scholarly journals Association of Serotonergic Pathway Gene Polymorphisms With Behavioral Parameters in Patients With Opioid Dependence

Cureus ◽  
2021 ◽  
Author(s):  
Siddharth Sarkar ◽  
Renu Singh ◽  
Arundhati Sharma ◽  
Muzaffar A Pandit ◽  
Ranjan Gupta ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Opioid Dependence ◽  
Pathway Gene ◽  
Behavioral Parameters ◽  
Serotonergic Pathway

scholarly journals A case–control study of innate immunity pathway gene polymorphisms in Puerto Ricans reveals association of toll-like receptor 2 +596 variant with asthma

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Mario G. Ortiz-Martínez ◽  
Orquídea Frías-Belén ◽  
Sylvette Nazario-Jiménez ◽  
María López-Quintero ◽  
Rosa I. Rodríguez-Cotto ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Puerto Ricans ◽  
Case Control ◽  
Toll Like Receptor ◽  
Pathway Gene ◽  
Toll Like Receptor 2 ◽  
Innate Immunity Pathway ◽  
Control Study

Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China

2018 ◽  
Vol 34 (4) ◽  
pp. 725-729 ◽  
Author(s):  
Yulian Fang ◽  
Ruiping Zhang ◽  
Xiufang Zhi ◽  
Linsheng Zhao ◽  
Lirong Cao ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway ◽  
Gene Polymorphisms ◽  
Northern China ◽  
Han Population ◽  
Pathway Gene

scholarly journals Influence of dopaminergic system gene polymorphisms on mixed amphetamine-type stimulants and opioid dependence in Malaysian Malays

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Abu Bakar Ruzilawati ◽  
Mohd Sidek Deeza-Syafiqah ◽  
Imran Ahmad ◽  
Shaharum Shamsuddin ◽  
Siew Hua Gan ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Opioid Dependence ◽  
Dopaminergic System

scholarly journals Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chang-wang Wang ◽  
Min Ma ◽  
Wei-guang Lu ◽  
Ru-qin Luo
Keyword(s):  
Gene Polymorphisms ◽  
Opioid Dependence ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Future Studies ◽  
Larger Sample ◽  
Allelic Model ◽  
Summary Odds Ratio

Abstract Background Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility. Methods Four databases including PubMed, EMBASE, Web of Science, and Wanfang were retrieved for relevant studies before August, 2018. All identified studies were evaluated using predetermined inclusion and exclusion criteria. Summary odds ratio (OR) and 95% confidence interval (95%CI) were calculated to appraise the association. Statistical analysis was performed using RevMan 5.3 software. Results A total of seven case-control studies with 3129 cases and 3289 controls were recruited in the meta-analysis. For rs910080, rs1997794, rs1022563, and rs2235749 polymorphisms of PDYN gene, there were six, four, five, and four studies eventually included, respectively. The findings indicated that rs910080 polymorphism was significantly correlated with OD among Asian population under allelic model (A vs. G, OR = 1.30, 95% CI 1.04–1.62, P = 0.02, FDR = 0.05) and dominant model (AA+AG vs. GG, OR = 1.25, 95% CI 1.04–1.51, P = 0.02, FDR = 0.05). However, rs1022563, rs1997794 and rs2235749 polymorphisms did not appear to associate with OD susceptibility. Conclusions There existed a significant association between rs1022563 polymorphism and OD among Asian population. As the included studies were not adequate to guarantee a robust and convincing conclusion, future studies with larger sample size among more ethnicities are recommended.

Candidate Gene Polymorphisms in the Serotonergic Pathway: Influence on Depression Symptomatology in an Elderly Population

2007 ◽  
Vol 61 (2) ◽  
pp. 223-230 ◽  
Author(s):  
Lene Christiansen ◽  
Qihua Tan ◽  
Maria Iachina ◽  
Lise Bathum ◽  
Torben A. Kruse ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Gene Polymorphisms ◽  
Elderly Population ◽  
Serotonergic Pathway ◽  
Depression Symptomatology

scholarly journals Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses

2019 ◽  
Vol 5 (4) ◽  
pp. 00107-2019 ◽  
Author(s):  
Ashwini Rajasekaran ◽  
Daniel He ◽  
Alice Yue ◽  
Amrit Singh ◽  
Casey P. Shannon ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Cholinergic Synapse ◽  
Pathway Gene

scholarly journals Association between NER Pathway Gene Polymorphisms and Wilms Tumor Risk

2018 ◽  
Vol 12 ◽  
pp. 854-860 ◽  
Author(s):  
Jinhong Zhu ◽  
Wen Fu ◽  
Wei Jia ◽  
Huimin Xia ◽  
Guo-Chang Liu ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Wilms Tumor ◽  
Tumor Risk ◽  
Pathway Gene
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