scholarly journals High Serum Uric Acid and High-Sensitivity C Reactive Protein Concentrations Predict Three-Year Cardiovascular Mortality in Patients Treated With Continuous Ambulatory Peritoneal Dialysis

Cureus ◽  
2021 ◽  
Author(s):  
Quyen Dao Bui Quy ◽  
Tuan Pham Ngoc Huy ◽  
Tuan Nguyen Minh ◽  
Loc Nguyen Duc ◽  
Tuan Nguyen Minh ◽  
...  
Keyword(s):  
Uric Acid ◽  
Peritoneal Dialysis ◽  
Serum Uric Acid ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Cardiovascular Mortality ◽  
High Sensitivity ◽  
High Serum ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Study of Correlation between High Sensitivity C-Reactive Protein and Serum Uric Acid in Acute Stroke

2021 ◽  
Vol 10 (15) ◽  
pp. 1074-1078
Author(s):  
Jayachandra Jayachandra ◽  
Arjun P. Chandrashekar ◽  
Sowrabha S. Bhat ◽  
Yoganand Yoganand ◽  
Chethan Chethan ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Acute Stroke ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
Risk Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Clinical Records

BACKGROUND Relationship between serum uric acid and cardiovascular system has been recognised since years. High-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular and cerebrovascular events. The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it.1 It is unclear as to whether high uric acid concentrations promote or protect against the development of cerebrovascular disease, or simply acts as a passive marker of increased risk. As serum hs-CRP is an established risk factor for stroke, its positive correlation with serum uric acid levels would suggest that high serum uric acid could predict stroke risk. Also, it would prove to be a more cost-effective investigative tool in our present set up. METHODS In this cross-sectional study, we assessed 100 patients admitted with acute stroke in Victoria and Bowring and Lady Curzon Hospital from October 2016 to November 2018. Clinical records, routine investigations, radiological imaging, serum uric acid and hs-CRP of the patients were investigated. RESULTS Majority of the patients (33 %) belonged to the age group of > 70 yrs., followed by 61 - 70 yrs. (26 %). 69 % of the patients were males and 31 % were females. 67 % of them were hypertensive and 32 % were diabetic. 91 % had an hs-CRP level of > 3.0 mg / L and 8 % had hs-CRP levels between 1.0 and 3.0 mg / L. None of the female patients had a serum uric acid value > 6.5 mg / dL and none of the male patients had a uric acid level of > 7.0 mg / dL. There was a correlation between serum uric acid levels and serum hs-CRP levels in patients ≤ 50 yrs. of age. There was no correlation between serum hs-CRP levels and serum uric acid levels in patients more than 50 yrs. of age. CONCLUSIONS Our study showed that stroke is most common in persons > 70 yrs. of age and is more common in males compared to females. Hypertension is an independent risk factor for stroke. hs-CRP is a well-established risk marker for stroke, being raised in majority of stroke patients. Serum uric acid is not raised in all patients of acute stroke. So, it cannot be used as a risk marker for stroke. KEY WORDS hs-CRP, Serum Uric Acid, Acute Stroke

scholarly journals HUBUNGAN KADAR ASAM URAT SERUM DENGAN KADAR HIGH-SENSITIVITY C-REACTIVE PROTEIN PADA REMAJA OBES

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Agustinus Mahardhika Sarayar
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Obese Subject ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Reactive Protein ◽  
Hs Crp ◽  
Spearman Test

