scholarly journals When a Late Metastasis Is Hard to Swallow

Cureus ◽  
2021 ◽  
Author(s):  
Catarina Negrão ◽  
Rita Sismeiro ◽  
Margarida Monteiro ◽  
Filipa G Pereira ◽  
Marta Jonet
Keyword(s):  
Late Metastasis

Prediction of late metastasis in node-negative breast cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 10551-10551
Author(s):  
Marcus Schmidt ◽  
Birte Hellwig ◽  
Mathias Gehrmann ◽  
Heinz Koelbl ◽  
Daniel Boehm ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Gene Array ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Node Negative Breast Cancer ◽  
Increased Risk ◽  
Late Metastasis

10551 Background: Prediction of late metastasis is of clinical relevance in breast cancer. However, systematic genome-wide studies to identify genes associated with increased risk of metastasis 5 or more years after surgery are scarce. Methods: We examined the natural course of disease in three previously published cohorts (Mainz, Rotterdam, Transbig) including 766 node-negative breast cancer patients with gene array data who did not receive systemic chemotherapy in the adjuvant setting. We established a Cox regression based method adjusted for multiple testing that identified genes predicting late metastasis (5 or more years after surgery). Only those genes were accepted that showed similar results in all three cohorts. Metastasis-free survival (MFS) was analyzed with univariate and multivariate Cox regression. Results: We identified 9 genes [ABCC5 (Hazard Ratio (HR) 2.19, p=0.003), EDDM3B (HR 3.58, p=0.044), RAD23B (HR 0.37, p<0.001), XYLT2 (HR 2.19, p=0.027), DDX18 (HR 0.35, p=0.006), GPBP1L1 (HR 0.20, p=0.018), UBB (HR 9.73, p=0.025), RPS24 (HR 0.20, p=0.050), GPC1 (HR 2.36, p=0.013)] predicting late metastasis. These genes retained their independent prognostic significance after adjustment for established clinical factors (age, tumor size, grade, hormone receptor status, HER2) and biological motives like estrogen receptor, proliferation, B or T cells. These late-type genes are largely associated with resistance to hypoxia, apoptosis and DNA damage, suggesting that they might contribute to persistence of disseminated tumor cells. Conclusions: Genes associated with late metastasis offer a perspective to identify breast cancer patients suitable for additional and prolonged therapies.

Low-grade ependymoma with late metastasis: autopsy case study and literature review

2015 ◽  
Vol 31 (9) ◽  
pp. 1565-1572 ◽  
Author(s):  
Wael Alshaya ◽  
Vivek Mehta ◽  
Beverly A. Wilson ◽  
Susan Chafe ◽  
Keith E. Aronyk ◽  
...  
Keyword(s):  
Literature Review ◽  
Low Grade ◽  
Autopsy Case ◽  
Late Metastasis

scholarly journals Unusual late metastasis from gastric carcinoma

2011 ◽  
Vol 17 (6) ◽  
pp. 423 ◽  
Author(s):  
Juan Marti ◽  
Marta Sainz
Keyword(s):  
Gastric Carcinoma ◽  
Late Metastasis

scholarly journals Malignant chondroid syringoma of thigh with late metastasis to lung: A very rare case report

2017 ◽  
Vol 60 (3) ◽  
pp. 418
Author(s):  
Neha Mittal ◽  
Mayur Kothiya ◽  
Rajiv Kumar ◽  
Shubhada Kane
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Chondroid Syringoma ◽  
Rare Case Report ◽  
Late Metastasis

scholarly journals A Case of Amelanotic Malignant Melanoma of the Lingual Base That Was Diagnosed Based on a Biopsy of Late Metastasis to a Lumbar Vertebra after Being Misdiagnosed as HPV-Positive Oropharyngeal Anterior Wall Squamous Cell Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Takumi Okuda ◽  
Shinsuke Ide ◽  
Kei Kajihara ◽  
Tetsuya Tono
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lumbar Vertebra ◽  
Anterior Wall ◽  
Amelanotic Malignant Melanoma ◽  
P16 Protein ◽  
Poorly Differentiated ◽  
Late Metastasis

We report a case of amelanotic malignant melanoma (AMM) in a 66-year-old female. AMM of the lingual base was diagnosed based on a biopsy of late metastasis to the bone marrow of the L4 lumbar vertebra. The patient was initially treated with chemoradiotherapy after being misdiagnosed with poorly differentiated human papillomavirus- (HPV-) related squamous cell carcinoma of the oropharyngeal anterior wall. p16 immunostaining is used to diagnose HPV-related oropharyngeal cancer. However, while p16 expression is used as a surrogate marker of HPV infection, it is important to be aware that p16 protein overexpression can also be caused by other factors. Malignant melanoma is known to express the p16 protein. Morphologically differentiating between AMM and poorly differentiated squamous cell carcinoma based on hematoxylin-eosin staining is difficult. Therefore, in cases that are pathologically diagnosed as p16-positive poorly differentiated oropharyngeal squamous cell carcinoma, it is important to rule out AMM.

scholarly journals Therapy for hilar cholangiocarcinoma

2019 ◽  
Vol 18 (1) ◽  
pp. 103-115 ◽  
Author(s):  
D. Yu. Frantsev ◽  
O. N. Sergeeva ◽  
B. I. Dolgushin
Keyword(s):  
Hilar Cholangiocarcinoma ◽  
Biliary Stricture ◽  
Klatskin Tumor ◽  
Biliary Decompression ◽  
Tumor Patients ◽  
Dismal Prognosis ◽  
Significant Prolongation ◽  
Tumor Material ◽  
Late Metastasis ◽  
Transhepatic Biliary Drainage

Purpose: to present different modalities of biliary decompression and specific antitumor treatment of hilar cholangiocarcinoma (Klatkin tumor). material and methods. The review was based on 318 publications available from Pubmed, Medline, Elibrary, etc. in the interval time between 19212018. results. Hilar cholangiocarcinoma is a rare hepatobiliary malignancy with dismal prognosis demonstrating slow periductal infiltrative growth, late metastasis and causing death mainly due to local complications. Percutaneous transhepatic biliary drainage (PTBD) is the optimal way of biliary decompression for malignant hilar strictures nowadays. PTBD is the safest, technically accessible technique with reproducible results. Transpapillary decompression in Klatskin tumor patients is technically feasible in 40 % of cases only. Biliary resection accompanied by major hepatectomy is considered the only curative modality to the date, but its results aren’t satisfactory a well as the majority of patients aren’t seemed the surgical candidates. Thus the locoregional technologies, i.e. radiation therapy, radiofrequency ablation and photodynamic therapy (PDT), are widely spread. PDT should be preferred over other local modalities due to safety, efficiency, possibility of reinterventions, technical and economic accessibility. conclusion. Modern approaches to the management of Klatskin tumor do not differ much from the those proposed by the first researchers in the middle of the xxth century and comes down to the biliary stricture dilatation and the sustenance of the normal bile passage as long as possible. However, despite the strategic stagnation, significant tactical successes were achieved thus allowing significant prolongation of survival in previously considered incurable patients.

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