scholarly journals Primary Antibody Deficiencies With Pulmonary Complications: A Single-Center Experience

Cureus ◽  
2022 ◽  
Author(s):  
Güzin Özden ◽  
Pelin Pınar Deniz ◽  
Pelin Duru Cetinkaya
Keyword(s):  
Pulmonary Complications ◽  
Primary Antibody ◽  
Single Center ◽  
Single Center Experience ◽  
Primary Antibody Deficiencies

scholarly journals A single center 14 years study of infectious complications leading to hospitalization of patients with primary antibody deficiencies

2010 ◽  
Vol 14 (4) ◽  
pp. 351-355 ◽  
Author(s):  
Setareh Mamishi ◽  
Aiden Nasiri Eghbali ◽  
Nima Rezaei ◽  
Hassan Abolhassani ◽  
Nima Parvaneh ◽  
...  
Keyword(s):  
Infectious Complications ◽  
Primary Antibody ◽  
Single Center ◽  
Primary Antibody Deficiencies

scholarly journals Multiple Breath Wash-out for early assessment of pulmonary complications in patients with Primary Antibody Deficiencies: an observational study in pediatric age

2021 ◽  
Author(s):  
Teresa Secchi ◽  
Lucia Augusta Baselli ◽  
Maria Chiara Russo ◽  
Irene Borzani ◽  
Federica Carta ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Pulmonary Function Tests ◽  
Pulmonary Complications ◽  
Lung Damage ◽  
Primary Antibody ◽  
Early Assessment ◽  
High Resolution Computed Tomography ◽  
Specific Test ◽  
Ventilation Inhomogeneity ◽  
Primary Antibody Deficiencies

Abstract Purpose. In Primary Antibody Deficiencies (PADs), pulmonary complications are the main cause of morbidity, despite immunoglobulin substitutive therapy, antibiotic treatment of exacerbations and respiratory physiotherapy. Current recommendations for surveillance of PADs respiratory complications include the annual assessment of spirometry and the execution of chest High Resolution Computed Tomography (HRCT) every four years.This study aims to evaluate the effectiveness of Lung Clearance Index (LCI) as early marker of lung damage in patients with PADs. LCI is measured by Multiple Breath Wash-out, a non-invasive and highly specific test widely used in Cystic Fibrosis patients.Methods. Pediatric patients with PADs (n=17, 10, M, 7, F, age range 5-15 years) underwent baseline assessment of lung involvement with chest HRCT, Spirometry and Multiple Breath nitrogen Wash-out. Among them, 13 patients were followed up to repeat HRCT after four years, while performing Pulmonary Function Tests annually. Their baseline and control LCI and FEV1 values were compared, taking HRCT as gold standard, using logistic regression analysis.Results. LCI (OR 2.43 at baseline, OR 14.95 at control) has a stronger discriminating power between altered and normal HRCT rather than FEV1 (OR 0.82 at baseline, OR 1.91 at control).Conclusion. Within the context of a limited sample size, LCI seems to be more predictive of HRCT alterations than FEV1 and more sensitive than HRCT in detecting ventilation inhomogeneity, in absence of bronchiectasis. A study of a larger cohort of pediatric patients followed longitudinally in adulthood is needed to challenge these findings.

scholarly journals Post COVID-19 pulmonary complications; a single center experience

2021 ◽  
pp. 103052
Author(s):  
Okba F. Ahmed ◽  
Fahmi H. kakamad ◽  
Bnar J. Amin ◽  
Berwn A. Abdullah ◽  
Marwan N. Hassan ◽  
...  
Keyword(s):  
Pulmonary Complications ◽  
Single Center ◽  
Single Center Experience

scholarly journals A single center 14 years study of infectious complications leading to hospitalization of patients with primary antibody deficiencies

2010 ◽  
Vol 14 (4) ◽  
pp. 351-355
Author(s):  
Setareh Mamishi ◽  
Aiden Nasiri Eghbali ◽  
Nima Rezaei ◽  
Hassan Abolhassani ◽  
Nima Parvaneh ◽  
...  
Keyword(s):  
Infectious Complications ◽  
Primary Antibody ◽  
Single Center ◽  
Primary Antibody Deficiencies

Pulmonary Complications in Survivors of Childhood Hematological Malignancies: Single-Center Experience

2011 ◽  
Vol 28 (5) ◽  
pp. 403-417 ◽  
Author(s):  
Azza Abdel Gawad Tantawy ◽  
Nancy Elbarbary ◽  
Asmaa Ahmed ◽  
Nancy Abdraoaf Mohamed ◽  
Sahar Ezz-Elarab
Keyword(s):  
Hematological Malignancies ◽  
Pulmonary Complications ◽  
Single Center ◽  
Single Center Experience

scholarly journals The broad spectrum of lung diseases in primary antibody deficiencies

2018 ◽  
Vol 27 (149) ◽  
pp. 180019 ◽  
Author(s):  
Francesco Cinetto ◽  
Riccardo Scarpa ◽  
Marcello Rattazzi ◽  
Carlo Agostini
Keyword(s):  
Broad Spectrum ◽  
Lung Diseases ◽  
Adaptive Immune Response ◽  
Interstitial Lung Diseases ◽  
Pulmonary Complications ◽  
Primary Antibody ◽  
Primary Antibody Deficiencies ◽  
Pulmonary Manifestations ◽  
Relevant Role ◽  
Immune Defects

Human primary immunodeficiency diseases (PIDs) represent a heterogeneous group of more than 350 disorders. They are rare diseases, but their global incidence is more relevant than generally thought. The underlying defect may involve different branches of the innate and/or adaptive immune response. Thus, the clinical picture may range from severe phenotypes characterised by a broad spectrum of infections to milder infectious phenotypes due to more selective (and frequent) immune defects. Moreover, infections may not be the main clinical features in some PIDs that might present with autoimmunity, auto-inflammation and/or cancer. Primary antibody deficiencies (PADs) represent a small percentage of the known PIDs but they are the most frequently diagnosed, particularly in adulthood. Common variable immunodeficiency (CVID) is the most prevalent symptomatic PAD.PAD patients share a significant susceptibility to respiratory diseases that represent a relevant cause of morbidity and mortality. Pulmonary complications include acute and chronic infection-related diseases, such as pneumonia and bronchiectasis. They also include immune-mediated interstitial lung diseases, such as granulomatous-lymphocytic interstitial lung disease (GLILD) and cancer. Herein we will discuss the main pulmonary manifestations of PADs, the associated functional and imaging findings, and the relevant role of pulmonologists and chest radiologists in diagnosis and surveillance.

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