scholarly journals Oncogenic Osteomalacia with Elevated Fibroblast Growth Factor 23: A Rare Case of Paranasal Sinus Tumor Onset

Cureus ◽  
2019 ◽  
Author(s):  
Mario Rigante ◽  
Antonella Loperfido ◽  
Gaetano Paludetti
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Paranasal Sinus ◽  
Rare Case ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Oncogenic Osteomalacia ◽  
Tumor Onset ◽  
Paranasal Sinus Tumor ◽  
Sinus Tumor

scholarly journals Fibroblast Growth Factor 23-Producing Phosphaturic Mesenchymal Tumor with Extraordinary Morphology Causing Oncogenic Osteomalacia

Medicina ◽  
2020 ◽  
Vol 56 (1) ◽  
pp. 34
Author(s):  
Cornelia Then ◽  
Evelyn Asbach ◽  
Harald Bartsch ◽  
Niklas Thon ◽  
Christian Betz ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Olfactory Neuroblastoma ◽  
Mesenchymal Tumor ◽  
Fibroblast Growth ◽  
Phosphaturic Mesenchymal Tumor ◽  
Oncogenic Osteomalacia ◽  
Pet Ct ◽  
Fgf 23

A possible cause of hypophosphatemia is paraneoplastic secretion of fibroblast growth factor 23 (FGF-23). Tumors secreting FGF-23 are rare, mostly of mesenchymal origin, usually benign, and may be located anywhere in the body, including hands and feet, which are often not represented in conventional imaging. A 50-year-old woman presented with diffuse musculoskeletal pain and several fractures. Secondary causes of osteoporosis were excluded. Laboratory analysis revealed hypophosphatemia and elevated alkaline phosphatase, parathyroid hormone, and FGF-23. Thus, oncogenic osteomalacia due to neoplastic FGF-23 secretion was suspected. FDG-PET-CT and DOTATATE-PET-CT imaging demonstrated no tumor. Cranial MRI revealed a tumorous mass in the left cellulae ethmoidales. The tumor was resected and histopathological examination showed a cell-rich tumor with round to ovoid nuclei, sparse cytoplasm, and sparse matrix, resembling an olfactory neuroblastoma. Immunohistochemical analysis first led to diagnosis of olfactory neuroblastoma, which was later revised to phosphaturic mesenchymal tumor. Following the resection, FGF-23 and phosphate levels normalized. In conclusion, we here describe a patient with an FGF-23-secreting phosphaturic mesenchymal tumor with an unusual morphology. Furthermore, we emphasize diagnostic pitfalls when dealing with FGF-23-induced hypophosphatemia.

scholarly journals Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis

2012 ◽  
Vol 5 (3) ◽  
pp. 240-243 ◽  
Author(s):  
P.-A. Westerberg ◽  
T. Linde ◽  
D. Vanderschueren ◽  
J. Billen ◽  
I. Jans ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Oncogenic Osteomalacia ◽  
Phosphate Homeostasis

scholarly journals Localization of Oncogenic Osteomalacia by Systemic Venous Sampling of Fibroblast Growth Factor 23

2017 ◽  
Vol 58 (5) ◽  
pp. 981 ◽  
Author(s):  
Ji-Yeon Lee ◽  
Hye-Sun Park ◽  
Seunghee Han ◽  
Jiyu Kelly Lim ◽  
Namki Hong ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Oncogenic Osteomalacia ◽  
Venous Sampling

scholarly journals Tumour-induced Osteomalacia Secondary to a Sarcoma

2016 ◽  
Vol 12 (2) ◽  
pp. 104 ◽  
Author(s):  
Karla Victoria Rodriguez-Velver ◽  
◽  
◽  
◽  
◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Rare Case ◽  
Bone Fractures ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Biochemical Characteristics ◽  
History Of ◽  
Benign Tumours

Tumour-induced osteomalacia (TIO), is a rare paraneoplasatic syndrome found in >95% of benign tumours that secrete fibroblast growth factor 23 - a phosphaturic circulating hormone. A rare case of a TIO secondary to a sarcoma, in a 21-year old man with history of bone fractures and distinctive physical and biochemical characteristics is presented and discussed.

scholarly journals Fibroblast Growth Factor 23: A New Clinical Marker for Oncogenic Osteomalacia

2003 ◽  
Vol 88 (9) ◽  
pp. 4088-4094 ◽  
Author(s):  
Anne E. Nelson ◽  
Roderick Clifton Bligh ◽  
Michiko Mirams ◽  
Anthony Gill ◽  
Amy Au ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Oncogenic Osteomalacia ◽  
Clinical Marker

Fibroblast Growth Factor 23 in Oncogenic Osteomalacia and X-Linked Hypophosphatemia

2003 ◽  
Vol 348 (17) ◽  
pp. 1656-1663 ◽  
Author(s):  
Kenneth B. Jonsson ◽  
Richard Zahradnik ◽  
Tobias Larsson ◽  
Kenneth E. White ◽  
Toshitsugu Sugimoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Oncogenic Osteomalacia
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