scholarly journals A Case Presentation Based on Incidental Diagnosis of Atrial Myxoma in a Patient Presenting With Atrial Fibrillation and Suspected Carney Complex

Cureus ◽  
2022 ◽  
Author(s):  
Zahid Khan ◽  
Umesh Kumar Pabani ◽  
Animesh Gupta ◽  
Sunaina Lohano ◽  
Gideon Mlawa
Keyword(s):  
Atrial Fibrillation ◽  
Carney Complex ◽  
Atrial Myxoma ◽  
Case Presentation ◽  
Incidental Diagnosis

scholarly journals Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Ashley Roque ◽  
Tara Kimbrough ◽  
Christopher Traner ◽  
Joachim M. Baehring ◽  
Anita Huttner ◽  
...  
Keyword(s):  
Vascular Wall ◽  
Carney Complex ◽  
Brain Parenchyma ◽  
Atrial Myxoma ◽  
Cardiac Complications ◽  
Case Presentation ◽  
Whole Exome ◽  
Cardiac Myxomas ◽  
Sporadic Tumors ◽  
Dominant Condition

Abstract Background Atrial myxomas are generally considered benign neoplasms. The majority of tumors are sporadic and less than 10% are associated with an autosomal dominant condition known as the Carney complex, which is most often caused by germline mutation in the gene PRKAR1A. Whether this gene plays a role in the development of sporadic myxomas has been an area of debate, although recent studies have suggested that some fraction of sporadic tumors also carry mutations in PRKARIA. Extra-cardiac complications of atrial myxoma include dissemination of tumor to the brain; however, the dissemination of viable invasive tumor cells is exceedingly rare. Case presentation We present here a 48-year-old white woman who developed multiple intracranial hemorrhagic lesions secondary to tumor embolism that progressed to ‘false’ aneurysm formation and invasion through the vascular wall into brain parenchyma 7 months after resection of an atrial myxoma. Whole exome sequencing of her tumor revealed multiple mutations in PRKAR1A not found in her germline deoxyribonucleic acid (DNA), suggesting that the myxoma in this patient was sporadic. Conclusions Our patient illustrates that mutations in PRKAR1A may be found in sporadic lesions. Whether the presence of this mutation affects the clinical behavior of sporadic tumors and increases risk for metastasis is not clear. Regardless, the protein kinase A pathway which is regulated by PRKAR1A represents a possible target for treatment in patients with metastatic cardiac myxomas harboring mutations in the PRKARIA gene.

CLINICAL CHALLENGES FOR ANESTHESIOLOGIST FACING PATIENT WITH ACROMEGALY. CASE REPORT

2020 ◽  
Vol 30 (3) ◽  
pp. 56-59
Author(s):  
Jūratė Gudaitytė ◽  
Justina Jermolajevaitė ◽  
Martynas Judickas
Keyword(s):  
Atrial Fibrillation ◽  
Case Report ◽  
General Population ◽  
Metabolic Disorders ◽  
Upper Airway ◽  
Cardiovascular Complications ◽  
Case Presentation ◽  
Increased Risk ◽  
Fluid Regulation ◽  
Class Iv

Background and objectives: Acromegaly is endocri­nal disorder which results in changes involving ge­neral appearance as well as upper airway abnorma­lities, cardiovascular and metabolic disorders which can aggravate the anesthesia and can lead to compli­cations. We aim to discuss the challenges for anesthe­siologist that occurs facing patient with acromegaly and are necessary to investigate before performing any kind of intervention. Case Presentation: 79 years old male patient presen­ted the hospital with recently diagnosed acromegaly for rectal prolapse surgery. From anamnesis he had NYHAIII with cardiomyopathy, atrial fibrillation and arterial hypertension, also multiple old compressive fractures Th10 – L5. He was graded with Mallam­pati score IV and ASA class IV. The complemen­tary examinations were made to assess the possible complications. In induction of general anesthesia the intubation was performed using fibro- bronchoscope and anesthesia went without complications except hypotension which was managed. After surgery the patient was leaded to the postoperative room for furt­her monitoring. Discussion and Conclusion: Acromegalic patients have an increased risk of difficulty during anesthe­sia compared to general population due to difficult intubation, cardiovascular complications , OSA , alte­ration in intraoperative glucose intolerance and fluid regulation. Therefore profound investigation and as­sessment are necessary to predict and prepare for possible difficulties in the surgery room.

scholarly journals Early recurrent left atrial myxoma in a teenager with de novo mutation of Carney complex

2011 ◽  
Vol 17 (2) ◽  
pp. 108 ◽  
Author(s):  
MilaS Stajevic ◽  
VladimirD Kuburovic ◽  
VladislavA Vukomanovic ◽  
SlavisaM Djuricic
Keyword(s):  
Left Atrial ◽  
De Novo ◽  
Carney Complex ◽  
Atrial Myxoma ◽  
De Novo Mutation ◽  
Left Atrial Myxoma

scholarly journals Recurrent left atrial myxoma in Carney complex

Medicine ◽  
2018 ◽  
Vol 97 (12) ◽  
pp. e0247 ◽  
Author(s):  
Liaoyuan Wang ◽  
Qing Wang ◽  
Yue Zhou ◽  
Qian Xue ◽  
Xiao Sun ◽  
...  
Keyword(s):  
Left Atrial ◽  
Carney Complex ◽  
Atrial Myxoma ◽  
Left Atrial Myxoma

68-year-old woman with paroxysmal atrial fibrillation

Heart ◽  
2018 ◽  
pp. heartjnl-2018-314143
Author(s):  
Eftihia Sbarouni ◽  
Nektarios Kogerakis ◽  
George Stavridis
Keyword(s):  
Atrial Fibrillation ◽  
Paroxysmal Atrial Fibrillation ◽  
Mitral Stenosis ◽  
Left Atrial ◽  
Septal Defect ◽  
Left Atrial Appendage ◽  
Atrial Myxoma ◽  
List Type ◽  
Left Atrial Myxoma ◽  
Left Atrial Appendage Aneurysm

QuestionWhat is the most likely diagnosis?Mitral stenosis.Pericardial cyst.Left atrial appendage aneurysm.Left atrial myxoma.Atrial septal defect.

Left atrial myxoma in a patient with atrial fibrillation following ischemic stroke – Case report

2016 ◽  
Vol 23 (2) ◽  
pp. 147-150
Author(s):  
Elżbieta Malarkiewicz ◽  
Sonia J. Konsek ◽  
Paulina A. Dziamałek ◽  
Grzegorz Wasilewski
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Case Report ◽  
Left Atrial ◽  
Atrial Myxoma ◽  
Left Atrial Myxoma ◽  
Stroke Case

Evidence for Genetic Heterogeneity of the Carney Complex (Familial Atrial Myxoma Syndromes)

1998 ◽  
Vol 106 (2) ◽  
pp. 173-176 ◽  
Author(s):  
Jeff Milunsky ◽  
Xin-Li Huang ◽  
Clinton T Baldwin ◽  
Michel G Farah ◽  
Aubrey Milunsky
Keyword(s):  
Genetic Heterogeneity ◽  
Carney Complex ◽  
Atrial Myxoma
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