scholarly journals Transient Bilateral Ophthalmoplegia: A Case of a Forgotten Anesthetic Medication Effect

Cureus ◽  
2021 ◽  
Author(s):  
Sara J Hyland ◽  
Tapan R Kavi ◽  
Nicole R Smith ◽  
Jacky Lin ◽  
Mark D Catton
Keyword(s):  
Medication Effect

Measurement of Pain and Medication Effect in a Study of Duloxetine

2008 ◽  
Vol 69 (6) ◽  
pp. 1022
Author(s):  
Jay M. Griffith ◽  
Joseph P. Hasley ◽  
Daniel G. Severn
Keyword(s):  
Medication Effect

scholarly journals PH Professional Network: Drug-Drug Interactions: Treatment Considerations for Pulmonary Hypertension Patients With Human Immunodeficiency Virus and/or Hepatitis C

2018 ◽  
Vol 17 (2) ◽  
pp. 75-79
Author(s):  
Traci Housten ◽  
Laura Duvall ◽  
Pavithra Srinivas
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C ◽  
Drug Interactions ◽  
Disease States ◽  
Medication Effect ◽  
Professional Network ◽  
Immunodeficiency Virus ◽  
Treatment Considerations ◽  
Pulmonary Arterial ◽  
Treatment Medication

Managing pulmonary arterial hypertension (PAH) treatment is a complex balance of achieving the desired medication effect versus maintaining safe and tolerable side effects for the patient. The “balancing act” intensifies when PAH patients are faced with multiple disease states that require treatment medication. This article will focus on the drug-drug interactions that must be considered in PAH patients with concomitant human immunodeficiency virus (HIV) and/or hepatitis C virus (HCV) infection.

scholarly journals Dream Activity in Narcoleptic Patients During the COVID-19 Lockdown in Italy

2021 ◽  
Vol 12 ◽  
Author(s):  
Serena Scarpelli ◽  
Valentina Alfonsi ◽  
Anita D'Anselmo ◽  
Maurizio Gorgoni ◽  
Alessandro Musetti ◽  
...  
Keyword(s):  
Sleep Disturbances ◽  
Small Sample Size ◽  
Female Gender ◽  
Small Sample ◽  
Dream Recall ◽  
Cross Sectional ◽  
Future Studies ◽  
Medication Effect ◽  
Cross Sectional Design

Some studies highlighted that patients with narcolepsy type-1 (NT1) experience high lucid dream frequency, and this phenomenon has been associated with a creative personality. Starting from the well-known “pandemic effect” on sleep and dreaming, we presented a picture of dream activity in pharmacologically treated NT1 patients during the Italian lockdown. Forty-three NT1 patients completed a web-survey during Spring 2021 and were compared with 86 matched-controls. Statistical comparisons revealed that: (a) NT1 patients showed greater sleepiness than controls; (b) controls showed higher sleep disturbances than NT1 patients, and this result disappeared when the medication effect in NT1 was controlled; (c) NT1 patients reported higher lucid dream frequency than controls. Focusing on dreaming in NT1 patients, we found that (a) nightmare frequency was correlated with female gender, longer sleep duration, higher intrasleep wakefulness; (b) dream recall, nightmare and lucid dream frequency were positively correlated with sleepiness. Comparisons between low and high NT1 lucid dreamers showed that patients more frequently experiencing lucid dreams reported a greater influence of dreaming during wakefulness, especially concerning problem-solving and creativity. Overall, our results are consistent with previous studies on pandemic dreaming carried out on healthy subjects. Moreover, we confirmed a link between lucidity and creativity in NT1 patients. Considering the small sample size and the cross-sectional design, our findings cannot provide a causal relationship between lucid dreams and the COVID-19 lockdown. Nevertheless, they represent a first contribution to address future studies on this issue, suggesting that some stable characteristics could interact with changes provoked by the pandemic.

