scholarly journals The Role of Thrombolytic Therapy for Patients with a Submassive Pulmonary Embolism

Cureus ◽  
2018 ◽  
Author(s):  
Elizabeth Murphy ◽  
Ahmed Lababidi ◽  
Renuka Reddy ◽  
Taaha Mendha ◽  
David Lebowitz
Keyword(s):  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Submassive Pulmonary Embolism

scholarly journals Thrombolytic therapy for pulmonary embolism: lessons from recent clinical trials

2015 ◽  
Vol 3 (4) ◽  
Author(s):  
Lexin Wang
Keyword(s):  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Clinical Studies ◽  
Massive Pulmonary Embolism ◽  
Common Disease ◽  
Thrombolytic Treatment ◽  
Normal Blood Pressure ◽  
Life Saving ◽  
Submassive Pulmonary Embolism

Pulmonary embolism is a common disease that is associated with significant mobility and mortality. Thrombolysis is potentially life saving when used in conjunction with anticoagulant therapy. Indications for thrombolysis for pulmonary embolism are not well defined. In patients with acute massive pulmonary embolism and hypotension, thrombolytic therapy offers some benefits in terms of mortality reduction. The use of thrombolysis in patients with stable haemodynamics has been controversial for more than two decades. Recent clinical studies have indicated that thrombolytic treatment in conjunction with heparin in patients with submassive pulmonary embolism and normal blood pressure can prevent deterioration of the disease and diminish the need for more intensive therapies during hospitalisation. The role of prehospital thrombolytic therapy for acute pulmonary embolism is unclear and further clinical studies are warranted.

scholarly journals Short-Term Mortality in Patients with Massive and Submassive Pulmonary Embolism Receiving Thrombolytic Therapy

2013 ◽  
Vol 84 (1) ◽  
pp. 62 ◽  
Author(s):  
Yun-Ju Cho ◽  
So-My Koo ◽  
Duk Won Bang ◽  
Ki-Up Kim ◽  
Soo-taek Uh ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Short Term ◽  
Submassive Pulmonary Embolism ◽  
Short Term Mortality

Do patients with submassive pulmonary embolism benefit from thrombolytic therapy?

2016 ◽  
Vol 83 (12) ◽  
pp. 923-932
Author(s):  
Ali Ataya ◽  
Jessica Cope ◽  
Abbas Shahmohammadi ◽  
Hassan Alnuaimat
Keyword(s):  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Submassive Pulmonary Embolism

Role of rheolytic thrombectomy in massive pulmonary embolism with contraindication to systemic thrombolytic therapy

2010 ◽  
Vol 5 (6) ◽  
pp. 716-721 ◽  
Author(s):  
Dabit Arzamendi ◽  
Luc Bilodeau ◽  
Reda Ibrahim ◽  
Stephane Noble ◽  
Richard Gallo ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Thrombolytic Therapy ◽  
Massive Pulmonary Embolism ◽  
Systemic Thrombolytic Therapy ◽  
Rheolytic Thrombectomy

scholarly journals Role of Interventional Radiologist in the Management of Acute Pulmonary Embolism

2020 ◽  
Vol 37 (01) ◽  
pp. 062-073
Author(s):  
William Bremer ◽  
Charles E. Ray ◽  
Ketan Y. Shah
Keyword(s):  
Pulmonary Embolism ◽  
Interventional Radiology ◽  
Vital Role ◽  
Aspiration Thrombectomy ◽  
Catheter Directed Thrombolysis ◽  
Clinical Presentations ◽  
Submassive Pulmonary Embolism ◽  
Wide Range ◽  
Short And Long Term

AbstractPulmonary embolism is a common cause of morbidity and mortality which continues to increase in overall incidence. Because it can occur with a wide range of clinical presentations, different guidelines have been developed for appropriate risk stratification of patients; interventional radiology plays a vital role in the management of both massive and submassive pulmonary embolism. Catheter-directed therapy, including mechanical and aspiration thrombectomy, standard catheter-directed thrombolysis, and ultrasound-accelerated thrombolysis, has many benefits, including lower thrombolytic doses and intraclot administration of thrombolytic therapy. While the role of catheter-directed therapy is still being developed, four important prospective studies have demonstrated its safety and efficacy. Additional studies comparing short- and long-term clinical outcomes in patients treated with catheter-directed therapy versus anticoagulation are the next step in understanding its role within the management of submassive pulmonary embolism. Furthermore, multidisciplinary pulmonary embolism response teams, in which interventional radiology plays a crucial role, are becoming essential to appropriately managing pulmonary embolism patients, including selection of those who may benefit from catheter-directed therapy.

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