scholarly journals The Spectrum of Autoimmune Liver Disorders, Clinical Presentation, and Autoantibodies in Patients From a Tertiary Care Center in Pakistan

Cureus ◽  
2021 ◽  
Author(s):  
Zaigham Abbas ◽  
Muhammad Asim ◽  
Alina Saeed ◽  
Basit Siddiqui ◽  
Minaam Abbas
Keyword(s):  
Clinical Presentation ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Liver Disorders

scholarly journals Clinical presentation of delusion of parasitosis in a tertiary care center

2019 ◽  
Vol 3 (1) ◽  
pp. 55
Author(s):  
Mahemubin Lahori ◽  
HemangManaharbhai Shah ◽  
Prakash Mehta
Keyword(s):  
Clinical Presentation ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center

scholarly journals Pattern of Sickle Cell Disorders: A Study from a Tertiary Care Center in Eastern Part of India

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 13-14
Author(s):  
Ankita Sen ◽  
Tuphan Kanti Dolai ◽  
Tuhin Suvra Gayen ◽  
Riya Roy ◽  
Aditi Sen ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Sickle Cell ◽  
Bone Pain ◽  
Clinical Presentation ◽  
Care Center ◽  
Tertiary Care ◽  
Study Cohort ◽  
Compound Heterozygous ◽  
Tertiary Care Center ◽  
Sickle Cell Disorders

Introduction:Sickle cell disorders were originally found in the African regions, Arabian Peninsula and parts of India. However, in today's age of globalization patients with homozygous or compound heterozygous Sickle cell disorders can be found all over the world. The objective of our study was to assess the distribution and clinical presentation of patients with Sickle homozygous or heterozygous diseases in the Eastern part of India. Methods:Patients who attended the Thalassemia Clinic in our tertiary care center, between 1st January 2018 to 31st May 2020 (2 years and 4 months) were retrospectively analysed and the ones with a component of Sickle haemoglobin(HbS), either in the form of Sickle cell anemia/homozygous Sickle cell disorders(SCA) or compound heterozygous diseases, like Sickle cell/β thalassemia(HbS/β), Sickle cell/Delta thalassemia(HbS/D), Sickle cell Haemoglobin/E thalassemia(HbS/E), were included in the study. People having Sickle cell trait (HbS trait), have also been included. Thorough history of painful crises, blood transfusions, family history and treatment history was elicited and every patient was clinically examined. The patients were diagnosed by High Pressure Liquid Chromatography (HPLC) or Thalassemia Mutation analysis by Polymerase Chain reaction (PCR). Results:A total of 95 patients with a component of HbS were considered as our study cohort, with HbS/β thalassemia patients being the majority (53.7%), followed by SCA (30.5%). Age of the study cohort ranged between 2-50 years age. HbS/β thalassemia patients presented at a later age (median 17.5 years) than SCA patients (median 12 years). Their demographic distribution is depicted in Table 1. The most common clinical presentation was painful crisis (32,33.7%), be it abdominal pain (11,11.6%) or bone pain (13,13.7%). Other presenting complaints were pallor (26,27.4%), jaundice (12,12.6%) and fever (4,4.2%). Some rarer presenting manifestations were fatigue (4,4.2%), splenic infarction (1,1%), convulsions (1,1%), Raynaud's phenomenon (1,1%), headache (1,1%) or itchy skin lesions (1,1%). Few patients (4,4.2%) had recurrent pregnancy loss, and one patient was diagnosed incidentally during an antenatal check-up. Most patients had more than one complaint. Very occasionally patients required hospital admission, the reasons being, chest pain, fever, convulsions or abdominal pain. HbS trait was diagnosed incidentally during evaluation for other illnesses, most commonly during evaluation of pallor (3,60%): one patient was later diagnosed with iron deficiency anemia. Most patients who attended our center were from within the state or neighbouring states. The patients were treated with Hydroxyurea, with/without blood transfusions, chelation therapy with Deferasirox as required and Folic acid supplementation. People with HbS Trait continued to receive Folate supplementation. Discussion and Conclusions:This study highlights the varied distribution of HbS among the population attending a tertiary care center, irrespective of a specific area-based population. Till date most studies conducted in India have highlighted the prevalence of Sickle cell disorders among specific focused populations. HbS/β thalassemia was the most common sickle cell disorder in our study. This is in contrast to most findings in published literature from other countries, where SCA is the commonest. Only one other study conducted in eastern India, has depicted a finding similar to ours. The median age of disease presentation was at a later age in our study, in contrast to findings in published literature from other countries. There is a variation in the severity of disease manifestation in our study cohort. The most common painful crisis was bone pain, followed by abdominal pain. Pallor was also one of the commonest presenting symptoms. Stroke, a common manifestation of SCA in other countries, was rare in our study cohort. Disclosures No relevant conflicts of interest to declare.

