scholarly journals Peritoneal Tuberculosis in a Young Healthy Male Resembling Intra-Abdominal Malignancy

Cureus ◽  
2021 ◽  
Author(s):  
Rema F Alrashed ◽  
Alhanouf A Alkhuwaylidi ◽  
Khloud A Aldashash ◽  
Naif A Albati ◽  
Abdullah A Algarni ◽  
...  
Keyword(s):  
Peritoneal Tuberculosis ◽  
Healthy Male ◽  
Abdominal Malignancy

scholarly journals Clinical and Laboratory Characteristics of Patients with Peritoneal Tuberculosis Mimicking Advanced Ovarian Cancer

2021 ◽  
Vol 10 (02) ◽  
pp. 102-106
Author(s):  
Amita Maheshwari ◽  
Sudeep Gupta ◽  
Shweta Rai ◽  
Bharat Rekhi ◽  
Rohini Kelkar ◽  
...  
Keyword(s):  
Ascitic Fluid ◽  
Advanced Ovarian Cancer ◽  
Ca 125 ◽  
Cancer Center ◽  
Peritoneal Tuberculosis ◽  
Surgical Biopsy ◽  
Primary Peritoneal Cancer ◽  
Peritoneal Cancer ◽  
Study Results ◽  
Abdominal Malignancy

Abstract Objectives Peritoneal tuberculosis can mimic advanced abdominal malignancy. We describe clinical and laboratory characteristics in a series of female patients with peritoneal tuberculosis who were referred to a tertiary cancer center with a diagnosis of suspected advanced ovarian/primary peritoneal cancer. Materials and Methods Details of clinical features, laboratory results including serum tumor markers, radiological findings, and ascitic fluid evaluation were retrospectively collected from hospital records for patients diagnosed to have peritoneal tuberculosis and reported descriptively. Statistical Analysis Descriptive statistics was performed using SPSS Statistics for Windows software, version 20.0 (SPSS, Chicago, Illinois). Results Between January 2009 and December 2017, 120 patients of peritoneal tuberculosis with a median age 41 years (range, 15–79 years) were identified. Of these 112 (93.3%; 95% CI 88.9–97.8%) patients had ascites and 63 (52.5%; 95% CI 43.6–61.4%) had adnexal mass at presentation. Mean serum cancer antigen 125 (CA-125) level was 666.9 (range, 38–18,554) U/mL. Ascitic fluid was negative for malignant cells in all patients and lymphocyte rich exudate was seen in 103 (91.9%; 86.9–97.0%) patients. Ascitic fluid adenosine deaminase (ADA) level was more than 40 U/L in 107 (95.5%; 95% CI 91.7–99.4%). Ascitic fluid Ziel–Neelsen staining was positive in 4/62 (6.5%; 95% CI 0.3–12.6%) patients while ascitic fluid culture examination for mycobacterium tuberculosis was positive in 7/59 (11.9%; 95% CI 3.6–20.1%) patients. The diagnosis of tuberculosis was based on image-guided biopsy in 44 (36.7%) patients, surgical biopsy in 8 (6.7%) patients, and a combination of clinicoradiological and laboratory features in 68 (56.7%) patients. All patients received standard antitubercular treatment. Conclusions The study results suggest that peritoneal tuberculosis has clinical, radiological, and serological profile which may mimic advanced ovarian/primary peritoneal cancer. Peritoneal tuberculosis should be considered in the differential diagnosis of advanced abdominal malignancy.

884: Phase I, Double-Blind, Placebo-Controlled Study in Healthy Male Subjects to Investigate the Safety, Tolerability, and Pharmacokinetics of DA-8159

2004 ◽  
Vol 171 (4S) ◽  
pp. 234-234 ◽  
Author(s):  
Harin Padma-Nathan ◽  
Jae Seung Pacik ◽  
Byoung Ok Ahn ◽  
Kyung Koo Kang ◽  
Mi Young Bahng ◽  
...  
Keyword(s):  
Phase I ◽  
Controlled Study ◽  
Healthy Male ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Male Subjects

Physical Exercise Induces Enhancement of Urokinase-Type Plasminogen Activator (u-PA) Levels in Plasma

1991 ◽  
Vol 65 (01) ◽  
pp. 082-086 ◽  
Author(s):  
G Dooijewaard ◽  
A de Boer ◽  
P N C Turion ◽  
A F Cohen ◽  
D D Breimer ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Plasminogen Activator ◽  
Maximal Exercise ◽  
Normal Values ◽  
Bicycle Ergometer ◽  
Tissue Type ◽  
Healthy Male ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Fibrinolytic Potential

