scholarly journals Spontaneous Tumor Lysis Syndrome as Presenting Sign of Metastatic Prostate Cancer

Cureus ◽  
2018 ◽  
Author(s):  
Amy McGhee-Jez ◽  
Vivek Batra ◽  
Tara Sunder ◽  
Sanaa Rizk
Keyword(s):  
Prostate Cancer ◽  
Metastatic Prostate Cancer ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic, Androgen-independent Prostate Cancer

2007 ◽  
Vol 100 (9) ◽  
pp. 916-917 ◽  
Author(s):  
Cheng-Jui Lin ◽  
Ruey-Kuen Hsieh ◽  
Ken-Hong Lim ◽  
Han-Hsiang Chen ◽  
Yi-Chou Cheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome ◽  
Androgen Independent

scholarly journals Spontaneous Tumor Lysis Syndrome in Prostate Cancer

Cureus ◽  
2021 ◽  
Author(s):  
João Pina Cabral ◽  
Joana Coelho ◽  
Jorge Fortuna ◽  
Adriano Rodrigues
Keyword(s):  
Prostate Cancer ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

Spontaneous clinical tumor lysis syndrome in solid renal tumor: first case report in non-metastatic renal carcinoma

2020 ◽  
Vol 4 (3) ◽  
pp. 124-127
Author(s):  
Bruno Nogueira Cesar ◽  
Nilo Eduardo Delboni Nunes ◽  
Maria Amelia Aguiar Hazin ◽  
Renato Demarchi Foresto ◽  
Gianna Mastroianni Kirsztajn ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
First Case ◽  
Spontaneous Tumor Lysis Syndrome ◽  
Hematological Tumors

Spontaneous tumor lysis syndrome is a rare emergency in onco-nephrology that results from extensive cancer cell lysis independent of antitumoral therapy. It is common among hematological tumors and can be rarely seen with solid tumors. In medical literature, there is only one case report with spontaneous tumor lysis syndrome in renal cell carcinoma and it was associated with metastases. To the best of our knowledge, this is the first report of spontaneous tumor lysis syndrome in non-metastatic renal cell carcinoma.

scholarly journals A Case of Spontaneous Tumor Lysis Syndrome in Malignant Melanoma

2016 ◽  
Vol 7 (2-3) ◽  
pp. 40-44 ◽  
Author(s):  
Nobumichi Takeuchi ◽  
Shun Miyazawa ◽  
Zentaro Ohno ◽  
Sonomi Yoshida ◽  
Tetsu Tsukamoto ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Spontaneous Tumor Lysis Syndrome

scholarly journals Spontaneous Tumor Lysis Syndrome in Blastoid-Variant Mantle Cell Lymphoma: Considerations for the General Internist

2020 ◽  
Vol 8 ◽  
pp. 232470962094470 ◽  
Author(s):  
Vishal Patel ◽  
Robert Case
Keyword(s):  
Uric Acid ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Tumor Lysis Syndrome ◽  
General Internist ◽  
Tumor Lysis ◽  
Spontaneous Tumor ◽  
Mantle Cell ◽  
Spontaneous Tumor Lysis Syndrome

Spontaneous tumor lysis syndrome (SPTLS) is a rare phenomenon that can manifest in rapidly proliferating hematological malignancies and solid tumors prior to initiating cytotoxic therapy. We encountered a patient who originally presented with diffuse lymphadenopathy, abdominal distention, and dyspnea, who had laboratory abnormalities suggestive of SPTLS. His peripheral flow cytometry and lymph node biopsy revealed blastoid-variant mantle cell lymphoma. Prior to initiating chemotherapy, acute kidney injury (AKI) and uric acid had improved with intravenous fluids and the initiation of allopurinol. However, after beginning chemotherapy, the patient developed a second AKI concerning for tumor lysis syndrome (TLS). He went on to have renal recovery and did not require renal replacement therapy. With the exception of case reports, there is limited evidence to guide general medicine clinicians who encounter cases of SPTLS. Expert-based guidelines are available to guide use of rasburicase, an uricase enzyme, before initiation of chemotherapy for certain malignancies when risk for TLS is considered high. Despite these guidelines, the role of rasburicase in preventing AKI remains controversial after inconclusive results in a meta-analysis. The causative relationship between uric acid and AKI in TLS is based on a mechanism of tubular obstruction. There are also mechanisms by which uric acid may cause AKI without tubular obstruction related to acute hyperuricemic nephropathy. Further characterization of the role of uric acid in causing AKI in patients without tubular obstruction may identify new mechanisms of injury and offer insight into new treatment strategies.

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