scholarly journals Neuromodulation in Intractable Epilepsy Through Responsive Vagal Nerve Stimulation: A Three-Year Retrospective Study at the University of Texas Medical Branch, Galveston

Cureus ◽  
2021 ◽  
Author(s):  
Joseph Villarreal ◽  
Vijaya Lakshmi Valaparla ◽  
Kyra Curtis ◽  
Neeharika Thottempudi ◽  
Sama Elrahi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Nerve Stimulation ◽  
Intractable Epilepsy ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Texas Medical ◽  
University Of Texas ◽  
The University

scholarly journals A Novel Statistical Model for Predicting the Efficacy of Vagal Nerve Stimulation in Patients With Epilepsy (Pre-X-Stim) Is Applicable to Different EEG Systems

2021 ◽  
Vol 15 ◽  
Author(s):  
Eva Korit́áková ◽  
Irena Doležalová ◽  
Jan Chládek ◽  
Tereza Jurková ◽  
Jan Chrastina ◽  
...  
Keyword(s):  
Statistical Model ◽  
Nerve Stimulation ◽  
Real World ◽  
Real Life ◽  
Intractable Epilepsy ◽  
Power Spectra ◽  
Recording System ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Validation Experiments

Background: Identifying patients with intractable epilepsy who would benefit from therapeutic chronic vagal nerve stimulation (VNS) preoperatively remains a major clinical challenge. We have developed a statistical model for predicting VNS efficacy using only routine preimplantation electroencephalogram (EEG) recorded with the TruScan EEG device (Brazdil et al., 2019). It remains to be seen, however, if this model can be applied in different clinical settings.Objective: To validate our model using EEG data acquired with a different recording system.Methods: We identified a validation cohort of eight patients implanted with VNS, whose preimplantation EEG was recorded on the BrainScope device and who underwent the EEG recording according to the protocol. The classifier developed in our earlier work, named Pre-X-Stim, was then employed to classify these patients as predicted responders or non-responders based on the dynamics in EEG power spectra. Predicted and real-world outcomes were compared to establish the applicability of this classifier. In total, two validation experiments were performed using two different validation approaches (single classifier or classifier voting).Results: The classifier achieved 75% accuracy, 67% sensitivity, and 100% specificity. Only two patients, both real-life responders, were classified incorrectly in both validation experiments.Conclusion: We have validated the Pre-X-Stim model on EEGs from a different recording system, which indicates its application under different technical conditions. Our approach, based on preoperative EEG, is easily applied and financially undemanding and presents great potential for real-world clinical use.

Closed-loop vagal nerve stimulation for intractable epilepsy: A single-center experience

Seizure ◽  
2021 ◽  
Vol 88 ◽  
pp. 95-101
Author(s):  
Graham M. Winston ◽  
Sergio Guadix ◽  
Miguel Tusa Lavieri ◽  
Rafael Uribe-Cardenas ◽  
Gary Kocharian ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Closed Loop ◽  
Intractable Epilepsy ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Single Center ◽  
Single Center Experience

Vagal nerve stimulation in children under 12 years old with medically intractable epilepsy

2013 ◽  
Vol 29 (11) ◽  
pp. 2095-2099 ◽  
Author(s):  
S Healy ◽  
J Lang ◽  
J Te Water Naude ◽  
F Gibbon ◽  
P Leach
Keyword(s):  
Nerve Stimulation ◽  
Intractable Epilepsy ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation
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