scholarly journals “Feeling the Blues”: A Case of Calcium Channel Blocker Overdose Managed With Methylene Blue

Cureus ◽  
2021 ◽  
Author(s):  
James R Pellegrini ◽  
Rezwan Munshi ◽  
Muhammad S Tiwana ◽  
Tinu Abraham ◽  
Hira Tahir ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker

scholarly journals Efficacy of Methylene Blue in an Experimental Model of Calcium Channel Blocker–Induced Shock

2015 ◽  
Vol 65 (4) ◽  
pp. 410-415 ◽  
Author(s):  
David H. Jang ◽  
Sean Donovan ◽  
Lewis S. Nelson ◽  
Theodore C. Bania ◽  
Robert S. Hoffman ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Calcium Channel ◽  
Experimental Model ◽  
Calcium Channel Blocker ◽  
Channel Blocker

scholarly journals METHYLENE BLUE LEADS TO RAPID CORRECTION OF VASOPRESSOR RESISTANT HYPOTENSION IN CALCIUM CHANNEL BLOCKER OVERDOSE

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A893-A894 ◽  
Author(s):  
Zachary Tillett ◽  
Muhammad Ibrar Islam ◽  
Mit Patel ◽  
Joshua Sill
Keyword(s):  
Methylene Blue ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Rapid Correction

scholarly journals Methylene blue reverses recalcitrant shock in  -blocker and calcium channel blocker overdose

2013 ◽  
Vol 2013 (jan18 1) ◽  
pp. bcr2012007402-bcr2012007402 ◽  
Author(s):  
N. Aggarwal ◽  
Y. Kupfer ◽  
C. Seneviratne ◽  
S. Tessler
Keyword(s):  
Methylene Blue ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker

Chronic treatment by the calcium channel blocker ± PN 200-110 in the rat counteracts the stimulations of pituitary weight, prolactin release and pituitary C-kinase activity induced by a chronic estradiol treatment, in vivo

1990 ◽  
Vol 122 (3) ◽  
pp. 403-408
Author(s):  
Ph. Touraine ◽  
P. Birman ◽  
F. Bai-Grenier ◽  
C. Dubray ◽  
F. Peillon ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Plasma Prolactin ◽  
Estradiol Treatment ◽  
Kinase C ◽  
Protein Kinase C Activity

Abstract In order to investigate whether a calcium channel blocker could modulate the protein kinase C activity in normal and estradiol pretreated rat pituitary, female Wistar rats were treated or not (controls) with ± PN 200-110 (3 mg · kg−1 · day−1, sc) for 8 days or with estradiol cervical implants for 8 or 15 days, alone or in combination with PN 200-110 the last 8 days. Estradiol treatment induced a significant increase in plasma prolactin levels and pituitary weight. PN 200-110 administered to normal rats did not modify these parameters, whereas it reduced the effects of the 15 days estradiol treatment on prolactin levels (53.1 ± 4.9 vs 95.0 ±9.1 μg/l, p<0.0001) and pituitary weight (19.9 ± 0.4 vs 23.0 ± 0.6 mg, p <0.001), to values statistically comparable to those measured after 8 days of estradiol treatment. PN 200-110 alone did not induce any change in protein kinase C activity as compared with controls. In contrast, PN 200-110 treatment significantly counteracted the large increase in soluble activity and the decrease in the particulate one induced by estradiol between day 8 and day 15. We conclude that PN 200-110 opposed the stimulatory effects of chronic in vivo estradiol treatment on plasma prolactin levels and pituitary weight and that this regulation was related to a concomitant modulation of the protein kinase C activity.

Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-Acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-Analysis of the COPE Trial

2020 ◽  
Vol 16 ◽  
Author(s):  
Seiji Umemoto ◽  
Toshio Ogihara ◽  
Masunori Matsuzaki ◽  
Hiromi Rakugi ◽  
Kazuyuki Shimada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Rank Test ◽  
Vascular Events ◽  
Treatment Groups ◽  
Β Blocker ◽  
The Difference ◽  
Long Acting

Background: In the trial known as COPE (Combination Therapy of Hypertension to Prevent Cardiovascular Events) three benidipine (a calcium channel blocker; CCB) regimens were compared. Hypertensive Japanese outpatients aged 40–85 years (n=3,293) who did not achieve the target blood pressure of <140/90 mmHg with benidipine 4 mg/day were treated with the diuretic thiazide (n=1,094) or a β-blocker (n=1,089) or an additional angiotensin receptor blocker (ARB; n=1,110). A significantly higher incidence of hard cardiovascular composite endpoints and of fatal or non-fatal strokes was observed in the benidipine-β-blocker group compared to the benidipine-thiazide group. Objective and Methods: We further evaluated the treatment effects of the three benidipine-based regimens on vascular and renal events in a sub-analysis of the COPE patients. Results: A total of 10 vascular events (0.8 per 1,000 person-years) including one aortic dissection (0.1 per 1,000 person-years) and nine cases of peripheral artery disease (0.8 per 1,000 person-years) were documented, as was a total of seven renal events (0.6 per 1,000 person-years). No significant differences in vascular and renal events were revealed among the three treatment groups: vascular events p=0.92 renal events p=0.16 log-rank test. Conclusions: Blood pressure-lowering therapy with benidipine combined with an ARB, β-blocker, or thiazide was similarly effective in the prevention of vascular and renal events in hypertensive outpatients, although there is no enough these events to compare the difference in the three treatment groups.

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