scholarly journals Chronic Endodontic Infections and Cardiovascular Diseases: Does the Evidence Support an Independent Association?

Cureus ◽  
2021 ◽  
Author(s):  
Yaser A Aloutaibi ◽  
Abdulaziz S Alkarim ◽  
Esraa M Qumri ◽  
Lolo A Almansour ◽  
Faisal T Alghamdi
Keyword(s):  
Cardiovascular Diseases ◽  
Endodontic Infections ◽  
Independent Association

scholarly journals A CROSS-SECTIONAL STUDY OF THE IMPACT OF ENDODONTIC INFECTIONS ON THE PATHOGENESIS OF CARDIOVASCULAR DISEASE

2020 ◽  
Vol 8 (12) ◽  
pp. 888-894
Author(s):  
Zainbganayah Hasan Sulimani ◽  
◽  
Manal Abdulaziz Murad ◽  
Amal Mohammed Abushal ◽  
Mohsen Daghustani ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Cross Sectional Study ◽  
Healthcare Organisation ◽  
Oral Diseases ◽  
Sectional Study ◽  
Cross Sectional ◽  
Endodontic Infections ◽  
The Impact ◽  
Inflammatory Burden

Introduction: The apical periodontitis possesses an association with the increased inflammatory markers levels, which contribute to the systematic immune response, leading towards systematic inflammation. The endodontic infections were reported to contribute to the CVD via the metastatic pathways however, there is a requirement to analyse the impact of endodontic infections on the pathogenesis of the cardiovascular disease. Aim:This research aims to assess the impact of endodontic infections on the pathogenesis of the cardiovascular disease. Material andMethod:This research was conducted using a cross-sectional research design by recruiting N=120 inpatients and outpatients visiting the healthcare organisation located in Saudi Arabia. Results:The endodontic infections are likely to increase the overall inflammatory burden, which might increase the risk of CVD among the individuals. Due to the multifactorial aetiology of CVD, the oral diseases are perceived to possess associated with the CVD. Thestatistical analysis revealed that there is no association between the presence of the lesion of endodontic origin and cardiovascular diseases. Conclusion:There is no association between the presence of the lesion of endodontic origin and cardiovascular diseases.

scholarly journals Dietary Acid Load and the Risk of Cardiovascular Disease: A Prospective Population-based Study

2021 ◽  
Author(s):  
Parvin Mirmiran ◽  
Zeinab Houshialsadat ◽  
Zahra Bahadoran ◽  
Sajjad Khalili‑Moghadam ◽  
Mohammad Karim Shahrzad ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Acid Production ◽  
Population Based ◽  
Dietary Acid Load ◽  
Potential Renal Acid Load ◽  
Net Endogenous Acid Production ◽  
Dietary Acid ◽  
Acid Load ◽  
Independent Association ◽  
Cox Proportional Hazard Regression

Abstract Background: Considering the established association between the dietary acid load and cardiovascular outcomes, as well as the existing inconstancies in the previous studies, we aimed to assess the association between the dietary acid load and the risk of cardiovascular diseases in the framework of the Tehran Lipid and Glucose Study. Methods: Eligible participants (n= 2369, 19- 70 years old, 43.5% men) with no cardiovascular diseases at baseline (2006-2008) were recruited and followed up for a mean period of 6.7 ± 1.4 years. Potential Renal Acid Load and Net Endogenous Acid Production, as the two indexes of dietary acid load, were calculated based on the macronutrient and micronutrient constitutions. The Cox proportional hazard regression model was used to report the association between tertiles of Potential Renal Acid Load and Net Endogenous Acid Production, and 6-years incident risk of cardiovascular diseases.Results: The mean age and body mass index of the participants were 38.5 ± 13.3 years and 26.6 ± 4.8 kg/m2 at baseline, respectively. The incident rate of cardiovascular diseases was reported as 3.3% (79 cases). No significant associations were detected between the Potential Renal Acid Load and the cardiovascular diseases incidence in the crude or the adjusted models (HRs= 0.63; CI: 0.36-1.17; P trend= 0.10). Meanwhile, the Net Endogenous Acid Production index was marginally significantly associated with the crude model (HR= 0.57; CI: 0.33-0.99, P trend= 0.048). Conclusions: Data from the current study were not in favor of an independent association between the dietary acid load and the incidence of cardiovascular diseases within the Iranian population.

Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

2020 ◽  
Vol 134 (17) ◽  
pp. 2243-2262
Author(s):  
Danlin Liu ◽  
Gavin Richardson ◽  
Fehmi M. Benli ◽  
Catherine Park ◽  
João V. de Souza ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Nlrp3 Inflammasome ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Therapeutic Interventions ◽  
Low Grade ◽  
Cardiovascular Research ◽  
Inflammatory Processes ◽  
Ach Receptors

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

Self-efficacy and quality of life among people with cardiovascular diseases: A meta-analysis.

2018 ◽  
Vol 63 (2) ◽  
pp. 295-312 ◽  
Author(s):  
Anna Banik ◽  
Ralf Schwarzer ◽  
Nina Knoll ◽  
Katarzyna Czekierda ◽  
Aleksandra Luszczynska
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Diseases ◽  
Self Efficacy ◽  
Meta Analysis

Apolipoprotein(a), Fibrinopeptide A and Carotid Atherosclerosis in Middle-Aged Men

1994 ◽  
Vol 72 (04) ◽  
pp. 563-566 ◽  
Author(s):  
Tuomo Rankinen ◽  
Sari Väisänen ◽  
Michele Mercuri ◽  
Rainer Rauramaa
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Bifurcation ◽  
Carotid Intima Media Thickness ◽  
Fibrinopeptide A ◽  
Carotid Imt ◽  
Apolipoprotein A ◽  
The Difference

SummaryThe association between apolipoprotein(a) [apo(a)], fibrinogen, fibrinopeptide A (FPA) and carotid intima-media thickness (IMT) was analyzed in Eastern Finnish men aged 50 to 60 years. Apo(a) correlated directly with carotid bifurcation (r = 0.26, p = 0.001), but not with common carotid IMT. Men in the lowest quartile of apo(a) had thinner (p = 0.013) IMT in bifurcation [1.59 mm (95% Cl 1.49; 1.68)] compared to the men in the highest [1.91 mm (95% Cl 1.73; 2.09)] apo(a) quartile. The difference remained (p=0.038) after adjusting for confounders. Plasma fibrinogen was not related to carotid IMT, whereas FPA correlated with common carotid (r = 0.21, p = 0.016) and carotid bifurcation (r = 0.21, p = 0.018) IMT. These associations abolished after adjusting for the confounders. The data suggest that apo(a) associate with carotid atherosclerosis independent of other risk factors for ischemic cardiovascular diseases.

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