Differential Response to Methylphenidate in Inattentive and Combined Subtype ADHD

2016 ◽  
Vol 21 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Susan H. Beery ◽  
Herbert C. Quay ◽  
William E. Pelham
Keyword(s):  
Problem Behaviors ◽  
Treatment Program ◽  
Verbal Abuse ◽  
Effect Sizes ◽  
Double Blind ◽  
Children With Adhd ◽  
Double Blind Placebo ◽  
Summer Treatment Program ◽  
Medication Effect ◽  
Work Completion

Objective: To examine response to methylphenidate (MPH) assessed by direct observation of ecologically valid behaviors in boys with ADHD with high hyperactivity-impulsivity (HI) and those with predominantly inattentive symptoms (ADHD/I). Method: Sixty-three boys ages 7 to 13 participated in an ADHD Summer Treatment Program and received a double-blind placebo-controlled assessment of .3 mg/kg of MPH on problem behaviors and individualized behavior goals. Medication effect sizes were calculated for each child for each behavior. Results: Children with ADHD/HI ( n = 21) displayed larger MPH effect sizes for interrupting, verbal abuse, and compliance, and marginally greater response for teasing and counselor-directed goals. Children with ADHD/I ( n = 21) displayed small medication effect sizes ( ds < .20) for many behaviors often identified as primary deficits in this group (e.g., attention to activities, peer interaction, class work completion, and accuracy). Conclusion: Systematic medication assessment for ADHD/I that quantifies response in ecologically valid areas of functional impairment is essential.

823 Apparent seizure activity in a 9 year old female presenting as hypnopompic hallucinations

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A321-A321
Author(s):  
Jason Rakita ◽  
Brooke Judd
Keyword(s):  
Nocturnal Enuresis ◽  
Seizure Activity ◽  
Nrem Sleep ◽  
Medical Disorder ◽  
Medication Effect ◽  
Mallampati Score ◽  
Obstructive Sleep ◽  
Mild Obstructive Sleep Apnea ◽  
History Of ◽  
One Year

Abstract Introduction The presence of hypnopompic hallucinations raises concerns for narcolepsy. However, sleep-related hallucinations may occur in other settings. Dreams at sleep-wake transitions may be difficult for patients to differentiate from sleep-related hallucinations. Sleep-related hallucinations are predominantly visual, although they can be auditory, tactile and/or kinetic. However, they are generally not olfactory in nature. Report of case(s) Here we present a case of a 9-year-old female with a history of tonsillectomy and adenoidectomy, ADHD, ODD, nocturnal enuresis, nocturia, aggressive behaviors and emotional outbursts who presented with EDS, frequent nocturnal awakenings, involuntary dozing, prolonged naps and a one year duration of hypnopompic hallucinations. Initially, the hallucinations occurred 2–3 times per week, but then decreased in frequency to 2–3 times per month. The frequency of episodes apparently decreased after tonsillectomy. She states that she wakes up and sees dots, and “she looks scary” when she looks at herself. She describes a variety of hallucinations including: seeing dots (including her mother being covered in dots), a cupcake, a strange woman walking, her hands looking strange--they had enlarged or hearing noises (a single loud bang). Pertinent physical exam findings included: BMI 66th percentile, Mallampati score 2/4, and a mildly enlarged tongue. The polysomnogram demonstrated mild obstructive sleep apnea by pediatric criteria, and, most notably, demonstrated an EEG with spike and wave formations in the central and frontal leads bilaterally. These were seen during NREM sleep and most prominently during sleep-wake transitions. There was also a more focal brief run of a regular 2 Hz rhythm in the central and frontal leads bilaterally. A referral was placed to Pediatric Neurology who ordered a full EEG which is pending at this time. Conclusion Sleep-related hallucinations may occur in narcolepsy, other sleep disorders, a mental disorder, a medical disorder, a medication effect or secondary to substance use. This case suggests that seizure activity may present as hypnopompic hallucinations as well. Support (if any):

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