scholarly journals Multidrug-Resistant Stenotrophomonas maltophilia Keratitis in a Penetrating Keratoplasty Patient

Cureus ◽  
2021 ◽  
Author(s):  
Nikhil Thakral ◽  
Fraser S Peck ◽  
Pantelis Ioannidis
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Penetrating Keratoplasty ◽  
Multidrug Resistant

scholarly journals Corrigendum to “high diversity of virulent and multidrug resistant Stenotrophomonas maltophilia in Iraq” gene reports, volume 23 (2021)

Gene Reports ◽  
2021 ◽  
pp. 101264
Author(s):  
Raed Obaid Saleh ◽  
Bashdar Mahmud Hussen ◽  
Shaden M.H. Mubarak ◽  
Seyyed Khalil Shokouhi Mostafavi
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Multidrug Resistant ◽  
High Diversity

Tolerance to glyphosate and antibiotic resistance in gram-negative bacteria isolated from soils of different agricultural management systems in Ceará, Brazil

Gaia Scientia ◽  
2021 ◽  
Vol 15 (2) ◽  
Author(s):  
Raul Vítor Ferreira de Oliveira ◽  
Margareth Borges Coutinho Gallo ◽  
Oscarina Viana de Sousa ◽  
Álef Vasconcelos Ribeiro ◽  
Tatiana Salata Lima ◽  
...  
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Selective Pressure ◽  
Multidrug Resistant ◽  
Agricultural Management ◽  
Management Systems ◽  
Cross Resistance ◽  
Gram Negative Bacteria ◽  
Conventional Farming ◽  
Gram Negative ◽  
Opportunistic Bacteria

Brazil is among the world’s largest consumers of pesticides, with glyphosate (GLY) being the most commercialized herbicide in the country. Studies showed microorganisms suffer selective pressure when exposed to pesticides, developing tolerance to pesticides and resistance to antibiotics (ABs), in a phenomenon known as “cross-resistance”. The present work aimed to evaluate the occurrence of glyphosate-tolerance and AB-resistance in bacteria isolated from different agricultural management systems in Ceará State, Brazil. Gram-negative bacteria isolated from agroforestry (S1), conventional farming (S2) and uncultivated (S3) soils were cultured in the presence of 1.6% acid glyphosate. Overall, 58 strains were isolated. Soils S1 and S2 presented several multidrug resistant (MDR) strains, the majority resistant to ampicilin. Although there was a small percentage of strains resistant to ertapenem (33%, soil S1), the fact they were found is concerning, as Carbapenem antibiotics are used to treat clinical cases of MDR bacteria, which are not common outside hospital settings. Stenotrophomonas maltophilia (soil S2), resistant to six of the eight ABs tested, was identified by MALDI-TOF mass spectrometry, and was found as one of the most common opportunistic bacteria in ICUs of Ceará hospitals.

scholarly journals The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Matthias I. Gröschel ◽  
Conor J. Meehan ◽  
Ivan Barilar ◽  
Margo Diricks ◽  
Aitor Gonzaga ◽  
...  
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Multidrug Resistant

scholarly journals Genome Sequence of a Multidrug-Resistant Strain of Stenotrophomonas maltophilia with Carbapenem Resistance, Isolated from King Abdullah Medical City, Makkah, Saudi Arabia

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Alyaa M. Abdel-Haleem ◽  
Zineb Rchiad ◽  
Babar K. Khan ◽  
Abdallah M. Abdallah ◽  
Raeece Naeem ◽  
...  
Keyword(s):  
Health Care ◽  
Saudi Arabia ◽  
Genome Sequence ◽  
Stenotrophomonas Maltophilia ◽  
Draft Genome ◽  
Carbapenem Resistance ◽  
Multidrug Resistant ◽  
Medical City ◽  
Health Care Associated Infections ◽  
Multidrug Resistant Strain

The emergence and spread of multidrug-resistant (MDR) bacteria have been regarded as major challenges among health care-associated infections worldwide. Here, we report the draft genome sequence of an MDR Stenotrophomonas maltophilia strain isolated in 2014 from King Abdulla Medical City, Makkah, Saudi Arabia.

scholarly journals In Vitro Bactericidal Activity of Human β-Defensin 3 against Multidrug-Resistant Nosocomial Strains

2006 ◽  
Vol 50 (2) ◽  
pp. 806-809 ◽  
Author(s):  
Giuseppantonio Maisetta ◽  
Giovanna Batoni ◽  
Semih Esin ◽  
Walter Florio ◽  
Daria Bottai ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Bactericidal Activity ◽  
Stenotrophomonas Maltophilia ◽  
Bactericidal Effect ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
Gram Negative

ABSTRACT The antimicrobial activity of human β-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.

scholarly journals Stenotrophomonas maltophilia strains replicate and persist in the murine lung, but to significantly different degrees

Microbiology ◽  
2011 ◽  
Vol 157 (7) ◽  
pp. 2133-2142 ◽  
Author(s):  
Ruella Rouf ◽  
Sara M. Karaba ◽  
Jenny Dao ◽  
Nicholas P. Cianciotto
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Fold Increase ◽  
Multidrug Resistant ◽  
Clinical Isolates ◽  
Mouse Strains ◽  
Mammalian Host ◽  
Virulence Determinants ◽  
Environmental Bacterium ◽  
Bacterial Replication ◽  
Pro Inflammatory Cytokines

The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of replicating in a mammalian host has been an issue of controversy. Using a model of intranasal inoculation into adult A/J mice, we now document that S. maltophilia strain K279a, the clinical isolate of S. maltophilia whose complete genome sequence was recently determined, is in fact capable of replicating in lungs, displaying as much as a 10-fold increase in c.f.u. in the first 8 h of infection. Importantly, as few as 104 c.f.u. deposited into the A/J lung was sufficient to promote bacterial outgrowth. Bacterial replication in the lungs of the A/J mice was followed by elevations in pro-inflammatory cytokines and also promoted resistance to subsequent challenge. We also found that DBA/2 mice were permissive for S. maltophilia K279a replication, although the level of growth and persistence in these animals was less than it was in the A/J mice. In contrast, the BALB/c and C57BL/6 mouse strains were non-permissive for S. maltophilia K279a growth. Interestingly, when five additional clinical isolates were introduced into the A/J lung, marked differences in survival were observed, with some strains being much less infective than K279a and others being appreciably more infective. These data suggest that the presence of major virulence determinants is variable among clinical isolates. Overall, this study confirms the infectivity of S. maltophilia for the mammalian host, and illustrates how both host and bacterial factors affect the outcome of Stenotrophomonas infection.

Post-antibiotic effect (PAE) of moxifloxacin in multidrug-resistant Stenotrophomonas maltophilia

2010 ◽  
Vol 36 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Ioannis Korakianitis ◽  
Vasiliki Mirtsou ◽  
Evangelia Gougoudi ◽  
Maria Raftogiannis ◽  
Evangelos J. Giamarellos-Bourboulis
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Multidrug Resistant ◽  
Antibiotic Effect ◽  
Post Antibiotic Effect
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