scholarly journals Ruxolitinib Reduces Oxidative Stress in Patients With Primary Myelofibrosis: A Multicenter Study

Cureus ◽  
2022 ◽  
Author(s):  
Mahmut B Koyuncu ◽  
Mustafa Ilgan ◽  
Hakan Basir ◽  
Anil Tombak ◽  
Mehmet Ali Ucar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multicenter Study ◽  
Primary Myelofibrosis

scholarly journals A multicenter study to evaluate oxidative stress by oxidation-reduction potential, a reliable and reproducible method

Andrology ◽  
2017 ◽  
Vol 5 (5) ◽  
pp. 939-945 ◽  
Author(s):  
A. Agarwal ◽  
M. Arafa ◽  
R. Chandrakumar ◽  
A. Majzoub ◽  
S. AlSaid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multicenter Study ◽  
Reduction Potential ◽  
Oxidation Reduction ◽  
Oxidation Reduction Potential ◽  
Reproducible Method

scholarly journals Role of TGF ‐β1/miR‐382‐5p/ SOD 2 axis in the induction of oxidative stress in CD 34+ cells from primary myelofibrosis

2018 ◽  
Vol 12 (12) ◽  
pp. 2102-2123 ◽  
Author(s):  
Chiara Rossi ◽  
Roberta Zini ◽  
Sebastiano Rontauroli ◽  
Samantha Ruberti ◽  
Zelia Prudente ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Primary Myelofibrosis ◽  
Cd 34 ◽  
Tgf Β1

Ineffective Thrombopoiesis

1990 ◽  
Vol 48 (3) ◽  
pp. 266-267
Author(s):  
JM Radley ◽  
SL Ellis
Keyword(s):  
Microscopic Examination ◽  
Phosphate Buffer ◽  
Primary Myelofibrosis ◽  
Transient Increase ◽  
Major Difficulty ◽  
Adult Mice ◽  
Dense Cytoplasm

In effective thrombopoies is has been inferred to occur in several disease sates from considerations of megakaryocyte mass and platelet kinetics. Microscopic examination has demonstrated increased numbers of megakaryocytes, with a typical forms particularly pronounced, in primary myelofibrosis. It has not been documented if megakaryocyte ever fail to reach maturity in non-pathological situations. A major difficulty of establishing this is that the number of megakaryocytes normally present in the marrow is extremely low. A large transient increase in megakaryocytopoiesis can how ever be induced in mice by an injection of 5-fluorouracil. We have utilised this treatment and report here evidence for in effective thrombopoies is in healthy mice.Adult mice were perfused (2% glutaraldehyde in 0.08M phosphate buffer, pH 7.4) 8 days following an injection of 5-fluorouracil (150mg/kg). Femurs were subsequently decalcified in 10% neutral E.D.T.A. and embedded in Spurrs resin. Transverse sections of marrow revealed many megakaryocytes at various stages of maturity. Occasional megakaryocytes (less than 1%) were found to be under going degeneration prior to achieving full maturation and releasing cytoplasm as platelets. These cells were characterized by a peripheral rim of dense cytoplasm which enveloped a mass of organelles and vacuoles (Fig. 1). Numerous microtubules were foundaround and with in the organelle-rich zone (Fig 2).

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp (Ctenopharyngodon idellus) via suppression of oxidative stress, inflammation and apoptosis

2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Human Health ◽  
Grass Carp ◽  
Aquatic Environment ◽  
Ctenopharyngodon Idellus

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.

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