scholarly journals Lateral Bowing of Femur Associated With Older Age, Shorter Stature, and Lower Bone Mineral Density

Cureus ◽  
2021 ◽  
Author(s):  
Yasuhiro Furihata ◽  
Tetsuhiro Ishikawa ◽  
Joe Katsuragi ◽  
Takanori Omae ◽  
Yasuhito Sasaki ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Older Age ◽  
Lower Bone Mineral Density ◽  
Mineral Density

scholarly journals Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

2018 ◽  
Vol 53 (4) ◽  
Author(s):  
Melina Bezerra Loureiro ◽  
Marcela Abbott Galvão Ururahy ◽  
Karla Simone Costa de Souza ◽  
Yonara Monique da Costa Oliveira ◽  
Heglayne Pereira Vital da Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Lower Bone Mineral Density ◽  
Mineral Density

scholarly journals Lower bone mineral density in older female endurance skiers – a cross-sectional, observational study

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Anne K. Gulsvik ◽  
Marius Myrstad ◽  
Ida Wilson Landgraff ◽  
Nina Emaus ◽  
Anette Hylen Ranhoff
Keyword(s):  
Bone Mineral Density ◽  
Observational Study ◽  
Bone Mineral ◽  
Lower Bone Mineral Density ◽  
Mineral Density ◽  
Cross Sectional

Iron Overload Associated Endocrine Dysfunction Leading to Lower Bone Mineral Density in Thalassemia Major

2020 ◽  
Vol 105 (4) ◽  
pp. e1015-e1024
Author(s):  
Wen-Ping Yang ◽  
Hsiu-Hao Chang ◽  
Hung-Yuan Li ◽  
Ying-Chuen Lai ◽  
Tse-Ying Huang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Iron Overload ◽  
Bone Mineral ◽  
Fibroblast Growth Factor 23 ◽  
Body Height ◽  
Thalassemia Major ◽  
Lower Bone Mineral Density ◽  
Mineral Density ◽  
Fracture History ◽  
The Mean

Abstract Context Patients with thalassemia major (TM) have a lower bone mineral density (BMD) and higher risk of fracture than the general population. The possible mechanisms include anemia, iron overload, malnutrition, and hormonal deficiency, but these have not been thoroughly investigated. Objective To identify major mineral and hormonal factors related to BMD in adult TM patients to provide human evidence for the proposed mechanisms. Design Retrospective study. Setting Referral center. Patients Twenty-nine patients with β-TM, aged 23 to 44 years who were followed-up during 2017 to 2018 were enrolled. Outcome measurements Endocrine profiles, including thyroid, parathyroid, and pituitary function, glucose, vitamin D, calcium, phosphate, and fibroblast growth factor 23 (FGF23) were obtained. The relationships among the above parameters, body height, fractures, and BMD were analyzed. Results Abnormal BMD was observed in 42.9% of women and 23.1% of men. The mean final heights of women and men were 3.7 cm and 7.3 cm lower than the mean expected values, respectively. Fracture history was recorded in 26.7% of women and 35.7% of men. BMD was negatively correlated with parathyroid hormone, FGF23, thyrotropin, and glycated hemoglobin (HbA1c) levels, and positively correlated with testosterone, IGF-1, and corticotropin levels (all P < .05). Moreover, hypothyroidism was associated with lower BMD in both the lumbar spine (P = .024) and the femoral neck (P = .004). Patients with hypothyroidism had a higher percentage of abnormal BMD (P = .016). Conclusion Hypothyroidism, higher HbA1c, and lower adrenocorticotropin were predictors of abnormal BMD in patients with β-TM. Whether the correction of these factors improves BMD warrants further research.

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