Clinical Presentation and Outcomes of Rhegmatogenous Retinal Detachments During the COVID-19 Lockdown and Its Aftermath at a Tertiary Care Center in Michigan

2021 ◽  
Vol 52 (11) ◽  
pp. 593-600
Author(s):  
Nicholas M. Carducci ◽  
Katie X. Li ◽  
Omar Moinuddin ◽  
Cagri G. Besirli ◽  
Thomas J. Wubben ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center

scholarly journals Clinical presentation and outcomes of patients with isolated subsegmental pulmonary embolism: A tertiary care center experience

2020 ◽  
Vol 25 (5) ◽  
pp. 468-470
Author(s):  
Tarun Dalia ◽  
Sagar Ranka ◽  
Nilay Patel ◽  
Matthew Lippmann ◽  
Michael Pierpoline ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Clinical Presentation ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center

scholarly journals Clinical profile, management and outcomes of class IV emphysematous pyelonephritis in a tertiary care center: A retrospective descriptive study

2021 ◽  
pp. 78-85
Author(s):  
R. Manjunath ◽  
M. Bennikal ◽  
S.K. Dasar ◽  
S.T. Patil
Keyword(s):  
Medical Management ◽  
Clinical Presentation ◽  
Care Center ◽  
Tertiary Care ◽  
First Episode ◽  
Tertiary Care Center ◽  
Long Term Outcomes ◽  
Emphysematous Pyelonephritis ◽  
Class Iv

Abstract. Class IV Emphysematous pyelonephritis (EPN) is a life-threatening infection of the kidney, and there is sparse data on immediate and long-term outcomes of medical management. The study aimed to review the clinical presentation, diagnosis, immediate and long-term outcomes of medical management, and outcome of patients presenting with class IV EPN Methods. This retrospective study was conducted in a tertiary care center in Dharwad, India. The study included class IV EPN patients admitted to the hospital between Jan 2012 to Dec 2019. The factors studied were demographics, comorbidities, radiological investigations, clinical presentation, urine, blood and pus culture, and sensitivity and treatment history. Immediate and long-term outcomes of medical management were determined. Descriptive analysis of the data was conducted. Continuous variables were presented as mean ± standard deviation and discrete variables in terms of number (%). Results. Twenty-one patients with class IV EPN, with a mean age of 55.7 ±13.5 years, were analyzed. The majority were males (M: F 15:6). The patients were followed up for 32.70±21.12 months. Fever, flank or abdominal pain, and acute kidney injury were observed in all 21 patients, while nausea and/or vomiting and dysuria were seen in 16 (76.2%) patients. E. Coli was the most common pathogen found. Double J stenting was done in 20 (95.2%) patients; Ultrasonography guided aspiration 8(38.1%) and percutaneous drainage in 5 (23.8%) patients. One (4.8%) patient died during the first episode and 3(19%) others due to recurrent infection and end-stage renal disease. Conclusions. Class IV Emphysematous pyelonephritis can be managed successfully by minimally invasive modalities. However, long-term morbidity and mortality risks are still negative.

scholarly journals Clinical presentation, etiology, management, and outcomes of iliopsoas abscess from a tertiary care center in South India

2017 ◽  
Vol 6 (4) ◽  
pp. 836 ◽  
Author(s):  
Ramya Iyyadurai ◽  
Joanne Rodrigues ◽  
Sowmya Sathyendra ◽  
Manjeera Jagannati ◽  
KundavaramPaul Prabhakar Abhilash ◽  
...  
Keyword(s):  
South India ◽  
Clinical Presentation ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Iliopsoas Abscess
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