scholarly journals Gamma knife radiosurgery for breast cancer metastases to the brain: outcomes and prognostic factors from a large prospectively collected database

Cureus ◽  
2012 ◽  
Author(s):  
Aizik L Wolf ◽  
Kristin J Redmond ◽  
Pietro Bortoletto ◽  
Chetan Bettegowda ◽  
Beatriz E Amendola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
The Brain

Cytokeratin 7, GATA3, and SOX-10 is a Comprehensive Panel in Diagnosing Triple Negative Breast Cancer Brain Metastases

2021 ◽  
pp. 106689692199071
Author(s):  
Eric Statz ◽  
Julie M. Jorns
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Metastatic Tumor ◽  
Cytokeratin 7 ◽  
Breast Cancer Metastases ◽  
Her2 Breast Cancer ◽  
Cancer Metastases ◽  
Breast Cancer Brain Metastasis ◽  
The Brain

Following lung cancer, breast cancer is the second most common metastatic tumor to the brain, of which triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2+ (HER2+) breast cancer are the most common subtypes. TNBC does not have standard immunoprofiles and can be difficult to distinguish from other metastases. A tissue microarray was created from 47 patients with breast cancer metastases to the brain and 12 paired breast primaries. Of 47 breast cancer metastases, 24 were HER2+, 14 were TNBC, and 9 were luminal. Forty-five were cytokeratin 7 (CK7) positive, 36 were GATA-binding protein 3 (GATA3) positive, 7 were Sry-related HMg-Box gene 10 (SOX-10) positive, 20 were mammaglobin positive, and 19 were gross cystic disease fluid protein 15 positive. At least one of the CK7, GATA3, or SOX-10 was positive in all TNBC metastases. A panel of CK7, GATA3, and SOX-10 is complementary in the diagnosis of breast cancer brain metastasis. SOX-10 appears to be a specific but not particularly sensitive marker in this context.

Liver Resection for Multimodal Treatment of Breast Cancer Metastases: Identification of Prognostic Factors

2010 ◽  
Vol 17 (6) ◽  
pp. 1546-1554 ◽  
Author(s):  
Katrin Hoffmann ◽  
Clemens Franz ◽  
Ulf Hinz ◽  
Peter Schirmacher ◽  
Christian Herfarth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Liver Resection ◽  
Multimodal Treatment ◽  
Breast Cancer Metastases ◽  
Cancer Metastases

scholarly journals βIII-Tubulin Regulates Breast Cancer Metastases to the Brain

2015 ◽  
Vol 14 (5) ◽  
pp. 1152-1161 ◽  
Author(s):  
Deepak Kanojia ◽  
Ramin A. Morshed ◽  
Lingjiao Zhang ◽  
Jason M. Miska ◽  
Jian Qiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
The Brain

scholarly journals PO101 PROGNOSTIC FACTORS AFTER GAMMA KNIFE RADIOSURGERY IN BREAST CANCER PATIENTS WITH BRAIN METASTASES

The Breast ◽  
2015 ◽  
Vol 24 ◽  
pp. S56
Author(s):  
Shoko Hayama ◽  
Osamu Nagano ◽  
Naohito Yamamoto ◽  
Takeshi Nagashima ◽  
Rikiya Nakamura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Brain Metastases ◽  
Cancer Patients ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Breast Cancer Patients

scholarly journals CMET-19. THE ROLE OF BRAIN SPECIFIC FATTY ACID BINDING PROTEIN 7 IN BREAST CANCER METASTASES TO THE BRAIN

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi43-vi43
Author(s):  
Alex Cordero ◽  
Deepak Kanojia ◽  
Wojciech K Panek ◽  
Annie Xiao ◽  
Meijing Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Fatty Acid Binding ◽  
Specific Fatty Acid ◽  
Breast Cancer Metastases ◽  
Acid Binding Protein ◽  
Cancer Metastases ◽  
The Brain

scholarly journals BSCI-05. HOW MICROGLIA, BRAIN RESIDENT MYELOID CELLS, RESPOND TO BREAST CANCER METASTASIS INTO THE BRAIN?

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i2-i2
Author(s):  
Kamil Wojnicki ◽  
Agata Kochalska ◽  
Anna Gieryng ◽  
Tomasz Czernicki ◽  
Ewa Matyja ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Triple Negative ◽  
Metastatic Cancer ◽  
Human Breast ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
The Brain ◽  
Metastatic Cancer Cells

Abstract Brain metastasis from different cancers, including lung, breast, melanoma, colorectal or renal cell carcinoma is relatively common and its frequency increases with a prolonged survival of cancer patients. New anti-cancer therapies frequently fail to reduce metastatic burden. While the important role of tumor-associated macrophages as pro-tumorigenic cells facilitating tissue remodeling, invasion and metastasis is well documented, much less is known about the immune microenvironment of brain metastases and potential mechanisms that mediate interactions of cancer cells with brain immune cells - microglia. Triple-negative breast cancer metastases to the brain were discovered in 46% of patients. We evaluated the abundance and morphology of microglia on sections from breast cancer metastases using immunohistochemistry. We found that microglia cells are activated, surround the breast tumor cells and do not infiltrate the solid tumor. Searching for a potential attractant of microglia, we determined osteopontin levels in six human breast cancer cell lines and found upregulation of osteopontin in transformed cells, with the highest level in the triple-negative MDA-MB-231 cells. MDA-MB-231 cells activated primary murine microglia cultures when co-cultured. Invasion of MDA-MB-231 cells in co-cultures with murine immortalized BV2 microglial cells and human SV40 immortalized microglia was increased, as demonstrated using Matrigel Invasion Assay. Using immunofluorescence we detected osteopontin in cancer cells in human breast cancer metastases. Moreover, we found that minocycline, a clinically used antibiotic, reduces the osteopontin production in human breast cancer cells and the most sensitive cells were MDA-MB-231 cells. Our study shows that metastatic cancer cells may employ microglia to facilitate extravasation and colonization of brain parenchyma. We postulate that osteopontin mediates interactions between microglia and metastatic cancer cells and minocycline may interfere with those interactions. Funding: TEAM TECH CORE FACILITY FNP: Development of comprehensive diagnostics and personalized therapy in neuro-oncology

scholarly journals Pretreatment clinical prognostic factors for brain metastases from breast cancer treated with Gamma Knife radiosurgery

2016 ◽  
Vol 7 (36) ◽  
pp. 830 ◽  
Author(s):  
ChristopherM Lee ◽  
AndrewT Roehrig ◽  
EthanA Ferrel ◽  
DevonA Benincosa ◽  
AlexanderR MacKay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Brain Metastases ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery

Biologic pathways associated with breast cancer metastases to the brain.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 11038-11038
Author(s):  
Vinay Varadan ◽  
Aditi Palkar ◽  
Kristy L. S. Miskimen ◽  
Nicole Olivia Williams ◽  
Matthew Morton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Metastases ◽  
Cancer Metastases ◽  
The Brain
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