scholarly journals Drug-induced Angioedema: A Rare Side Effect of Rosuvastatin

Cureus ◽  
2018 ◽  
Author(s):  
Amir Shahbaz ◽  
Rupak Mahendhar ◽  
Mina Fransawy alkomos ◽  
Paria Zarghamravanbakhsh ◽  
Issac Sachmechi
Keyword(s):  
Side Effect ◽  
Drug Induced ◽  
Rare Side Effect

scholarly journals Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Dong Li ◽  
Aixin Li ◽  
Hairui Zhou ◽  
Xi Wang ◽  
Peng Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Side Effect ◽  
Chemical Structure ◽  
Safety Evaluation ◽  
Underlying Mechanism ◽  
Mapk Signaling ◽  
Drug Induced ◽  
Drug List ◽  
Rare Side Effect

Drug-induced myopathy (DIM) is a rare side effect; however, the consequence could be fatal. There are few reports to systematically assess the underlying mechanism of DIM. In this study, we curated the comprehensive DIM drug list based on structured labeling products (SPLs) and carried out the analysis based on chemical structure space, drug protein interaction, side effect space, and transcriptomic profiling space. Some key features are enriched from each of analysis. Specifically, the similarity of DIM drugs is more significant than random chance, which shows that the chemical structure could distinguish the DIM-positive drugs from negatives. The cytochrome P450 (CYP) was identified to be shared by DIM drugs, which indicated the important role of metabolism in DIM. Three pathways including pathways in cancer, MAPK signaling pathway, and GnRH signaling pathway enriched based on transcriptomic analysis may explain the underlying mechanism of DIM. Although the DIM is the current focus of the study, the proposed approaches could be applied to other toxicity assessments and facilitate the safety evaluation.

Ejaculatory Dysfunction Produced by Clozapine. Three Case Reports and Review of Pathophysiological Mechanisms

1993 ◽  
Vol 60 (4) ◽  
pp. 354-356
Author(s):  
Y. Talmon ◽  
M. Guy ◽  
S. Eisenkraft ◽  
N. Guy
Keyword(s):  
Drug Therapy ◽  
Side Effect ◽  
Case Reports ◽  
Retrograde Ejaculation ◽  
Anti Psychotic ◽  
Drug Induced ◽  
Pathophysiological Mechanisms ◽  
Rare Side Effect ◽  
Schizophrenic Patients ◽  
Ejaculatory Dysfunction

Three chronic paranoid schizophrenic patients were treated with clozapine, a new anti-psychotic agent. Retrograde ejaculation developed as a side-effect. Stopping the drug therapy or reducing the dosage caused the side-effect to disappear. Re-challenge caused the return of the side-effect. We discuss this rare side-effect to clozapine, and the pathophysiological mechanisms of ejaculation disturbances, with emphasis on those that are drug-induced.

scholarly journals Drug-induced Angioedema: A Rare Side Effect of Mirabegron

2019 ◽  
Vol 2019 ◽  
Author(s):  
Harley Davis ◽  
◽  
Troy Wallace, MD ◽  
Christine Gilkerson, MD ◽  
Elizabeth Saunders, MD ◽  
...  
Keyword(s):  
Side Effect ◽  
Drug Induced ◽  
Rare Side Effect

scholarly journals S2793 Drug-Induced Liver Injury Secondary to Intravenous Acyclovir: A Rare Side Effect

2021 ◽  
Vol 116 (1) ◽  
pp. S1162-S1162
Author(s):  
Joel Joseph ◽  
William Green ◽  
Jacqueline Lippert ◽  
Girish Mishra
Keyword(s):  
Liver Injury ◽  
Side Effect ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Intravenous Acyclovir ◽  
Rare Side Effect

scholarly journals Why is My Skin Turning Black? A Rare Side Effect of Capecitabine

2020 ◽  
Vol 4 (3) ◽  
pp. 275
Author(s):  
Madeline Adelman ◽  
Jesse Veenstra ◽  
Ira Wollner ◽  
Joseph McGoey
Keyword(s):  
Adverse Effect ◽  
Side Effect ◽  
Metastatic Breast ◽  
Colon Adenocarcinoma ◽  
Colorectal Cancers ◽  
Separate Entity ◽  
Drug Induced ◽  
Rare Side Effect ◽  
Hand Foot Syndrome ◽  
Grading Scale

