scholarly journals Synchronous Oligometastatic Non-Small Cell Lung Cancer and Isolated Renal Cell Carcinoma: A Case Report and Literature Review

Cureus ◽  
2015 ◽  
Author(s):  
Timothy K Nguyen ◽  
Alexander V Louie
Keyword(s):  
Lung Cancer ◽  
Renal Cell Carcinoma ◽  
Case Report ◽  
Literature Review ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Cell Lung Cancer ◽  
Renal Cell ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Predictors of immunotherapy-induced immune-related adverse events

2018 ◽  
Vol 25 (5) ◽  
Author(s):  
A. Kartolo ◽  
J. Sattar ◽  
V. Sahai ◽  
T. Baetz ◽  
J. M. Lakoff
Keyword(s):  
Lung Cancer ◽  
Renal Cell Carcinoma ◽  
Adverse Events ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Cell Lung Cancer ◽  
Renal Cell ◽  
Small Cell ◽  
Small Cell Lung ◽  
Goodness Of Fit Test

Purpose We aimed to elucidate predictive factors for the development of immune-related adverse events (iraes) in patients receiving immunotherapies for the management of advanced solid cancers.Methods This retrospective study involved all patients with histologically confirmed metastatic or inoperable melanoma, non-small-cell lung cancer, or renal cell carcinoma receiving immunotherapy at the Cancer Centre of Southeastern Ontario. The type and severity of iraes, as well as potential protective and exacerbating factors, were collected from patient charts.ResultsThe study included 78 patients receiving ipilimumab (32%), nivolumab (33%), or pembrolizumab (35%). Melanoma, non-small-cell lung cancer, and renal cell carcinoma accounted for 70%, 22%, and 8% of the cancers in the study population. In 41 patients (53%) iraes developed, with multiple iraes developing in 12 patients (15%). In most patients (70%), the iraes were of severity grade 1 or 2. Female sex [adjusted odds ratio (oradj): 0.094; 95% confidence interval (ci): 0.021 to 0.415; p = 0.002] and corticosteroid use before immunotherapy (oradj: 0.143; 95% ci: 0.036 to 0.562; p = 0.005) were found to be associated with a protective effect against iraes. In contrast, a history of autoimmune disease (oradj: 9.55; 95% ci: 1.34 to 68.22; p = 0.025), use of ctla-4 inhibitors (oradj: 6.25; 95% ci: 1.61 to 24.25; p = 0.008), and poor kidney function of grade 3 or greater (oradj: 10.66; 95% ci: 2.41 to 47.12; p = 0.025) were associated with a higher risk of developing iraes. A Hosmer–Lemeshow goodness-of-fit test demonstrated that the logistic regression model was effective at predicting the development of iraes (chi-square: 1.596; df = 7; p = 0.979).Conclusions Our study highlights several factors that affect the development of iraes in patients receiving immunotherapy. Although future studies are needed to validate the resulting model, findings from the study can help to guide risk stratification, monitoring, and management of iraes in patients given immunotherapy for advanced cancer.

scholarly journals Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non–Small Cell Lung Cancer Treated With Nivolumab

JAMA Oncology ◽  
2019 ◽  
Vol 5 (10) ◽  
pp. 1411 ◽  
Author(s):  
Suzanne L. Topalian ◽  
F. Stephen Hodi ◽  
Julie R. Brahmer ◽  
Scott N. Gettinger ◽  
David C. Smith ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Renal Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Cell Lung Cancer ◽  
Renal Cell ◽  
Advanced Melanoma ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Synchronous Pulmonary Renal Cell Carcinoma Metastases and Primary Non-small Cell Lung Cancer

2010 ◽  
Vol 5 (1) ◽  
pp. 140-141 ◽  
Author(s):  
David T. Cooke ◽  
Dennis J. Zheng ◽  
Karen A. Peterson ◽  
Royce F. Calhoun
Keyword(s):  
Lung Cancer ◽  
Renal Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Cell Lung Cancer ◽  
Renal Cell ◽  
Small Cell ◽  
Small Cell Lung

Peripheral changes in immune cell populations and soluble mediators after anti-PD-1 therapy in non-small cell lung cancer and renal cell carcinoma patients

2019 ◽  
Vol 68 (10) ◽  
pp. 1585-1596 ◽  
Author(s):  
Estefanía Paula Juliá ◽  
Pablo Mandó ◽  
Manglio Miguel Rizzo ◽  
Gerardo Rubén Cueto ◽  
Florencia Tsou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Renal Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Cell Lung Cancer ◽  
Renal Cell ◽  
Immune Cell ◽  
Small Cell ◽  
Cell Populations ◽  
Small Cell Lung

Myasthenia gravis induced by nivolumab in patients with non-small-cell lung cancer: a case report and literature review

Immunotherapy ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 701-707 ◽  
Author(s):  
Yoshikazu Hasegawa ◽  
Shigeru Kawai ◽  
Takayo Ota ◽  
Hiroshi Tsukuda ◽  
Masahiro Fukuoka
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Literature Review ◽  
Myasthenia Gravis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung
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