scholarly journals Tumor Lysis Syndrome: A Rare Complication of Chemotherapy for Metastatic Breast Cancer

Cureus ◽  
2019 ◽  
Author(s):  
Hafiz M Aslam ◽  
Cassandra Zhi ◽  
Sara L Wallach
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Rare Complication ◽  
Tumor Lysis Syndrome ◽  
Metastatic Breast ◽  
Tumor Lysis

scholarly journals Tumor lysis Syndrome in a Patient with Metastatic Breast Cancer Treated with Alpelisib

2021 ◽  
Vol 15 ◽  
pp. 117822342110374
Author(s):  
Caitlin Handy ◽  
Robert Wesolowski ◽  
Michelle Gillespie ◽  
Michael Lause ◽  
Sagar Sardesai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Hormone Receptor ◽  
Tumor Lysis Syndrome ◽  
Metastatic Breast ◽  
Gene Encoding ◽  
Tumor Lysis ◽  
Hormone Receptor Positive ◽  
Cancer Tumor ◽  
Life Threatening

Purpose: Tumor lysis syndrome (TLS) is a rare but life-threatening phenomenon that occurs mainly in patients with aggressive hematologic or highly chemotherapy sensitive solid tumors such as high-grade neuroendocrine carcinoma or testicular cancer. Tumor lysis syndrome is exceedingly rare in hormone receptor-positive, HER2-negative breast cancer. Furthermore, TLS following treatment with alpelisib, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor used to treat PIK3CA-mutated (gene encoding p110α subunit of PI3K), hormone receptor positive advanced breast cancer, has never been described in patients with nonhematologic malignancies. Methods: In the following case, we present a patient with hormone receptor-positive, HER2-negative, PIK3CA-mutated metastatic breast cancer who developed TLS 12 days after starting fulvestrant and alpelisib. Results: Patient was promptly treated with improvement in her renal function to baseline without requiring renal replacement therapy. Alpelisib was resumed at a reduced dose with no further complications. Conclusion: Through this case, we discuss the potential complications of TLS and the importance of prompt recognition and treatment.

scholarly journals Tumor lysis syndrome following hemi-body irradiation for metastatic breast cancer

2000 ◽  
Vol 11 (10) ◽  
pp. 1349-1352 ◽  
Author(s):  
A.Y. Rostom ◽  
G. El-Hussainy ◽  
A. Kandil ◽  
A. Allam
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tumor Lysis Syndrome ◽  
Metastatic Breast ◽  
Tumor Lysis
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