. 1-12 ◽  
Author(s):  
Odalys Torres-Luquis ◽  
Krystal Madden ◽  
N'sanh MR N'dri ◽  
Richard Berg ◽  
Olufunmilayo F. Olopade ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
American Women

scholarly journals CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women

2021 ◽  
Author(s):  
Johnathan Abou-Fadel ◽  
Brian Grajeda ◽  
Xiaoting Jiang ◽  
Alyssa-Marie Cailing-De La O ◽  
Esmeralda Flores ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Breast Cancer Mortality ◽  
Signaling Network ◽  
American Women ◽  
Novel Biomarkers

Breast cancer is the most commonly diagnosed cancer worldwide and remains the second leading cause of cancer death. While breast cancer mortality has steadily declined over the past decades through medical advances, an alarming disparity in breast cancer mortality has emerged between African American women (AAW) and Caucasian American women (CAW); and new evidence suggests more aggressive behavior of triple-negative breast cancer (TNBC) in AAW may contribute to racial differences in tumor biology and mortality. Progesterone (PRG) is capable of exerting its cellular effects through either its classic, non-classic or combined responses through binding to either classic nuclear PRG receptors (nPRs) or non-classic membrane PRG receptors (mPRs), warranting both pathways an equally important status in PRG-mediated signaling. In our previous report, we demonstrated that the CCM signaling complex (CSC) consisting of CCM1, CCM2, and CCM3 proteins can couple both nPRs and mPRs signaling cascades to form a CSC-mPRs-PRG-nPRs (CmPn) signaling network in nPR positive(+) breast cancer cells. In this report, we furthered our research by establishing the CSC-mPRs-PRG (CmP) signaling network in nPR(-) breast cancer cells, demonstrating that a common core mechanism exists, regardless of nPR(+/-) cell type. This is the first report stating that inducible expression patterns exist between CCMs and major mPRs in TNBC cells. Furthermore, we firstly show mPRs in TNBC cells are localized in the nucleus and participate in nucleocytoplasmic shuttling in a coordinately synchronized fashion with CCM proteins under steroid actions, following the same cellular distribution as other well-defined steroid hormone receptors. Finally, for the first time, we deconvoluted the CmP signalosome by using multi-omics approaches, which helped us understand key factors within the CmP network, and identify 21 specific biomarkers with potential clinical applications associated with AAW-TNBC tumorigenesis. These novel biomarkers could have immediate clinical implications to dramatically improve health disparities among AAW-TNBCs.

scholarly journals Disrupting the CmP signaling network unveils novel biomarkers for triple negative breast cancer in Caucasian American women

2021 ◽  
Author(s):  
Johnathan Abou-Fadel ◽  
Muaz Bhalli ◽  
Brian Grajeda ◽  
Jun Zhang
Keyword(s):  
Breast Cancer ◽  
Racial Differences ◽  
Triple Negative Breast Cancer ◽  
Molecular Mechanisms ◽  
Triple Negative ◽  
Signaling Network ◽  
Caucasian American ◽  
American Women ◽  
Signaling Complex ◽  
Novel Biomarkers

Objective: Triple-negative breast cancer (TNBC) constitutes ~15 percent of all diagnosed invasive breast cancer cases with limited options for treatment since immunotherapies that target the ER, PR and HER2 receptors are ineffective. Progesterone (PRG) is capable of inducing its effects through either classic, non-classic, or combined responses by binding to classic nuclear PRG receptors (nPRs) or non-classic membrane PRG receptors (mPRs). Under PRG-induced actions, we previously demonstrated that the CSC (CCM signaling complex) can couple both nPRs and mPRs into a CmPn signaling network which plays an important role in nPR(+) breast cancer tumorigeneses. We recently defined the novel CmP signaling network in TNBC cells, which overlapped with our previously defined CmPn network in nPR(+) breast cancer cells. Materials and Methods: Under mPRs-specific steroid actions, we measured alterations to key tumorigenesis pathways in Caucasian American Women (CAW)-TNBC cells, with RNAseq and Proteomic approaches. Results: TNBC in CAW share similar altered signaling pathways, under mPRs-specific steroid actions, demonstrating the overall aggressive nature of TNBCs, regardless of racial differences. Furthermore, in this report, we have identified 21 new CAW-TNBC specific candidate biomarkers that reinforce the definitive role of the CmP signaling network in TNBC tumorigenesis, initially identified in our previous studies with AAW-TNBCs. This new set of potential prognostic biomarkers may revolutionize molecular mechanisms and currently known concepts of tumorigenesis in CAW-TNBCs, leading to hopeful new therapeutic strategies.

scholarly journals Integrated copy number and miRNA expression analysis in triple negative breast cancer of Latin American patients

Oncotarget ◽  
2019 ◽  
Vol 10 (58) ◽  
pp. 6184-6203 ◽  
Author(s):  
Bruna M. Sugita ◽  
Silma R. Pereira ◽  
Rodrigo C. de Almeida ◽  
Mandeep Gill ◽  
Akanksha Mahajan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Latin American ◽  
Expression Analysis ◽  
Triple Negative Breast Cancer ◽  
Mirna Expression ◽  
Copy Number ◽  
Triple Negative

scholarly journals Mass Spectrometry-Based Omics for the Characterization of Triple-Negative Breast Cancer Bio-Signature

2020 ◽  
Vol 10 (4) ◽  
pp. 277
Author(s):  
Ioana-Ecaterina Pralea ◽  
Radu-Cristian Moldovan ◽  
Adrian-Bogdan Țigu ◽  
Corina Ionescu ◽  
Cristina-Adela Iuga
Keyword(s):  
Breast Cancer ◽  
Mass Spectrometry ◽  
Overall Survival ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Biomarker Discovery ◽  
High Rate ◽  
Current Standard ◽  
Poor Overall Survival ◽  
Clinical Behavior

Triple-negative breast cancer (TNBC) represents an unmet medical need due to a high rate of metastatic occurrence and poor overall survival, pathology aggressiveness, heterogeneous clinical behavior and limited cytotoxic chemotherapy options available because of the absence of targetable receptors. The current standard of care in TNBC is represented by chemotherapy and surgery associated with low overall survival and high relapse rates. Hopes of overcoming current limited and unspecific approaches of TNBC therapy lie in studying the metabolic rewiring of these types of breast cancer, thus understanding the mechanisms involved in the occurrence and progression of the disease. Due to its heterogeneity, a clinically relevant sub-classification of this type of breast cancer based on biomarker panels is greatly needed in order to guide treatment decisions. Mass spectrometry-based omics may provide very useful tools to address the current needs of targetable biomarker discovery and validation. The present review aims to provide a comprehensive view of the current clinical diagnosis and therapy of TNBC highlighting the need for a new approach. Therefore, this paper offers a detailed mass spectrometry-based snapshot of TNBC metabolic adjustment, emphasizing a complex network of variables governing the diverse and aggressive clinical behavior of TNBC.

Clinical behavior of a cohort of patients with triple negative breast cancer

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 11576-11576
Author(s):  
R. Villalobos ◽  
G. Hernández ◽  
M. Martinez-Prieto
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Clinical Behavior
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