scholarly journals An Interesting Case of Immunoglobulin G4-Related Retroperitoneal Fibrosis Treated With Rituximab

Cureus ◽  
2021 ◽  
Author(s):  
Ahmad Hamdan ◽  
Zunera Moeen ◽  
Hina Tariq ◽  
Olga Olson ◽  
Carlos Matute-Martinez ◽  
...  
Keyword(s):  
Retroperitoneal Fibrosis ◽  
Interesting Case ◽  
Immunoglobulin G4

Retroperitoneal fibrosis showing immunoglobulin G4-positive monoclonal B-lymphocytes

2011 ◽  
Vol 52 (11) ◽  
pp. 2179-2181 ◽  
Author(s):  
Masaru Kojima ◽  
Tadashi Motoori ◽  
Masahumi Nishikawa ◽  
Hazuki Matsuda ◽  
Nobuhide Masawa ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Retroperitoneal Fibrosis ◽  
Immunoglobulin G4

scholarly journals Immunoglobulin G4 related disease: an overview

2021 ◽  
Vol 15 (2) ◽  
pp. 44-51
Author(s):  
Saika Farook ◽  
Abdullah Ahmed Solaiman ◽  
Md Shariful Alam Jilani
Keyword(s):  
Retroperitoneal Fibrosis ◽  
Tubulointerstitial Nephritis ◽  
The Body ◽  
Histopathological Analysis ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Serum Igg4 ◽  
First Time ◽  
Gland Enlargement

Immunoglobulin G4 related disease (IgG4-RD) is a recently perceived fibroinflammatory condition, identified as a systemic illness for the first time in the early 2000. It can involve virtually every organ of the body, commonly presenting as lymphadenopathy, retroperitoneal fibrosis, autoimmune pancreatitis, tubulointerstitial nephritis, parotid or lacrimal gland enlargement. The diagnosis is confirmed by histopathological analysis and is often, but not always accompanied by an increased level of serum IgG4 concentration. In fact, the name addressing this autoimmune fibroinflammatory condition may be considered a misnomer, as the role of the non-inflammatory immunoglobulin IgG4 in the immune mechanism of IgG4-RD remains to be elucidated. Ibrahim Med. Coll. J. 2021; 15(2): 44-51

Retroperitoneal Fibrosis: A Clinicopathologic Study With Respect to Immunoglobulin G4

2009 ◽  
Vol 33 (12) ◽  
pp. 1833-1839 ◽  
Author(s):  
Yoh Zen ◽  
Manabu Onodera ◽  
Dai Inoue ◽  
Azusa Kitao ◽  
Osamu Matsui ◽  
...  
Keyword(s):  
Retroperitoneal Fibrosis ◽  
Immunoglobulin G4 ◽  
Clinicopathologic Study

scholarly journals A Case of Immunoglobulin G4-Related Disease with Extensive Multiorgan Involvements

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Kazuhiko Higashioka ◽  
Kenji Yoshida ◽  
Kensuke Oryoji ◽  
Kazuo Kamada ◽  
Shinichi Mizuki ◽  
...  
Keyword(s):  
Retroperitoneal Fibrosis ◽  
Elevated Serum ◽  
Clinical Findings ◽  
Organ Involvement ◽  
Immunoglobulin G4 ◽  
Serum Igg4 Level ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Serum Igg4 ◽  
Igg4 Level

We report a case of IgG4-related disease (IgG4-RD) with multiple ten-organ involvement. This case showed many clinical findings, such as bilateral swelling of salivary and lacrimal glands, autoimmune pancreatitis, interstitial nephritis, retroperitoneal fibrosis, periaortitis, systemic swelling of lymph nodes, pulmonary lesions, splenomegaly, and jejunal lesions. He was suspected as having SLE or malignant lymphoma but diagnosed as having IgG4-RD by the elevated serum IgG4 level and histological findings from kidney and lymph node. We report a case of IgG4-RD with multiple ten-organ involvement that was successfully treated with prednisolone therapy.

Idiopathic retroperitoneal fibrosis: an update for nephrologists

2020 ◽  
Author(s):  
Valentina Raglianti ◽  
Giovanni M Rossi ◽  
Augusto Vaglio
Keyword(s):  
Retroperitoneal Fibrosis ◽  
Obstructive Uropathy ◽  
Human Leukocyte ◽  
Rare Condition ◽  
Biologic Drugs ◽  
Idiopathic Retroperitoneal Fibrosis ◽  
Immunoglobulin G4 ◽  
Increased Risk ◽  
Environmental Agents ◽  
Stage Renal Disease

Abstract Idiopathic retroperitoneal fibrosis (IRF) is a rare condition characterized by the development of a peri-aortic and peri-iliac tissue showing chronic inflammatory infiltrates and pronounced fibrosis. Ureteral entrapment with consequent obstructive uropathy is one of the most common complications of IRF, which can lead to acute renal failure and, in the long term, to varying degrees of chronic kidney disease. IRF may be isolated or develop in association with autoimmune diseases (e.g. Hashimoto’s thyroiditis and psoriasis) and other fibro-inflammatory disorders (often within the spectrum of immunoglobulin G4-related disease), which suggests that it should be considered as a potentially systemic condition. IRF is an immune-mediated disease: genetic variants (e.g. human leukocyte antigen (HLA)-DRB1*03) and environmental agents (mainly exposure to asbestos and smoking) are strongly associated with an increased risk of developing the disease, while a complex network of chemokines (e.g. CXCL12 and C-C moti chemokine 11 (CCL11)) and cytokines [e.g. interleukin (IL)-6, IL-12 and IL-13] is likely to orchestrate the inflammatory response and simultaneously promote fibrosis. Glucocorticoids, alone or in combination with traditional immunosuppressants such as methotrexate and mycophenolate mofetil, are usually efficacious and promptly induce disease remission; however, up to 50% of patients relapse, thus requiring repeat immunosuppressive courses. Biologic drugs, namely rituximab, are being explored for the treatment of IRF. In addition to medical therapies, interventional procedures (mainly ureteral stenting) are required to relieve ureteral obstruction, whereas surgical ureterolysis is generally reserved to refractory cases. If appropriately treated, then the overall and renal prognosis of IRF are good, with <5% patients developing end-stage renal disease.

scholarly journals Delayed Radiographic Presentation of IgG4 Vasculitis

2019 ◽  
pp. 1-2
Author(s):  
Naureen Osman ◽  
Julie Schwartzman-Morris
Keyword(s):  
Inflammatory Process ◽  
Interesting Case ◽  
Large Vessel Vasculitis ◽  
Large Vessel ◽  
Radiographic Imaging ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Multiple Organs ◽  
Igg4 Related Disease ◽  
Radiographic Presentation

Immunoglobulin G4 (IgG4) related disease is a systemic inflammatory process that affects multiple organs and can commonly present with large vessel vasculitis. We present an interesting case of a patient with delayed manifestation of IgG4 related vasculitis on radiographic imaging.

scholarly journals Retroperitoneal fibrosis in the era of immunoglobulin G4-related disease

2019 ◽  
Vol 38 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Yoon Kyung Choi ◽  
Ji Hyun Yang ◽  
Shin Young Ahn ◽  
Gang Jee Ko ◽  
Se Won Oh ◽  
...  
Keyword(s):  
Retroperitoneal Fibrosis ◽  
Immunoglobulin G4 ◽  
Related Disease
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