scholarly journals Granular Cell Pituitary Tumor in a Patient with Multiple Endocrine Neoplasia-1

Cureus ◽  
2019 ◽  
Author(s):  
Arjun V Pendharkar ◽  
Chieh-Yu Lin ◽  
Donald E Born ◽  
Andrew R Hoffman ◽  
Robert L Dodd
Keyword(s):  
Pituitary Tumor ◽  
Multiple Endocrine Neoplasia ◽  
Granular Cell ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia 1

scholarly journals Parathyroid carcinoma occurred in two glands in multiple endocrine neoplasia 1: a report on a rare case

2018 ◽  
Vol 65 (2) ◽  
pp. 245-252 ◽  
Author(s):  
Yoko Omi ◽  
Kiyomi Horiuchi ◽  
Kento Haniu ◽  
Momoko Tokura ◽  
Erin Nagai ◽  
...  
Keyword(s):  
Parathyroid Carcinoma ◽  
Rare Case ◽  
Multiple Endocrine Neoplasia ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia 1

scholarly journals Unique Gene Expression Profile Associated with an Early-Onset Multiple Endocrine Neoplasia (MEN1)-Associated Pituitary Adenoma

2011 ◽  
Vol 96 (11) ◽  
pp. E1905-E1914 ◽  
Author(s):  
William E. Farrell ◽  
Monalisa F. Azevedo ◽  
Dalia L. Batista ◽  
Alastair Smith ◽  
Isabelle Bourdeau ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Expression Profile ◽  
Early Onset ◽  
Pituitary Tumor ◽  
Multiple Endocrine Neoplasia ◽  
Expression Profiles ◽  
Immunohistochemical Analysis ◽  
Tumor Formation ◽  
Tumor Evolution ◽  
Endocrine Neoplasia

Abstract Context: Multiple endocrine neoplasia type 1 (MEN1) is caused by mutations in the menin (MEN1) gene. The mechanism(s) by which MEN1 mutations lead to pituitary tumor formation remain(s) unknown. Objective: The aim of the study was to identify the pediatric MEN1-associated pituitary tumor transcriptome. Patients and Methods: A patient harboring a MEN1 mutation (c.525C>G; p.H139D) who presented with an early-onset mammosomatotroph pituitary adenoma was studied. Microarray analysis was performed in the tumor sample and compared with the profile observed in normal pituitaries and in a sporadic mammosomatotropinoma. Validation of the microarray results was performed using quantitative real-time PCR and immunohistochemical analysis for selected genes. Results: In the MEN1-associated pituitary adenoma, 59 and 24 genes were found to be significantly up- and down-regulated, respectively. The up-regulated genes included those involved in cell growth and maintenance, apoptosis, growth arrest, and tumorigenesis. Moreover, we observed decreased expression in genes neuroendocrine in nature and related to growth or apoptosis. Only 21 of the 59 genes differentially expressed in the MEN1-associated adenoma showed a similar expression profile to that seen in the sporadic mammosomatotropinoma; for some genes an opposite expression profile was observed. Conclusions: We identified changes in the transcriptome that occur in pituitary GH- and PRL-producing cells after the loss of menin expression; some of the gene changes are necessary for tumor evolution, and others may be tertiary. Nevertheless, the rare overlap between the expression profiles of the MEN1 tumor vs. that of its sporadic counterpart suggests that these tumors evolve along different molecular pathways.

scholarly journals Management of a Multiple Endocrine Neoplasia 1 Patient in Pregnancy

2020 ◽  
Vol 13 (4) ◽  
pp. 349
Author(s):  
Rajeev Chauhan ◽  
Deepanshu Dhiman ◽  
SummitDev Bloria ◽  
Pranshuta Sabharwal ◽  
Rashi Sarna
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia 1 ◽  
In Pregnancy
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