scholarly journals The Current Trend of the Translational Research Paradigm

Cureus ◽  
2018 ◽  
Author(s):  
Paul J Choi ◽  
R. Shane Tubbs ◽  
Rod J Oskouian
Keyword(s):  
Translational Research ◽  
Current Trend ◽  
Research Paradigm

Toward a Translational Research Paradigm for Addiction

PsycCRITIQUES ◽  
2007 ◽  
Vol 52 (36) ◽  
Author(s):  
Tony Cellucci ◽  
Leslie Devaud
Keyword(s):  
Translational Research ◽  
Research Paradigm

‘A local habitation and a name’: how narrative evidence-based medicine transforms the translational research paradigm

2008 ◽  
Vol 14 (5) ◽  
pp. 732-741 ◽  
Author(s):  
Rishi K. Goyal ◽  
Rita Charon ◽  
Helen-Maria Lekas ◽  
Mindy T. Fullilove ◽  
Michael J. Devlin ◽  
...  
Keyword(s):  
Translational Research ◽  
Evidence Based Medicine ◽  
Evidence Based ◽  
Research Paradigm ◽  
Based Medicine

Nonsurgical Therapies for Hepatocellular and Cholangiocellular Carcinoma

Swiss Surgery ◽  
1999 ◽  
Vol 5 (3) ◽  
pp. 116-121 ◽  
Author(s):  
Schmassmann
Keyword(s):  
Current Trend ◽  
Percutaneous Ethanol Injection ◽  
Cholangiocellular Carcinoma ◽  
Multidisciplinary Therapy ◽  
Term Survival ◽  
Ethanol Injection ◽  
First Choice ◽  
Tumor Stages ◽  
Choice Of Treatment ◽  
Advanced Stages

Surgical resection is the first choice of treatment for patients with hepatocellular (HCC) and cholangiocellular carcinomas. Prolongation of survival is, however, the only realistic goal for most patients, which can be often achieved by nonsurgical therapies. Inoperable patients with large or multiple HCCs are usually treated with transarterial chemoembolization (TACE) with lipiodol in combination with a chemotherapeutic drug and gelfoam. Three-year survival depends on the stage of the disease and is about 20%. Patients with earlier tumor stages (one or two tumor nodules less than 3cm in size) are suitable for treatment with percutaneous ethanol injection (PEI) alone or in combination with TACE. Several studies have shown that in these early stages, the 3-year survival rate is approximately 55%-70% in the actively treated patients which is significantly higher than in untreated patients. In advanced stages of the disease, TACE and PEI have no effect on survival and should not be performed. Some of these patients have been successfully treated with octreotide. Patients with inoperable cholangiocellular carcinoma are treated by endoscopic or percutaneous stent placement. If stenting does not achieve adequate biliary drainage, multidisciplinary therapy including internal / external radiotherapy or photodynamic therapy should be considered in patients with potential long-term survival. In conclusion, nonresectional therapies play an essential role in the therapy of inoperable hepato- and cholangiocellular carcinomas as they lead to satisfactory survival. Multidisciplinary therapy appears to be the current trend of management.

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