Abstract: Uric acid has low water solubility. When the concentration exceeds its solubility, it will form monosodium urate (MSU) crystals which can trigger inflammation. High sensitivity C-reactive protein (hs-CRP) is one of the most liable inflammatory biomarker and recently considered as major modifiable risk factor of coronary heart disease. Serum uric acid and hs-CRP levels are often elevated in obese patients. The purpose of this study are to determine hs-CRP and serum uric acid levels and to determine the correlation between serum uric acid and hs-CRP  levels in obese adolescents. This is an analytic observational study with cross sectional design. Subject consist of 17 obese adolescents age 17-20 years with percentile of ≥ 95 in CDC BMI-for-age chart. Nonparametric analysis with Spearman test was applied to find the correlation between serum uric acid and hs-CRP levels. The mean serum uric acid and hs-CRP levels in obese subjects were 7.37 (SD 1.66) mg/dL and  1.73 (SD 1.44) mg/L respectively. In conclusion, a statistically insignificant correlation between serum uric acid and hs-CRP levels was found (p = 0.296, r = 0.14). Serum uric acid levels  are consistently higher in obese adolescents. Hs-CRP levels among obese subject shows moderate risk of developing cardiovascular disease in the future. Keywords: Adolescents, hs-CRP, obese, serum uric acid    Abstrak: Asam urat memiliki kelarutan yang rendah dalam air. Saat konsentrasi asam urat melebihi batas ambang solubilitas, akan terbentuk kristal monosodium urat yang akan memicu inflamasi. High sensitivity C-reactive protein (hs-CRP) merupakan salah satu biomarker inflamasi yang belakangan ini dijadikan faktor risiko mayor yang dapat dimodifikasi dari penyakit jantung koroner. Kadar asam urat serum dan hs-CRP biasanya meningkat pada penderita obesitas. Tujuan dari penelitian ini untuk mengetahui hubungan kadar asam urat serum dengan hs-CRP serta gambaran kadar asam urat serum dan hs-CRP pada remaja obes. Penelitian ini menggunakan desain penelitian analitik observasional  dengan pendekatan cross-sectional. Subjek terdiri dari 17 remaja obes usia 17-20 tahun dengan persentil ≥ 95 pada grafik IMT terhadap usia CDC. Analisis data menggunakan Spearman test digunakan untuk mengetahui korelasi antara kadar asam urat serum dengan hs-CRP. Nilai rata-rata kadar asam urat serum dan hs-CRP yang didapat secara berurutan mencapai 7,37 (SD 1,66) mg/dL dan 1,73 (SD 1,44) mg/L. Sebagai kesimpulan, hubungan kadar asam urat serum dengan hs-CRP tidak signifikan (p = 0,296) dan berkorelasi positif lemah (r = 0,14). Kadar asam urat serum pada remaja obes tergolong tinggi. Kadar hs-CRP remaja obes termasuk dalam risiko menengah untuk terkena penyakit kardiovaskular di masa mendatang. Kata kunci: Asam urat serum, hs-CRP, Obesitas, Remaja

scholarly journals Association of serum uric acid with high-sensitivity C-reactive protein in postmenopausal women

Climacteric ◽  
2016 ◽  
Vol 20 (1) ◽  
pp. 44-48 ◽  
Author(s):  
A. Raeisi ◽  
A. Ostovar ◽  
K. Vahdat ◽  
P. Rezaei ◽  
H. Darabi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Postmenopausal Women ◽  
Serum Uric Acid ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

Association between serum uric acid, high sensitive C-reactive protein and pro-oxidant-antioxidant balance in patients with metabolic syndrome

BioFactors ◽  
2018 ◽  
Vol 44 (3) ◽  
pp. 263-271 ◽  
Author(s):  
Mahsa Ahmadnezhad ◽  
Seyed Rafie Arefhosseini ◽  
Mohammad Reza Parizadeh ◽  
Shima Tavallaie ◽  
Maryam Tayefi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
C Reactive Protein ◽  
Reactive Protein

Hyperuricaemia in congenital heart disease patients

2013 ◽  
Vol 25 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Efrén Martínez-Quintana ◽  
Fayna Rodríguez-González
Keyword(s):  
Body Mass Index ◽  
Congenital Heart Disease ◽  
Uric Acid ◽  
Heart Disease ◽  
Serum Uric Acid ◽  
Congenital Heart ◽  
C Reactive Protein ◽  
Lower Serum ◽  
Reactive Protein ◽  
Low Serum

AbstractIntroductioHyperuricaemia is associated with traditional cardiovascular risk factors such as type 2 diabetes or dyslipidaemia and a higher mortality.MethodsOut of 528 congenital heart disease patients, 329 patients, including 190 male and 139 female patients, in whom uric acid determination was performed, were studied and followed up to determine survival.ResultsMale congenital heart disease patients with high serum uric acid concentrations (>7 mg/dl) showed significantly (p < 0.05) higher body mass index, serum creatinine, total cholesterol, low-density lipoprotein-cholesterol, triglycerides, and C-reactive protein concentrations than those male congenital heart disease patients with lower serum uric acid levels (≤7 mg/dl). Meanwhile, female congenital heart disease patients with higher serum uric acid concentrations (>5.7 mg/dl) were significantly (p < 0.05) younger, more hypoxaemic, more obese, and with higher C-reactive protein and N-terminal-pro-B-type natriuretic peptide levels than those female congenital heart disease patients with lower serum uric acid concentrations (≤5.7 mg/dl). During a median follow-up of 90 months, 16 out of 528 congenital heart disease patients died – 14 patients of cardiac origin and two patients of non-cardiac origin – of whom 10 were hypoxaemic. Kaplan–Meier analysis showed no significant differences in mortality between male and female congenital heart disease patients with high and low serum uric acid level concentrations.ConclusionsHypoxaemia, body mass index, and C-reactive protein concentrations are higher in hyperuricaemic congenital heart disease patients, although no significant differences were seen in mortality between congenital heart disease patients with high and low serum uric acid concentrations.

Sign in / Sign up

Export Citation Format

Share Document