scholarly journals Hypertensive Emergency as the Initial Presentation of Acquired Thrombotic Thrombocytopenic Purpura: A Case Report

Cureus ◽  
2021 ◽  
Author(s):  
Diana I Zamora ◽  
Laura M Gonzalez
Keyword(s):  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Hypertensive Emergency ◽  
Initial Presentation ◽  
Thrombocytopenic Purpura

Effectiveness of bortezomib in the treatment of thrombotic thrombocytopenic purpura: Case report

2019 ◽  
Vol 152 (6) ◽  
pp. 244-245
Author(s):  
Eva Hernández Lorente ◽  
Rafael Lluch García ◽  
Emilio Monteagudo Santolaya
Keyword(s):  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

scholarly journals An Early Unexpected Immune Thrombotic Thrombocytopenic Purpura Relapse Associated with SARS-CoV-2 Infection: A Case Report and Literature Review

2021 ◽  
pp. 1-5
Author(s):  
Maya Kornowski Cohen ◽  
Liron Sheena ◽  
Yair Shafir ◽  
Vered Yahalom ◽  
Anat Gafter-Gvili ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Lupus Erythematosus ◽  
Response To Therapy ◽  
Intravascular Hemolysis ◽  
Systemic Lupus ◽  
Thrombocytopenic Purpura ◽  
History Of ◽  
Triggering Factor

SARS-CoV-2 has been reported as a possible triggering factor for the development of several autoimmune diseases and inflammatory dysregulation. Here, we present a case report of a woman with a history of systemic lupus erythematosus and antiphospholipid syndrome, presenting with concurrent COVID-19 infection and immune thrombotic thrombocytopenic purpura (TTP). The patient was treated with plasma exchange, steroids, and caplacizumab with initial good response to therapy. The course of both TTP and COVID-19 disease was mild. However, after ADAMTS-13 activity was normalized, the patient experienced an early unexpected TTP relapse manifested by intravascular hemolysis with stable platelet counts requiring further treatment. Only 3 cases of COVID-19 associated TTP were reported in the literature thus far. We summarize the literature and suggest that COVID-19 could act as a trigger for TTP, with good outcomes if recognized and treated early.

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