scholarly journals Evaluation of In Vivo Adhesion Properties of New Generation Polyglactin, Oxidized Regenerated Cellulose and Chitosan-Based Meshes for Hernia Surgery

Cureus ◽  
2021 ◽  
Author(s):  
Mehmet Gulmez ◽  
Ali Aktekin ◽  
Fugen Aker ◽  
Vildan Sanko ◽  
Serdar Sezer
Keyword(s):  
Regenerated Cellulose ◽  
Oxidized Regenerated Cellulose ◽  
Hernia Surgery ◽  
Adhesion Properties ◽  
New Generation

Hemostatic wound dressings: Predicting their effects by in vitro tests

2019 ◽  
Vol 33 (9) ◽  
pp. 1285-1297 ◽  
Author(s):  
Cornelia Wiegand ◽  
Martin Abel ◽  
Uta-Christina Hipler ◽  
Peter Elsner ◽  
Michael Zieger ◽  
...  
Keyword(s):  
Blood Clot ◽  
Wound Dressings ◽  
In Vitro Tests ◽  
Regenerated Cellulose ◽  
Oxidized Regenerated Cellulose ◽  
Inflammatory Reactions ◽  
In Vitro Techniques ◽  
Cotton Gauze

Background Application of controlled in vitro techniques can be used as a screening tool for the development of new hemostatic agents allowing quantitative assessment of overall hemostatic potential. Materials and methods Several tests were selected to evaluate the efficacy of cotton gauze, collagen, and oxidized regenerated cellulose for enhancing blood clotting, coagulation, and platelet activation. Results Visual inspection of dressings after blood contact proved the formation of blood clots. Scanning electron microscopy demonstrated the adsorption of blood cells and plasma proteins. Significantly enhanced blood clot formation was observed for collagen together with β-thromboglobulin increase and platelet count reduction. Oxidized regenerated cellulose demonstrated slower clotting rates not yielding any thrombin generation; yet, led to significantly increased thrombin-anti-thrombin-III complex levels compared to the other dressings. As hemostyptica ought to function without triggering any adverse events, induction of hemolysis, instigation of inflammatory reactions, and initiation of the innate complement system were also tested. Here, cotton gauze provoked high PMN elastase and elevated SC5b-9 concentrations. Conclusions A range of tests for desired and undesired effects of materials need to be combined to gain some degree of predictability of the in vivo situation. Collagen-based dressings demonstrated the highest hemostyptic properties with lowest adverse reactions whereas gauze did not induce high coagulation activation but rather activated leukocytes and complement.

In vivo degradation of oxidized, regenerated cellulose

1990 ◽  
Vol 198 (2) ◽  
pp. 331-341 ◽  
Author(s):  
S. Dan Dimitrijevich ◽  
Matthew Tatarko ◽  
Robert W. Gracy ◽  
Gary E. Wise ◽  
Lawrence X. Oakford ◽  
...  
Keyword(s):  
Regenerated Cellulose ◽  
Oxidized Regenerated Cellulose ◽  
In Vivo Degradation

Flavonoids as P-gp Inhibitors: A Systematic Review of SARs

2019 ◽  
Vol 26 (25) ◽  
pp. 4799-4831 ◽  
Author(s):  
Jiahua Cui ◽  
Xiaoyang Liu ◽  
Larry M.C. Chow
Keyword(s):  
Molecular Mechanisms ◽  
Metastatic Cancer ◽  
Drug Candidates ◽  
Chemical Structures ◽  
Transporter Family ◽  
Promising Area ◽  
New Generation ◽  
Nontoxic Inhibitors

P-glycoprotein, also known as ABCB1 in the ABC transporter family, confers the simultaneous resistance of metastatic cancer cells towards various anticancer drugs with different targets and diverse chemical structures. The exploration of safe and specific inhibitors of this pump has always been the pursuit of scientists for the past four decades. Naturally occurring flavonoids as benzopyrone derivatives were recognized as a class of nontoxic inhibitors of P-gp. The recent advent of synthetic flavonoid dimer FD18, as a potent P-gp modulator in reversing multidrug resistance both in vitro and in vivo, specifically targeted the pseudodimeric structure of the drug transporter and represented a new generation of inhibitors with high transporter binding affinity and low toxicity. This review concerned the recent updates on the structure-activity relationships of flavonoids as P-gp inhibitors, the molecular mechanisms of their action and their ability to overcome P-gp-mediated MDR in preclinical studies. It had crucial implications on the discovery of new drug candidates that modulated the efflux of ABC transporters and also provided some clues for the future development in this promising area.

Treatment of a Bronchopleural Fistula With a Fogarty Catheter and Oxidized Regenerated Cellulose (Surgicel)

CHEST Journal ◽  
1994 ◽  
Vol 105 (6) ◽  
pp. 1879-1881 ◽  
Author(s):  
Juraj Sprung ◽  
Mark J. Krasna ◽  
Amy Yun ◽  
Padmini Thomas ◽  
Denis L. Bourke
Keyword(s):  
Bronchopleural Fistula ◽  
Regenerated Cellulose ◽  
Fogarty Catheter ◽  
Oxidized Regenerated Cellulose

scholarly journals In vivo soft tissue reinforcement with bacterial nanocellulose

2021 ◽  
Author(s):  
Irene Anton-Sales ◽  
Soledad Roig-Sanchez ◽  
Kamelia Anna Traeger ◽  
Christine Weis ◽  
Anna Laromaine ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Hernia Surgery ◽  
Bacterial Nanocellulose ◽  
Surgical Meshes

The use of surgical meshes to reinforce damaged internal soft tissues has been instrumental for successful hernia surgery; a highly prevalent condition affecting yearly more than 20 million patients worldwide....

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