scholarly journals Tumor Lysis Syndrome in Patients With Hepatocellular Carcinoma: A Systematic Review of Published Case Reports

Cureus ◽  
2021 ◽  
Author(s):  
Jen-Wei Chou ◽  
Ken-Sheng Cheng ◽  
Trupti Akella ◽  
Chi Chan Lee ◽  
Teressa Ju
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Case Reports ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis

Tumor Lysis Syndrome: A Systematic Review of Case Series and Case Reports

2012 ◽  
Vol 124 (2) ◽  
pp. 92-101 ◽  
Author(s):  
Belal M. Firwana ◽  
Rim Hasan ◽  
Nour Hasan ◽  
Fares Alahdab ◽  
Iyad Alnahhas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Tumor Lysis Syndrome ◽  
Case Series ◽  
Tumor Lysis

scholarly journals Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency

2020 ◽  
Vol 14 (2) ◽  
pp. 255-260
Author(s):  
Inna Shaforostova ◽  
Robert Fiedler ◽  
Martina Zander ◽  
Johannes Pflumm ◽  
Wolfgang Josef März
Keyword(s):  
Colon Cancer ◽  
Case Reports ◽  
Multiorgan Failure ◽  
Tumor Lysis Syndrome ◽  
Metastatic Colon Cancer ◽  
Tumor Lysis ◽  
Oncological Emergency ◽  
Electrolyte Disturbances ◽  
Life Threatening ◽  
Spontaneous Tumor Lysis Syndrome

Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here, we report a rare case of fatal STLS in a 47-year-old woman diagnosed with metastatic colon cancer. The patient developed acute renal failure with anuria, electrolyte disturbances, and metabolic acidosis before initiating chemotherapy. Despite appropriate management of TLS, including renal replacement therapy, she died within a few days from multiorgan failure. Only few other case reports of STLS associated with colon cancer have been reported in the literature.

scholarly journals Tumor Lysis Syndrome after Combination Therapy of Nivolumab and Sorafenib in a Woman with Advanced Hepatocellular Carcinoma

2020 ◽  
Vol 14 (2) ◽  
pp. 367-372 ◽  
Author(s):  
Tsai-Hung Yen ◽  
Chung-Hsin Chang ◽  
Sz-Iuan  Shiu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Combination Therapy ◽  
Tumor Lysis Syndrome ◽  
Tumor Burden ◽  
Therapeutic Interventions ◽  
Advanced Hepatocellular Carcinoma ◽  
Large Tumor ◽  
Tumor Lysis ◽  
Advanced Hcc ◽  
First Case

Tumor lysis syndrome (TLS) is a life-threatening emergency that usually develops in rapidly proliferating hematologic malignancies or advanced solid tumor following cytotoxic chemotherapy or therapeutic interventions. TLS is especially rare in patients with hepatocellular carcinoma (HCC). Therefore, we present a case of a female patient with newly diagnosed advanced HCC who developed TLS and hepatic failure after receiving combination therapy of nivolumab and sorafenib. To our knowledge, this is the first case of TLS in a patient with advanced HCC owing to combination therapy of nivolumab and sorafenib. We also reviewed the literature and summarized the characteristics of TLS in patients with advanced HCC receiving various therapeutic interventions. The overall mortality rate was 63% and regarding the management, transarterial chemoembolization (TACE) was the most common etiology. TACE-related TLS developed more rapidly than sorafenib-related TLS. Furthermore, the efficacy and safety of combination therapy of nivolumab and sorafenib should be further evaluated, and TLS should still be a concern, especially in patients with large tumor burden.

scholarly journals Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient

2015 ◽  
Vol 21 (1) ◽  
pp. 85 ◽  
Author(s):  
Jin Ok Kim ◽  
Dae Won Jun ◽  
Hye Jin Tae ◽  
Kang Nyeong Lee ◽  
Hang Lak Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Low Dose ◽  
Tumor Lysis Syndrome ◽  
Tumor Lysis ◽  
Carcinoma Patient
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