scholarly journals Spontaneous Regression of Cerebral Arteriovenous Malformation Following Onyx Embolization

Cureus ◽  
2021 ◽  
Author(s):  
Eric Feldstein ◽  
Gerald Riccardello ◽  
Krishna Amuluru ◽  
Fawaz Al-Mufti ◽  
Chirag Gandhi
Keyword(s):  
Arteriovenous Malformation ◽  
Spontaneous Regression ◽  
Cerebral Arteriovenous Malformation

Complete spontaneous regression of cerebral arteriovenous malformation: a case report and review of the literature

2018 ◽  
Vol 52 ◽  
pp. 146-151
Author(s):  
Michael E. Kritikos ◽  
Nikhil Sharma ◽  
Neda Sedora-Roman ◽  
Bryan A. Pukenas ◽  
Robert W. Hurst ◽  
...  
Keyword(s):  
Case Report ◽  
Arteriovenous Malformation ◽  
Spontaneous Regression ◽  
Cerebral Arteriovenous Malformation ◽  
Review Of The Literature

Surgery for Cerebral Arteriovenous Malformation

2015 ◽  
Vol 76 (S 02) ◽  
Author(s):  
Yoko Kato ◽  
Yasuhiro Yamada ◽  
Kei Yamashiro ◽  
Tsukasa Kawase
Keyword(s):  
Arteriovenous Malformation ◽  
Cerebral Arteriovenous Malformation

Thrombospondin-1 Modulates the Angiogenic Phenotype of Human Cerebral Arteriovenous Malformation Endothelial Cells

Neurosurgery ◽  
2011 ◽  
Vol 68 (5) ◽  
pp. 1342-1353 ◽  
Author(s):  
Christopher J. Stapleton ◽  
Don L. Armstrong ◽  
Raphael Zidovetzki ◽  
Charles Y. Liu ◽  
Steven L. Giannotta ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Arteriovenous Malformation ◽  
Immunosorbent Assay ◽  
Cerebral Arteriovenous Malformation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Boyden Chamber ◽  
Mrna Levels ◽  
Tubule Formation ◽  
Thrombospondin 1 ◽  
And Migration

Abstract BACKGROUND: The management of cerebral arteriovenous malformation (AVM) is challenging, and invasive therapies place vital intracranial structures at risk of injury. The development of noninvasive, pharmacologic approaches relies on identifying factors that mediate key angiogenic processes. Previous studies indicate that endothelial cells (ECs) derived from cerebral AVM (AVM-ECs) are distinct from control brain ECs with regard to important angiogenic characteristics. OBJECTIVE: To determine whether thrombospondin-1 (TSP-1), a potent angiostatic factor, regulates critical angiogenic features of AVM-ECs and to identify factors that modulate TSP-1 production in AVM-ECs. METHODS: EC proliferation, migration, and tubule formation were evaluated with bromodeoxyuridine incorporation, Boyden chamber, and Matrigel studies, respectively. TSP-1 and inhibitor of DNA binding/differentiation 1 (Id1) mRNA levels were quantified with microarray and quantitative real-time polymerase chain reaction analyses. TSP-1 protein expression was measured using Western blotting, immunohistochemical, and enzyme-linked immunosorbent assay techniques. The mechanistic link between Id1 and TSP-1 was established through small interfering RNA-mediated knockdown of Id1 in AVM-ECs followed by Western blot and enzyme-linked immunosorbent assay experiments assessing TSP-1 production. RESULTS: AVM-ECs proliferate faster, migrate more quickly, and form disorganized tubules compared with brain ECs. TSP-1 is significantly down-regulated in AVM-ECs. The addition of TSP-1 to AVM-EC cultures normalizes the rate of proliferation and migration and the efficiency of tubule formation, whereas brain ECs are unaffected. Id1 negatively regulates TSP-1 expression in AVM-ECs. CONCLUSION: These data highlight a novel role for TSP-1 in the pathobiology of AVM angiogenesis and provide a context for its use in the clinical management of brain AVMs.

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