scholarly journals Native Valve Aspergillus Endocarditis in a Non-Neutropenic Immunocompromised Patient on Anti-TNF α Blockers Therapy

Cureus ◽  
2021 ◽  
Author(s):  
Joana Azevedo Carvalho ◽  
Leonor Boavida ◽  
Isabel Amorim Ferreira ◽  
Bruno Grima ◽  
José Delgado Alves
Keyword(s):  
Immunocompromised Patient ◽  
Native Valve ◽  
Tnf Α

Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-α Inhibitor Treatment: Management and Control

2015 ◽  
Vol 36 (11) ◽  
pp. 1358-1360 ◽  
Author(s):  
Valeria Belvisi ◽  
Giovanni Battista Orsi ◽  
Cosmo Del Borgo ◽  
Paolo Fabietti ◽  
Adriana Ianari ◽  
...  
Keyword(s):  
Index Case ◽  
Immunocompromised Patient ◽  
Parasitic Infection ◽  
Nosocomial Outbreak ◽  
Biologic Therapies ◽  
Psoriasis Arthritis ◽  
Tnf Α ◽  
Large Outbreak ◽  
And Control ◽  
Inhibitor Treatment

We describe a large outbreak associated with a crusted (Norwegian) scabies case in an immunocompromised patient following treatment with TNF-α inhibitor (adalimumab) for psoriasis arthritis. The increasing use of TNF-α inhibitors should induce clinicians to consider this serious parasitic infection when evaluating skin rashes in patients receiving biologic therapies.Infect. Control Hosp. Epidemiol. 2015;36(11):1358–1360

scholarly journals A case of native valve infective endocarditis in an immunocompromised patient

2012 ◽  
Vol 31 (1) ◽  
pp. 35-38
Author(s):  
Maria Salomé Carvalho ◽  
Marisa Trabulo ◽  
Regina Ribeiras ◽  
João Abecasis ◽  
Fernando Leal da Costa ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Immunocompromised Patient ◽  
Native Valve

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

A PPARψ agonist improved diabetic state via decreasing TNF-α without any change including obesity in genetically obese diabetic rats

2001 ◽  
Vol 120 (5) ◽  
pp. A674-A674 ◽  
Author(s):  
A FUNAKOSHI ◽  
M ICHIKAWA ◽  
Y SATO ◽  
S KANAI ◽  
M OHTA ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Diabetic State ◽  
Tnf Α ◽  
Obese Diabetic Rats

Role of cytokines in caerulein-induced acute pancreatilis of IL-1, IL-6 and TNF-α knockoul mice

2001 ◽  
Vol 120 (5) ◽  
pp. A541-A541
Author(s):  
K KITAMURA ◽  
J NIIKAWA ◽  
T IMAMURA ◽  
A TAKAHASHI ◽  
A IKEGAMI ◽  
...  
Keyword(s):  
Tnf Α

TNF-α Inhibitors May Raise Coccidioidomycosis Risk

2007 ◽  
Vol 38 (5) ◽  
pp. 46
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Tnf Α

TNF-α Blockers Can Trigger Palmoplantar Psoriasis

2007 ◽  
Vol 38 (6) ◽  
pp. 58
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Tnf Α
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