scholarly journals Temporal Brain MRI Changes From Extrapontine Myelinolysis to Central Pontine Myelinolysis: A Case Report

Cureus ◽  
2021 ◽  
Author(s):  
ChengYang Lee ◽  
ChingChung Ko
2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Yahia Z. Imam ◽  
Maher Saqqur ◽  
Hassan Alhail ◽  
Dirk Deleu

Background. Extrapontine myelinolysis (EPM) has been well described in the presence of rapid correction of hyponatremia. It is seldom reported with adrenal insufficiency. We report a unique case where a patient developed EPM as a result of adrenal insufficiency where the brain MRI revealed symmetrical lesion in the basal ganglia with pallidal sparing.Case Report. A 30-year-old gentleman with panhypopituitarism developed adrenal crisis, hyponatremia, and hyponatremic encephalopathy. Seven days after the rapid correction of hyponatremia, he developed parkinsonism and neuropsychiatric symptoms. MRI showed extrapontine myelinolysis without central pontine myelinolysis.Conclusion. Extrapontine myelinolysis without central pontine myelinolysis is rare and should raise a concern of associated adrenal insufficiency in the right clinical setting. Rapid correction of hyponatremia particularly in steroid-deficient states should be avoided as it can predispose to extrapontine myelinolysis. Magnetic resonance imaging is very helpful in supporting the diagnosis of EPM.


2021 ◽  
Author(s):  
Carolina Ferreira Colaço ◽  
André Eduardo de Almeida Franzoi ◽  
Amanda Maieski ◽  
Talita Aparecida Conte ◽  
Luís Eduardo de Macedo Zubko ◽  
...  

Context: Osmotic demyelination syndrome (ODS) is rare, acute, severe and non-inflammatory. It is caused by the demyelination of neurons with the preservation of axons. It is called central pontine myelinolysis (CPM) when it affects the central pontine region and extra-pontine myelinolysis (EPM) when it affects other areas. Few cases of ODS due to non-electrolytic causes are reported. Case report: 54-year-old man with a history of heavy drinking. After about 24 hours of alcohol withdrawal, he developed generalized tonic-clonic seizures, associated with a lower level of consciousness. Protective orotracheal intubation was performed and the use of anti-crisis drugs was initiated. After sedation was switched off and mechanical ventilation was set to minimum parameters, the patient remained comatose and with convergence-retraction nystagmus movements. A skull MRI was performed, which showed lesions compatible with CPM and EPM. There was no variation in the patient’s plasma sodium during hospitalization. Conclusion: this is a patient with no evidence of any significant hydro-electrolyte disturbance and who presented a compatible neurological condition and neuroimaging characteristic of CPM / EPM. There is no specific clinical treatment for this pathology. Furthermore, the patient presents with the finding of convergence-retraction nystagmus, possibly explained by atrophy of the dorsal midbrain region.


1997 ◽  
Vol 33 (3) ◽  
pp. 572
Author(s):  
Kwon Jae Lee ◽  
Hyun Choi ◽  
Young Joon Yoon ◽  
Soo Tae Kim

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Eri Kawata ◽  
Reiko Isa ◽  
Junko Yamaguchi ◽  
Kazuna Tanba ◽  
Yasuhiko Tsutsumi ◽  
...  

2017 ◽  
Vol 41 (1) ◽  
pp. 148 ◽  
Author(s):  
Jae Ho Kim ◽  
Sae Hyun Kim ◽  
Ho Joong Jeong ◽  
Young Joo Sim ◽  
Dong Kyu Kim ◽  
...  

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