scholarly journals Relapse and Outcome of Lupus Nephritis After Renal Transplantation in the Modern Immunosuppressive Era

Cureus ◽  
2022 ◽  
Author(s):  
Debendra Pattanaik ◽  
Joseph Green ◽  
Manish Talwar ◽  
Miklos Molnar
Keyword(s):  
Renal Transplantation ◽  
Lupus Nephritis

Outcome of renal transplantation under cyclosporine immunosuppression in patients with lupus nephritis

2000 ◽  
Vol 32 (7) ◽  
pp. 1826-1827 ◽  
Author(s):  
J Cobankiat ◽  
A Vathsala ◽  
Y.M Lu ◽  
K.T Woo
Keyword(s):  
Renal Transplantation ◽  
Lupus Nephritis

A Case Report of Recurrent Lupus Nephritis 15 Days After Renal Transplantation

2020 ◽  
Vol 52 (2) ◽  
pp. 614-618
Author(s):  
Lily A. Romero Karam ◽  
Amol M. Patel ◽  
Luan Truong ◽  
Juan M. Gonzalez
Keyword(s):  
Case Report ◽  
Renal Transplantation ◽  
Lupus Nephritis

scholarly journals Renal transplantation for lupus nephritis: non-adherence and graft survival

Lupus ◽  
2019 ◽  
Vol 28 (5) ◽  
pp. 651-657 ◽  
Author(s):  
E Ntatsaki ◽  
V S Vassiliou ◽  
A Velo-Garcia ◽  
A D Salama ◽  
D A Isenberg
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Transplantation ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Graft Rejection ◽  
Graft Failure ◽  
Immunosuppressive Treatment ◽  
Poor Adherence ◽  
Systemic Lupus ◽  
Group 2

Objectives Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated whether non-adherence is associated with increased rTp graft rejection and/or failure in patients with LN. Methods Patients with LN undergoing rTp in two major London hospitals were retrospectively included. Medical and electronic records were reviewed for documented concerns of non-adherence as well as laboratory biochemical drug levels. The role of non-adherence and other potential predictors of graft rejection/failure including demographics, comorbidities, age at systemic lupus erythematosus and LN diagnosis, type of LN, time on dialysis prior to rTp and medication use were investigated using logistic regression. Results Out of 361 patients with LN, 40 had rTp. During a median follow-up of 8.7 years, 17/40 (42.5%) of these patients had evidence of non-adherence. A total of 12 (30.0%) patients experienced graft rejection or failure or both. In the adherent group 2/23 (8.7%) had graft rejection, whilst in the non-adherent this rose to 5/17 (29.4%, p = 0.11). Graft failure was seen in 5/23 (21.7%) patients from the adherent group and 4/17 (23.5%) in the non-adherent group ( p = 0.89). Non-adherent patients had a trend towards increased graft rejection, hazard ratio 4.38, 95% confidence interval = 0.73–26.12, p = 0.11. Patients who spent more time on dialysis prior to rTp were more likely to be adherent to medication, p = 0.01. Conclusion Poor adherence to immunosuppressive therapy is common and has been shown to associate with a trend towards increased graft failure in patients with LN requiring rTp. This is the first paper to report that shorter periods on dialysis prior to transplantation might lead to increased non-adherence in lupus patients.

Renal transplantation in lupus nephritis

Lupus ◽  
2005 ◽  
Vol 14 (1) ◽  
pp. 95-98 ◽  
Author(s):  
C Ponticelli ◽  
G Moroni
Keyword(s):  
Renal Transplantation ◽  
Lupus Nephritis

Renal transplantation in lupus nephritis: a Brazilian cohort

Lupus ◽  
2011 ◽  
Vol 21 (5) ◽  
pp. 570-574 ◽  
Author(s):  
CS Oliveira ◽  
I d`Oliveira ◽  
ABS Bacchiega ◽  
EM Klumb ◽  
EMM Albuquerque ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Lupus Nephritis ◽  
Brazilian Cohort

RENAL TRANSPLANTATION FOR SYSTEMIC LUPUS ERYTHEMATOSUS AND RECURRENT LUPUS NEPHRITIS

1991 ◽  
Vol 52 (5) ◽  
pp. 805-809 ◽  
Author(s):  
JOHN A. GOSS ◽  
BARBARA R. COLE ◽  
MARTIN D. JENDRISAK ◽  
CHRISTOPHER S. MCCULLOUGH ◽  
SAMUEL K. S. SO ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Transplantation ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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