Introduction: Capecitabine is an oral chemotherapy frequently used in the treatment of metastatic breast and colorectal cancers. Drug-induced cutaneous hyperpigmentation is a rare adverse effect of capecitabine, which is almost exclusively reported with development of hand-foot syndrome (HFS). Here, we report a case of capecitabine-induced hyperpigmentation affecting the hands, feet, face, and tongue in the complete absence of HFS.Case report: An 82-year old man presented with progressive hyperpigmentation of his hands, feet, face, and tongue shortly after initiating capecitabine for treatment of colon adenocarcinoma. There was no associated erythema, edema, blistering, desquamation, tingling, or tenderness. After completion of capecitabine therapy, he endorsed 95% resolution of all hyperpigmentation.Discussion: Previous reports of capecitabine-induced hyperpigmentation have argued that it may be a sign of impending toxicity and should be a part of the HFS grading scale. Others argue that the two are separate entities, yet the mechanism is still unknown. This case supports that capecitabine can cause hyperpigmentation independent of HFS, and thus, should be evaluated as a separate entity of HFS if other symptoms are lacking.

scholarly journals Functional and anatomical characterization of a non-leaking bilateral cystoid macular edema induced by paclitaxel therapy for ovarian cancer: a case report

2019 ◽  
Author(s):  
Stephan Hoffmann ◽  
David Ganster ◽  
Patrick Sidoroff ◽  
Stefan Mennel
Keyword(s):  
Ovarian Cancer ◽  
Macular Edema ◽  
Side Effect ◽  
Cystoid Macular Edema ◽  
Vision Loss ◽  
Early Recognition ◽  
Fluorescence Angiography ◽  
Drug Induced ◽  
Rare Side Effect ◽  
Paclitaxel Treatment

Abstract Abstract: Background: Paclitaxel is a member of the taxane family used for cancer therapy. Ovarian cancer is treated with Paclitaxel in first- and in second- line therapy. Cystoid macular edema without fluorescein leakage is a rare side effect of Paclitaxel treatment. Case presentation: We report the case of a 59-year-old female with ovarian cancer treated with paclitaxel. The patient received 21 cycles of adjuvant chemotherapy and was presented with bilateral gradual vision loss due to macular edema after paclitaxel treatment. Optical coherence tomography revealed a bilateral cystoid macular edema. Fluorescence angiography demonstrated the unusual finding of non-leakage in the late phases of the angiogram. Microperimetric findings of both eyes confirmed the visual deficits. After cessation of the paclitaxel therapy, vision, OCT and microperimetric findings returned to normal. Also, color vision testing demonstrated no persistent defect after therapy cessation. Conclusion: Paclitaxel induced bilateral maculopathy is a rare side effect of chemotherapy. Cessation of the Paclitaxel drug therapy leads to complete functional and anatomical resolution of drug induced side effects. Vision, microperimetric defects, color perception as also anatomical defects detected by OCT change to normal after drug cessation. Taxane induced bilateral maculopathy is a rare disease which should be known by ophthalmologists as also oncologists. Paclitaxel therapy must be counseled to report any vision problems during the treatment period because early recognition of a rare non leaking CME can facilitate appropriate intervention to reverse visual compromise and minimize any potential long-term ophthalmologic sequelae.

scholarly journals Probable Levofloxacin-Induced Thrombocytopenia in a Patient Previously on Ciprofloxacin: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
A. Justine Landi ◽  
Robert Burkes
Keyword(s):  
Case Report ◽  
Clinical Practice ◽  
Literature Review ◽  
Side Effect ◽  
Case Reports ◽  
Common Phenomenon ◽  
Drug Induced ◽  
Algorithmic Approach ◽  
Rare Side Effect

Drug-induced thrombocytopenia is a poorly understood, yet common phenomenon widely encountered in clinical practice. We present a case of suspected levofloxacin-induced thrombocytopenia, a rare side effect of a ubiquitous antibiotic, in a patient without similar effect to ciprofloxacin. This report builds upon other isolated case reports of fluoroquinolone-induced thrombocytopenia and demonstrates our algorithmic approach to the issue as well as a literature review pertaining to fluoroquinolone-induced thrombocytopenia.

scholarly journals Drug Induced Encephalopathy in Patients with Chronic Kidney Disease: A Case Series

2018 ◽  
Vol 8 (2) ◽  
pp. 172-176
Author(s):  
Wasim Md Mohosin Ul Haque ◽  
Tabassum Samad ◽  
Muhammad Abdur Rahim ◽  
Shudhanshu Kumar Saha ◽  
Sarwar Iqbal
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Impairment ◽  
Side Effect ◽  
Case Series ◽  
Special Group ◽  
Drug Induced ◽  
Reduced Dose

Drug induced encephalopathy is an established side effect of many drugs when used in a higher dose. Though we do not encounter this side effect frequently in our day to day practice, yet with renal impairment this is not uncommon. Even with a reduced dose many of these can precipitate encephalopathy in this special group of patients. We are presenting here a series of seven such cases of drug induced encephalopathy in patients with renal impairment.Birdem Med J 2018; 8(2): 172-176

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