scholarly journals Cerebral Cavernous Angioma Associated with Klippel Trenaunay Syndrome Treated with Gamma Knife Radiosurgery: Case Report and Literature Review

Cureus ◽  
2019 ◽  
Author(s):  
M Abid Saleem ◽  
Noor E Zahra ◽  
Fatima Hemani ◽  
Abdullah Jan Ali ◽  
Aamir Gilani
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Cavernous Angioma ◽  
Klippel Trenaunay Syndrome

Cerebral and spinal cavernomas associated with Klippel-Trenaunay syndrome: case report and literature review

2017 ◽  
Vol 160 (2) ◽  
pp. 287-290 ◽  
Author(s):  
Takaya Yoshinaga ◽  
Kenji Yagi ◽  
Takashi Morishita ◽  
Hiroshi Abe ◽  
Masani Nonaka ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Spinal Cavernomas ◽  
Klippel Trenaunay Syndrome

scholarly journals Case Report: Dacomitinib Overcomes Osimertinib Resistance in NSCLC Patient Harboring L718Q Mutation: A Case Report

2021 ◽  
Vol 11 ◽  
Author(s):  
Qian Shen ◽  
Jingjing Qu ◽  
Zhen Chen ◽  
Jianying Zhou
Keyword(s):  
Case Report ◽  
Disease Progression ◽  
Gamma Knife ◽  
Parietal Lobe ◽  
Brain Mri ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Egfr Mutations ◽  
Small Subset ◽  
Small Cell Lung

BackgroundAdvanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations has been successfully treated with tyrosine kinase inhibitors (TKIs). However, resistance to osimertinib, a third-generation TKI, can be difficult to overcome in this small subset of patients and is attributed to secondary resistant mutations. Here, we report a case of acquired EGFR L858R/L718Q mutation with advanced NSCLC that resistant to osimertinib, which was successfully overcome using dacomitinib.Case PresentationA 64-year-old non-smoker woman was diagnosed with stage IV non-small cell lung adenocarcinoma with EGFR L858R mutation and brain metastasis in November 2018. Treatment with gefitinib and gamma knife radiosurgery was started as the first-line treatment. After 7 months, she experienced disease progression with increased primary lung lesions and switched to osimertinib based on an acquired EGFR T790M mutation. After another 4 months, the disease progressed, and she was switched to chemotherapy. During chemotherapy, brain MRI showed an increasing number of parietal lobe metastases. Hence, gamma knife radiosurgery was performed again. After 12 months, the disease progression resumed, and an EGFR L718Q mutation was found on biopsy. The patient was then challenged with dacomitinib, and the disease was partially responsive and under control for 6 months.ConclusionCurrently, there are no established guidelines for overcoming osimertinib resistance caused by the L718Q mutation. The acquired EGFR L718Q mutation in subsequent resistance to osimertinib could be overcome using dacomitinib, indicating a promising treatment option in the clinic.

Primary cavernous sinus malignant lymphoma treated by gamma knife radiosurgery: Case report and review of the literature

1996 ◽  
Vol 46 (3) ◽  
pp. 272-278 ◽  
Author(s):  
Hirofumi Nakatomi ◽  
Tomio Sasaki ◽  
Shunsuke Kawamoto ◽  
Takamitsu Fujimaki ◽  
Kazuhide Furuya ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Lymphoma ◽  
Gamma Knife ◽  
Cavernous Sinus ◽  
Gamma Knife Radiosurgery ◽  
Review Of The Literature
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