scholarly journals Dermatologic and Ophthalmologic Treatment of Erythema Multiforme Major: A Case Report

Cureus ◽  
2021 ◽  
Author(s):  
Barbara Senger ◽  
Shayan A Memar ◽  
Alex Ahmann ◽  
Jeremy J Houser ◽  
Lauren Doughty-McDonald
2021 ◽  
Vol 9 ◽  
Author(s):  
Xiaomei Fan ◽  
Yong Luo ◽  
Jieluan Lu ◽  
Jinji Xu ◽  
Qing Chen ◽  
...  

Background: Erythema multiforme (EM) is an acute immune-mediated inflammatory mucinous skin disorder. The etiology of pediatric EM involves infections, medications, autoimmune diseases, and genetic factors.Case Report: An 8-year-old girl with Mycoplasma pneumoniae (MP) associated community-acquired pneumonia developed erythema target-like symptoms 1 week after azithromycin administration. The erythema quickly spread throughout the body involving the oral and ocular mucous membranes, the trunk, and the extremities, and eventually developed into erythema multiform major (EMM). Through drug withdrawal and specific treatment including systemic corticosteroids and supportive care, her clinical symptoms were improved. After 31 days, most of the mucocutaneous symptoms were relieved, except pigmentation. Human leukocyte antigen (HLA) gene sequencing was performed and 20 HLA genotypes were identified. The patient follow-up lasted for 18 months. Rashes appeared on her trunk when receiving azithromycin orally after discharge and then disappeared after azithromycin withdrawal.Conclusions: Pediatric EM is a rare disease and recognition of its etiology is important for EM management. In this case, azithromycin and HLA-DQB1*03:01 genotype may contribute to EMM.Lesson: For drug-induced EM, rapid identification and withdrawal of the causative drugs is critical. Re-exposure to the same drug or exposure to drugs with similar chemical structures should also be avoided. Patient education and rational use of medicines are essential for pediatric patients.


2016 ◽  
Vol 121 (1) ◽  
pp. e10-e15 ◽  
Author(s):  
Andre A. Farquharson ◽  
Eric T. Stoopler ◽  
Alicia M. Houston ◽  
Ronald S. Brown

2016 ◽  
Vol 27 ◽  
pp. vii105
Author(s):  
Junya Makiyama ◽  
Hideki Kitanosono ◽  
Yuji Moriwaki ◽  
Tetsuo Shukuwa ◽  
Shinichiro Yoshida

2014 ◽  
Vol 02 (03) ◽  
pp. 166-168
Author(s):  
Neha Gupta ◽  
Amol Bansal ◽  
Aarti Bansal

AbstractErythema Multiforme is a rare, acute, inflammatory mucocutaneous condition caused by a hypersensitivity reaction with the appearance of cytotoxic T lymphocytes in the epithelium that induce apoptosis in keratinocytes, which leads to satellite cell necrosis. Reactions to drugs are quite common and are generally mild, hence not reported. However, occasionally life threatening reactions including Erythema multiforme major (Steven Johnson’s syndrome) and Toxic Epidermal Necrolysis may occur. A wide spectrum of drugs can sometimes give rise to Erythema Multiforme. We report a case of Erythema Multiforme following administration of Non Steroidal Anti-Inflammatory Drugs.


Author(s):  
Hirokazu Saito ◽  
Yurie Akiyama ◽  
Chiho (Kondo) Hiraga ◽  
Taiki Suzuki ◽  
Satoru Ogane ◽  
...  

2021 ◽  
Vol 15 (1) ◽  
pp. 222-225
Author(s):  
Amanda de Paula Magalhães ◽  
Juliana Allázia Balbino ◽  
Stella Cristina Soares Araújo ◽  
Fabiana de Freitas Bombarda-Nunes ◽  
Fernanda Mombrini Pigatti

Author(s):  
Shoko Hattori ◽  
Fumi Miyagawa ◽  
Keiko Fukuda ◽  
Kohei Ogawa ◽  
Hideo Asada

Abstract is missing (Short communication)


2017 ◽  
Vol 24 (2) ◽  
Author(s):  
Sajad Ahmad Buch ◽  
Subhas G. Babu ◽  
Renita Lorina Castelino ◽  
Shruthi Rao ◽  
Kumuda Rao ◽  
...  

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