SummaryThe enhancement of the blood fibrinolytic potential by physical exercise is generally attributed to the release of tissue-type plasminogen activator (t-PA) from the vessel wall. In this study we have investigated the possible contribution of urokinase-type plasminogen activator (u-PA).Six healthy male volunteers (age 21–25 years) were screened for their ability to perform maximal exercise for their age-group for 12 min on a bicycle ergometer. Subsequently, on one occasion they were required to remain supine for 2 h (from 8.30 a. m. onwards) and on another they performed maximal exercise (from 9.00 a.m. onwards). During exercise an increase in u-PA antigen and plasmin-activatable pro-urokinase (proUK) activity, concurrent with t-PA antigen and euglobulin t-PA activity, was observed in all six volunteers, while at rest these parameters remained unaffected. Mean u-PA- and t-PA antigen increased, respectively, from 4.2 ± 1.0 ng/ml and 5.8 ± 2.1 ng/ml before exercise to 9.8 ± 3.0 ng/ml and 18.3 ± 3.8 ng/ml (peak). Mean plasminactivatable proUK activity and t-PA activity increased, respectively, from 2.1 ± 0.4 ng/ml and 0.3 ± 0.2 ng/ml before exercise to 4.3 ± 1.7 ng/ml and 7.2 ± 4.0 ng/ml (peak). The increases were statistically significant throughout (paired t-test, pre vs post, antigen P <0.005 and activity P <0.02). After cessation of exercise u-PA and t-PA declined concurrently to normal values with a 50"/" decay in about 5 min. In conclusion, we found that both u-PA antigen and plasmin-activatable proUK activity are, concurrently with t-PA, enhanced upon exercise and, therefore, we consider that u-PA also contributes to – and co-operates in – the enhancement of the blood fibrinolytic potential and activity under these conditions.

Preparation and Standardization of a Stable AHF Plasma

1968 ◽  
Vol 19 (03/04) ◽  
pp. 423-429 ◽  
Author(s):  
G. M Thelin ◽  
Keyword(s):  
Moisture Content ◽  
Primary Standard ◽  
Healthy Male ◽  
Healthy Donors ◽  
Fresh Plasma

SummaryA stable, lyophilized AHF reference plasma has been prepared from pooled plasma from at least 50 normal healthy donors and standardized against a primary standard of fresh plasma from 20 healthy male donors aged 20 to 40. Average AHF potency of a typical lot is 98.8%, and moisture content is less than 0.5%. Under storage at -25° C, this AHF reference plasma is stable for at least 18 months. It has been used in several major coagulation laboratories, and has given consistently satisfactory and reproducible results in AHF assays.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

Glucocorticoid treatment is associated with dose-dependent insulin resistance in healthy male volunteers

2019 ◽  
Author(s):  
Riccardo Pofi ◽  
Ilaria Bonaventura ◽  
Nanthia Othonos ◽  
Thomas Marjot ◽  
Ahmed Moolla ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Healthy Male ◽  
Glucocorticoid Treatment ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Dose Dependent

Evaluation of Renal Function of Apparently Healthy Male Cannabis Smokers of College of Health Sciences, Nnewi Campus, Anambra State, Nigeria

2018 ◽  
Vol 4 (01) ◽  
Author(s):  
Analike Rosemary Adamma ◽  
Emekwue Loveth ◽  
Ogbodo Emmanuel Chukwuemeka ◽  
Ezeugwunne Ifeoma Priscilla ◽  
Onoh Joy Obioma ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cannabis Sativa ◽  
Demographic Data ◽  
Cannabis Use ◽  
Total Carbon ◽  
Total Calcium ◽  
Healthy Male ◽  
Anambra State ◽  
Control Subjects ◽  
Apparently Healthy

The use of Cannabis sativa is on the increase worldwide especially among adolescents and youths. This study investigated the effect of cannabis smoking on renal functions in young and apparently healthy male students of Nnamdi Azikiwe University, Nnewi campus, Anambra state, Nigeria. A total of 60 male (40 cannabis smokers and 20 controls) subjects participated in this study. A well-structured questionnaire was used to obtain the demographic data and anthropometric of subjects. Thereafter, 5mls of fasting blood sample was collected from the subjects into plain container for the estimation of biochemical parameters (creatinine, urea, uric acid, electrolytes). Renal parameters were estimated using standard methods. Data obtained were statistically analyzed using paired student t-test and pearson r correlation. Result showed that the mean serum levels of urea, creatinine, K+, Na+, Cl-, ionized calcium, total calcium, total carbon dioxide, anion gap, and pH were not significantly different in both smokers and control subjects(p>0.05). However, there was significantly higher mean serum level of uric acid (2.42 ± 38.54 vs 1.92 ± 41.61; p<0.05) and total calcium (16.0 ± 0.30 vs 10.24 ± 0.18; p<0.05) in smokers compared with control subjects. Again, BMI was significantly higher in smokers compared with non-smokers (23.96 ± 3.15; p<0.05 Vs 21.95 ± 2.17; p<0.05). Therefore, cannabis use had no deleterious effect on the kidneys, but the significantly higher uric acid levels in the smokers may provide some anti-oxidant protection. However, further studies are necessary to further unravel the full potentials of cannabis use.

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